Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

Remibrutinib treatment of chronic spontaneous urticaria (CSU) leads to fast, early symptom control versus placebo, according to new post-hoc analysis data presented at the 

2026 American Academy of Dermatology (AAD) Annual Meeting

CSU is a chronic, idiopathic condition characterized by the recurrence of hives, pruritus, angioedema, or a combination of such symptoms lasting longer than 6 weeks.

 The condition is known to disproportionately impact women, and this is especially the case among those between 20 - 40 years of age. CSU is linked with a substantial burden, as beyond its physical manifestations, the disease has significant psychological and economic implications. The annual healthcare-related costs of CSU in the US exceed $200 million.

Remibrutinib is an oral, highly selective Bruton's tyrosine kinase (BTK) inhibitor, and had previously demonstrated efficacy and a positive safety profile in previous phase 2b data.

 During the latest phase 3 REMIX-1 and REMIX-2 trials, which are identical, multicenter, randomized, double-blind, placebo-controlled studies, remibrutinib was administered as an add-on therapy for patients whose symptoms persisted despite second-generation H1-antihistamines.

In these new data, the drug showed superior efficacy compared with placebo at the 12-week mark. The therapy has since been approved in both the US and China. In the current post-hoc analysis pooled data from the REMIX-1 and REMIX-2 trials, presented during AAD 2026, the investigative team set out to better understand how quickly patients begin to experience CSU symptom improvement after beginning remibrutinib treatment.

The team focused on daily hive severity scores (HSS) and itch severity scores (ISS), seeking to assess both mean shifts in scores over time and the proportion of individuals in the studies attaining complete resolution of their CSU symptoms (defined as HSS = 0 for no hives and ISS = 0 for no itch) from baseline through the first 7 days of therapy use.

They calculated both HSS and ISS via averaged morning and evening assessments, with the exception of the first day. This was when only the post-dose evening measurement, taken 12 hours after dosing, was included due to pre-dose morning values. Scoring of CSU severity ranged from 0 - 3, with higher scores suggesting a greater level of symptom burden.

Overall, the investigators’ pooled post-hoc data showed remibrutinib implementation led to a rapid reduction in CSU disease activity, with the investigators noting measurable improvements in both itch and hive severity within the first 12 hours following the initial remibrutinib dose. This early onset of action was notably faster than what was observed in the placebo arm. Additionally, the team found a higher proportion of those on remibrutinib attained complete resolution of symptoms within this same 12-hour timeframe.

The benefits persisted over the initial week of treatment. Across days 1 - 7, participants treated with remibrutinib consistently showed greater rates of complete CSU symptom control compared with subjects in the placebo arm. The proportion of those reaching HSS = 0 and ISS = 0 remained higher in the treatment cohort throughout this early treatment period.

Safety results from the pooled analysis were also described as consistent with previous reports from the REMIX program. Remibrutinib was generally well-tolerated, with a lack of new safety concerns being identified.

Overall, these data reinforce earlier findings from the phase 3 research, highlighting not only the efficacy and safety of remibrutinib but also its rapid onset of action. The drug’s ability to attain early symptom control may be particularly meaningful for those with CSU who continue to experience significant burden despite standard antihistamine use.

Early symptom improvement with remibrutinib in chronic spontaneous urticaria: Daily Itch Severity Scores and Hives Severity Scores from phase 3 REMIX-1/-2 studies. Poster presented at: 2026 American Academy of Dermatology Annual Meeting; March 27–31, 2026; Denver, CO. Poster DV-018384.

Metz M, Giménez-Arnau A, Maurer M, et al. Remibrutinib in Chronic Spontaneous Urticaria. N Engl J Med. 2025 Mar 6;392(10):984-994. doi: 10.1056/NEJMoa2408792. PMID: 40043237.

Tbakhi B, Ware K, Bernstein JA, et al. An Overview of Chronic Spontaneous Urticaria: Diagnosis, Management, and Treatment. Allergy Asthma Immunol Res. 2025 Sep;17(5):531-546. doi: 10.4168/aair.2025.17.5.531. PMID: 41044830; PMCID: PMC12511800.

