Ryan Livingston joined the MJH Life Sciences team in March of 2025, shortly after graduating from TCNJ with a bachelor’s degree in English. He enjoys creative writing, reading, and scuba diving. He can be reached at rlivingston@mjhlifesciences.com.

American College of Cardiology (ACC) Scientific Sessions 2026

 saw the presentation of a slew of major, practice-changing studies and trials. Between fractional flow reserve (FFR) angiography in patients with coronary artery disease (CAD) from the ALL-RISE trial to mavacamten’s positive efficacy data in adolescent patients with 

obstructive hypertrophic cardiomyopathy (oHCM)

, major data was presented for just about every major disease state in cardiology.

In light of the sheer volume of new research, the editorial team at 

 has collected 6 of the most practice-changing results from ACC.26. Catch up on any major study data you may have missed during the conference below:


FFR Angiography Noninferior to Pressure-Wire Strategy in CAD Analysis, With William Fearon, MD


Presented by William Fearon, MD, professor of medicine and director of interventional cardiology at Stanford, the ALL-RISE study proved the noninferiority of angiography-guided FFR compared to a pressure-wire-guided strategy in patients with CAD. Enrolling a total of 1930 patients, the trial demonstrated a 98.5% success rate for FFR angiography compared to a 98.6% success rate for pressure-wire-based measurements. The mean time to calculate the assessment was 6 minutes in the FFRangio group and 8 in the pressure-wire group.


SCOUT-HCM: Mavacamten Outperforms Placebo in Adolescents With HCM, With Joseph Rossano, MD, MS


Mavacamten successfully