Articles

These data from REMIX-1 and 2 suggest remibrutinib, in those with chronic spontaneous urticaria (CSU), can lead to fast, early symptom control.

Urticaria

The HCPLive urticaria page is a comprehensive resource for clinical news and insights on chronic idiopathic urticaria and chronic spontaneous urticaria. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for urticaria, and more.

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The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

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 conference coverage page features articles, videos, and expert-led live coverage from major medical meetings throughout the year.

REMIX: Early CSU Symptom Improvement Observed with Remibrutinib Therapy

Monica Kraft, MD, is Murray M. Rosenberg Professor of Medicine and System Chair for the Department of Medicine at Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai.

AI-Enhanced ECGs Detect Early COPD, With Monica Kraft, MD

Recent research suggests that routine electrocardiograms (ECGs) analyzed through artificial intelligence (AI) may offer a scalable approach to identifying early 

, Monica Kraft, MD, of the Icahn School of Medicine at Mount Sinai, discussed key findings from a new study that assessed the accuracy of an automated COPD diagnosis using deep learning on ECGs.

“A lot of patients, especially as the years go by, undergo cardiology evaluation and don't necessarily have the lungs evaluated similarly,” Kraft said. “[This tool] may allow us to bring other issues to light.”

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide. The non-specific symptoms and reliance on time- and resource-intensive testing often delay a diagnosis.

Kraft and colleagues analyzed ≥ 760,000 ECGs across multiple hospital systems and the UK Biobank using a convolutional neural network, demonstrating robust performance in detecting COPD (area under the curve, 0.80–0.82). Kraft emphasized the role of subtle P wave changes as early indicators of COPD.

“The lungs and the heart are very interrelated,” she explained. “The heart is very subject to pressure changes that go on in the lung. COPD starts in [the] smallest [lung branches]. They can be a millimeter in size. The air that we breathe can get into those little airways, but has trouble getting out because those small airways are closed off. And so, those little airways don't empty as well. They hold on to this air, and the lungs get a little bit bigger than they should. That size change…can be very subtle, [and] early on, alters the pressure between the lungs and the heart and also the lungs and the ribs, the chest wall and the diaphragm, all these relationships get altered. Those…subtle pressure changes, we think, actually have an impact on the P wave.”

The model performed well in patients with documented smoking histories, underscoring its relevance to populations at greater risk. Kraft noted potential future applications for other obstructive airway diseases, such as asthma, cystic fibrosis, and bronchiectasis, although further study is needed.

If applied across a health system, Kraft said the algorithm could flag possible COPD on routine ECGs. Cardiologists could note this, prompting primary care providers to initiate further evaluation or pulmonology referral. This could lead to earlier intervention and improved outcomes.

She cautioned that the model is not perfectly specific. Only about 70% of flagged ECGs corresponded to confirmed COPD. Kraft said that a prospective evaluation will be important to define disease severity and guide clinical response before widespread deployment.

Despite limitations, Kraft highlighted the promise of AI-enhanced ECGs, which are inexpensive and easily accessible. Early detection of COPD could slow lung function decline, reduce hospitalizations, and improve survival. This study supports AI-based ECG as a tool for early COPD recognition, complementing traditional diagnostic methods such as spirometry.

“We need to remember that we also are at the early stages of this approach,” Kraft said. “We can identify COPD early, but we need to now understand what is the extent of the disease that we're identifying. We know a little bit about that from the chart review, but what we want to do is bring those patients in live and do an evaluation so that we can describe the type of COPD that we are identifying. Those are all pieces that are in the works…before it becomes a decision support tool at the ECG level, we would need to sort all of that out.”

Part 1 of our interview with Kraft can be viewed 

Vaid A, Sharma J, Jiang J, et al. Automated diagnosis of chronic obstructive pulmonary disease using deep learning applied to electrocardiograms. 

Videos

Deep learning applied to routine ECGs identifies subtle cardiac signals linked to early COPD, potentially enabling earlier diagnosis and intervention.

Pulmonology

Infectious Disease condition center page is a comprehensive resource for clinical news and insights on respiratory health. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for asthma, COPD, interstitial lung disease, COVID-19, and more.

COPD

COPD condition center page, resources on the topics of medical news and expert insight into chronic obstructive pulmonary disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on COPD research, treatment, and drug development.

VELA: Phase 3 Data Suggest Sonelokimab Effective for HS, With Alexa Kimball, MD, MPH

 suggest sonelokimab may deliver sustained clinical and quality-of-life improvements for adults with moderate-to-severe hidradenitis suppurativa (HS).

These findings resulted from the phase 3 VELA-1 and VELA-2 trials. In an on-site interview, VELA trial investigator Alexa Kimball, MD, MPH, of Harvard Medical School, discussed the broader implications of these findings, including how higher response thresholds like Hidradenitis Suppurativa Clinical Response (HiSCR) 75 may help redefine treatment goals and expectations in HS management.

“What was great to see in the data…is that the efficacy seems to be quite have a very high slope at the beginning of treatment and then continues to improve over time through Week 40 with hidradenitis suppurativa,” Kimball expressed.

838 individuals were assessed in the global VELA program, with investigators utilizing the more stringent HiSCR 75 as their primary endpoint, reflecting at least a 75% reduction in patients’ abscess and inflammatory nodule count without worsening of abscesses or draining tunnels. Kimball et al found, by Week 40, approximately 62% of those on sonelokimab attained HiSCR75, with up to 32% achieving complete lesion clearance (HiSCR100).

These findings were described as consistent across both analyses, suggesting a high level of durable disease control with the drug’s use. Additional measures of HS severity and symptom burden also demonstrated meaningful improvement, Kimball and colleagues found. Up to 77% of those evaluated achieved at least a 55% reduction in International HS Severity Scoring System (IHS4-55), and approximately a quarter reached inflammatory remission. Such outcomes point to substantial reductions in inflammatory activity.

Notably, Kimball and coauthors’ clinical gains were accompanied by notable improvements in the patient-reported outcomes seen in the VELA program. Quality-of-life scores, as determined by the HS Quality of Life (HiSQOL) instrument, were found to have risen significantly through the 40-week mark, with many individuals on the drug transitioning from severe baseline impairment to mild or no impact.

Additionally, the investigators noted improvements across key functional and emotional domains, including mobility, pain, and mood. Kimball and colleagues also found up to 43% of subjects reported clinically meaningful reductions in their level of pain, and roughly two-thirds achieved meaningful improvements in Dermatology Life Quality Index (DLQI) scores.

The safety profile of this medication was shown to be consistent with earlier findings, with Kimball et al finding no new safety signals over 40 weeks of treatment.

Kimball’s institution received grants from Abbvie, Admirx, Anapyts Bio, Aristea, Bristol Myers Squibb, Chemocentryx, Eli Lilly, Incyte, Janssen, MoonLake, Novartis, Pfizer, Prometheus, UCB; Sonoma Bio. Kimball received consulting fees from Abbvie, Alumis, Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Eli Lilly, Janssen, Moonlake Novartis, Pfizer, Priovant, Sonoma Bio, Sanofi, UCB; Target RWE, Ventyx; and serves on the board of directors of Almirall.

MoonLake announces Week 40 Results from its Phase 3 Clinical Trials of Sonelokimab in Hidradenitis Suppurativa at the 2026 AAD Annual Meeting. MoonLake. March 28, 2026. Accessed March 30, 2026. 

https://www.globenewswire.com/news-release/2026/03/28/3264203/0/en/MoonLake-announces-Week-40-Results-from-its-Phase-3-Clinical-Trials-of-Sonelokimab-in-Hidradenitis-Suppurativa-at-the-2026-AAD-Annual-Meeting.html

Kimball A. Sonelokimab in moderate-to-severe HS: long-term results through week 40 of two phase 3 trials. Presented at: 2026 American Academy of Dermatology Annual Meeting; March 27-31, 2026; Denver, CO.

This interview highlights phase 3 findings on sonelokimab for individuals with hidradenitis suppurativa (HS).

Hidradenitis Suppurativa

Hidradenitis Suppurativa condition center page, audiences can find a variety of coverage mediums for medical news and updates, including articles, video interviews, podcasts, and breaking news on dermatology research, treatment, and drug development.

Pranav Garimella, MBBS, MPH, is chief medical officer of the American Kidney Fund.

How Rewriting Race-Based GFR Equations Changed Kidney Transplant Access

Implementing wait time modifications for Black transplant candidates who were negatively impacted by race-based GFR equations was associated with an increase in transplant rates, according to new data from a national policy shift.

"Prior to 2021, lab reports typically reported two GFR values, one for people who identified as Black or African American, and another estimate for everyone else," Pranav Garimella, MBBS, MPH, Chief Medical Officer of the American Kidney Fund and an associate professor of medicine at UC San Diego, told HCPLive. "This was based on studies that found that people who identified as Black have higher levels of creatinine in their blood. What ended up happening was that race-based equations systematically assigned a higher GFR value to Black patients."

In 2023, the Organ Procurement and Transplantation Network (OPTN) implemented a national policy to add wait-time modification for Black candidates who were disadvantaged by eGFR equations with racial coefficients. This policy change sought to correct race-based biological assumptions that had informed clinical decision-making for decades.

“The decisive action required all transplant centers to review their wait lists and submit wait time modifications to persons who identified as black,” Garimella said. “This was really a restorative policy to bring back some level of equity to the transplant wait lists.”

For almost 4 decades, clinicians utilized different eGFR algorithms to estimate the kidney function of patients who identified as black compared to those who were white or within other racial groups. Two widely used equations, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease Study (MDRD), incorporated 1.159 and 1.210 coefficient factors for black patients, respectively. Ultimately, this led to higher assigned eGFR values for black patients compared to white patients.

The use of higher eGFR values suggested better kidney function in Black individuals than was actually present. This misestimation created barriers to care, including delayed evaluation and specialist referral, ultimately contributing to worse health outcomes. By the time patients presented with kidney failure, delays in referral and evaluation often meant they were listed for transplant later, reducing accrued wait time and delaying transplantation.

To assess the impact of this policy on transplantation rates, study investigators conducted a quasi-experimental study, analyzing an OPTN database of 181,314 adult kidney transplant candidates who were actively waitlisted. This included 56,344 Black candidates (31.1%) and 124,970 candidates of all other racial and ethnic groups, including American Indian/Alaska Native, Asian, Hispanic/Latino, Native Hawaiian/Other Pacific Islander, White, multiracial, and unknown (68.9%).

Among these, 21,119 transplant candidates received wait time modifications, which added a median (IQR; range) of 1.7 (0.9-3.0; 0-21.2) years, and a total of 51,061 person-years of waitlist time. In interrupted time series analyses, among Black candidates, policy implementation was associated with an increase of 5.3 transplants per 1000 listings (95% Confience Interval [CI], 3.5 to 7.0), with decreasing transplant rates thereafter (−0.10 transplants per 1000 listings per month; 95% CI, −0.17 to −0.03).

Among all other candidates, implementation was associated with no significant change in overall transplant (0.6 transplants per 1000 listings; 95% CI, −1.8 to 0.7) and a parallel decreasing trend thereafter (−0.10 transplants per 1000 listings per month; 95% CI, −0.15 to −0.05). In secondary analyses, policy implementation was associated with increased overall and DDKT rates among Black preemptive and postdialysis candidates, no significant changes in LDKT for either group or DDKT for non-Black and/or Hispanic candidates, and a small secular increase in overall transplant rates.

These findings underscore the need for equitable kidney function assessment practices to ensure timely access to evaluation, transplant listing, and ultimately, improved outcomes.

Editor’s Note: Garimella has relevant disclosures with Otsuka and the PKD Foundation.

Khazanchi R, Fleishman A, Eneanya ND, et al. Wait Time Modifications for Black Transplant Candidates Affected by Race-Based Kidney Function Estimation. 

. Published online September 2026:e260001. doi:

https://doi.org/10.1001/jamainternmed.2026.0001

Dinushika Mohottige, Opeyemi Olabisi, L. Ebony Boulware. Use of Race in Kidney Function Estimation: Lessons Learned and the Path Toward Health Justice. 

https://doi.org/10.1146/annurev-med-042921-124419

Schmidt IM, Waikar SS. Separate and Unequal: Race-Based Algorithms and Implications for Nephrology. 

Journal of the American Society of Nephrology

Garimella discusses the history, clinical impact, and rationale for removing race-based GFR from clinical decision-making.

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

Chronic Kidney Disease

How Rewriting Race-Based GFR Equations Changed Kidney Transplant Access, With Pranav Garimella, MBBS, MPH

Michael E. Thase, MD, of the University of Pennsylvania

Single-Day GH001 Produces Rapid Remission in TRD, With Michael E. Thase, MD

A single-day, individualized dosing regimen of inhaled mebufotenin (GH001) was associated with rapid and substantial reductions in depressive symptoms among adults with 

, with more than half of treated patients achieving remission by day 8.

In an interview with HCPLive, Michael E. Thase, MD, from the Perelman School of Medicine at the University of Pennsylvania, provided a clinical perspective on the magnitude of effect and considerations for interpreting the findings.

In the randomized, double-blind phase 2b trial of 81 patients, participants were assigned 1:1 to GH001 (n = 40) or placebo (n = 41) and received up to 3 escalating inhaled doses (6 mg, 12 mg, and 18 mg) within a single day. The primary endpoint, which was the change in Montgomery-Åsberg Depression Rating Scale (MADRS) score from baseline to day 8, favored GH001, with a least squares mean difference of −15.5 points compared with placebo (

 < .001; effect size, −2.0). Remission (MADRS ≤10) occurred in 57.5% of patients in the GH001 group versus 0% in the placebo group, corresponding to a number needed to treat of 2. Response rates were 60.0% and 0%, respectively.

“The effect size is the effect of the active treatment divided by the effect of the inactive treatment,” Thase explained. “When the placebo has little effect, you can have a very large effect size. A little more than half of the patients who received…GH001 got substantially better quickly, and no one in the placebo group [did]. The fact that it's about [a] 55% rapid remission is a wonderful thing.”

He added that while the observed remission rate is clinically meaningful, placebo response rates are likely to increase in larger phase 3 trials.

The study’s design may have contributed to the lack of placebo response. GH001 produces a short-duration psychoactive experience, with a median duration of approximately 9 to 14 minutes across doses, allowing for repeated dosing within a single treatment session. Patients who did not achieve a sufficient psychoactive effect were eligible for up to 2 additional doses at 1-hour intervals. All placebo-treated participants received 3 administrations without meaningful psychoactive effects.

“If you got randomized to placebo…you got 3 duds,” Thase said. “You had 3 times the chance to say, ‘hey, this isn't the real thing.’ I don’t think that 50 plus percent remission rate is just a glorified placebo response, but I do think that the 0% absence of real benefit in the placebo arm reflects the fact that folks were expecting a psychedelic experience. By the end of that long morning, they deduce that they lost the coin flip in this study.”

He described this as functional unblinding, a recognized challenge in psychedelic trials, particularly when subjective effects are closely linked to therapeutic outcomes. The US Food & Drug Administration (FDA) brought up this concern with psychedelics during the advisory committee meeting for MDMA-assisted therapy to treat PTSD.

To reduce bias, efficacy assessments were conducted by independent raters who were not involved in treatment administration and were unaware of patients’ subjective experiences.

 Patients were instructed not to disclose details of their psychoactive response. Despite these measures, Thase acknowledged the limitations of maintaining blinding in this context and noted that regulators have raised similar concerns in prior evaluations of psychedelic therapies.

Beyond the double-blind phase, all 41 placebo non-responders received GH001 in the open-label extension and demonstrated response rates comparable to those initially assigned to active treatment, according to Thase.

“That kind of internal replication within a study is really reassuring that there’s something substantial here,” he said.

Secondary endpoints also favored GH001, with improvements observed in anxiety symptoms, global illness severity, and quality of life measures by day 8. The treatment was generally well tolerated. Treatment-emergent adverse events occurred in 72.5% of patients receiving GH001 and 7.3% receiving placebo, with nausea, salivary hypersecretion, and paresthesia among the most frequently reported events. All adverse events were mild or moderate, and no serious adverse events, discontinuations, or deaths were reported.

Follow-up data from the 6-month extension phase suggest that remission can be maintained with intermittent retreatment. Among patients who achieved remission at day 8, 87% remained in remission at 6 months, typically with limited additional dosing.

For clinicians, Thase emphasized focusing on the observed remission rate rather than the magnitude of the effect size alone.

“A rapid 50-plus percent remission rate is a really good thing,” he said. “Let's hope that…[a] positive result is confirmed in phase 3.”

Cubala WJ, Bajbouj M, Bauer M, et al. GH001 vs Placebo in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial. 

Kunzmann K. FDA Psychopharmacologic Advisory Committee Votes Against Supporting Effectiveness of MDMA for PTSD. HCPLive. Published on June 4, 2024. Accessed on March 31, 2026. 

https://www.hcplive.com/view/live-updates-fda-psychopharmacologic-advisory-committee-meeting-mdma-ptsd

Inhaled GH001 achieved 57.5% remission by day 8 in TRD with a large effect size vs placebo; Thase discusses interpretation, unblinding, and phase 3 implications.

Psychiatry

Psychiatry condition center page is a comprehensive resource for clinical news and insights on mental illnesses. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for depression, schizophrenia, bipolar disorder, anxiety, and more.

Major Depressive Disorder

Major Depressive Disorder condition center page, resources on the topics of medical news and expert insight into depression can be found. Content includes articles, interviews, videos, podcasts, and breaking news on MDD research, treatment, and drug development.

Podcasts

David Cherney, MD, PhD, discusses REMODEL trial insights into how semaglutide reduces albuminuria and impacts kidney fat and fibrosis pathways.

podcasts page features a feed of medical news and interview podcast series, including DocTalk, Lungcast, Derm Discussions, and Heart Trials.

Kidney Compass: Navigating Clinical Trials

Hosted by Brendon Neuen, MBBS, PhD, and Shikha Wadhwani, MD, MS, Kidney Compass: Navigating Clinical Trials is a regular podcast exploring and breaking down the latest updates and nuances of clinical trials in nephrology. By listening to Kidney Compass, you'll get the guidance you need to navigate the changing landscape of clinical trials across the spectrum of kidney disease. 

Kidney Compass: REMODEL Trial Provides Mechanistic Rationale for Semaglutide in CKD

Martin de Borst, MD, PhD, discusses IV iron use in transplant recipients through an RCT focused on exercise capacity, function, and quality of life.

Kidney Compass: IV Iron and Functional Outcomes in Kidney Transplant Recipients

Katherine Tuttle, MD, is Executive Director for Research at Providence Inland Northwest Health and Professor of Medicine at the University of Washington.

REMODEL reveals how semaglutide protects kidneys, showing reduced inflammation, improved vascular health, and evidence of structural repair in diabetic CKD.

Endocrinology

The HCPLive endocrinology page is a comprehensive resource for clinical news and insights on endocrine system conditions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for diabetes, hormonal disease, and more.

Type 2 Diabetes

From FLOW to REMODEL: Understanding Semaglutide in CKD, With Katherine Tuttle, MD

This interview highlights new 12-month, real-world data on tralokinumab and its long-term efficacy in patients with skin of color who live with atopic dermatitis.

Atopic Dermatitis

Atopic Dermatitis condition center page, audiences can find a variety of coverage mediums for medical news and updates, including articles, video interviews, podcasts, and breaking news on dermatitis research, treatment, and drug development.

TRACE: Tralokinumab Data for Atopic Dermatitis in Skin of Color, With April Armstrong, MD, MPH

Thierry Passeron, MD, PhD, is a professor and chair of the Department of Dermatology at the Université Côte d'Azur in Nice, France.

Patients with non-segmental vitiligo (NSV) on upadacitinib versus placebo showed continuous improvement over 48 weeks with no plateau.

Vitiligo

Vitiligo condition center page is a comprehensive resource for clinical news and insights on the dermatologic condition. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for the affected skin of vitiligo patients.

Upadacitinib Safe, Effective Over 48 Weeks for Non-Segmental Vitiligo, With Thierry Passeron, MD, PhD

Dominic Sisti, PhD, is an associate professor in the Department of Medical Ethics & Health Policy and the director of the Scattergood Program for the Applied Ethics of Behavioral Health Care. Sisti is also the host of 

, our monthly multimedia series on medical ethics in modern healthcare. 

As patients increasingly turn to ChatGPT for mental health support, psychiatrists and ethicists weigh the clinical risks, ethical concerns, and what clinicians should do next.

Schizophrenia

The HCPLive schizophrenia page is a resource for medical news and expert insights on the mental disorder. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for schizophrenia, and more.

Your Patient's New Therapist Is an AI. Now What?

Patrick Campbell is the editorial director of HCPLive. Patrick has spent years spearheading coverage surrounding cardiometabolic health and rheumatic disease for MJH Life Sciences. Before joining MJH Life Sciences in 2019, he spent time as a beat reporter and/or multimedia specialist with the Pocono Record, Star News Group, and NJ Advance Media. He is the executive producer for multiple HCPLive podcasts, including Diabetes Dialogue, Don't Miss a Beat, Kidney Compass, Medical Ethics Unpacked, The Medical Sisterhood, and Skin of Color Savvy. 


Follow him on Twitter @RealPatCampbell or reach him via email at PCampbell@mjhlifesciences.com.

New information from the phase 3 SCOUT-HCM trial indicate the benefits of mavacamten may extend to adolescents as well as adults. 

Cardiomyopathy

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

Mavacamten Shows Benefit for Pediatric Patients in SCOUT-HCM Trial

Chovatiya discussed new data showing significant EASI improvements across moderate and severe atopic dermatitis.

REZOLVE-AD: Rezpegaldesleukin Shows Consistent Efficacy Across Atopic Dermatitis Severity, With Raj Chovatiya, MD, PhD

Victoria Johnson joined MJH Life Sciences in 2020 and has written for NeurologyLive, CGTLive, and is now an assistant managing editor for HCPLive and RheumatologyLive. She doesn’t have enough time for her numerous hobbies. You can reach her at vjohnson@mjhlifesciences.com.

Results from the phase 3 trial were published in NEJM and simultaneously presented as a late-breaking abstract at AAD 2026.

VALOR: Brepocitinib AAD Data Support Priority Review for Dermatomyositis

Nicholas Marston, MD, MPH, is a cardiologist and an assistant professor of medicine at Brigham and Women's Hospital.

Marston discusses his sub analysis of the VESALIUS-CV trial, which indicated reduced MACE risk in patients with diabetes and no atherosclerosis after evolocumab treatment.

Latest News

REMIX: Early CSU Symptom Improvement Observed with Remibrutinib Therapy

AI-Enhanced ECGs Detect Early COPD, With Monica Kraft, MD

VELA: Phase 3 Data Suggest Sonelokimab Effective for HS, With Alexa Kimball, MD, MPH

How Rewriting Race-Based GFR Equations Changed Kidney Transplant Access, With Pranav Garimella, MBBS, MPH

Single-Day GH001 Produces Rapid Remission in TRD, With Michael E. Thase, MD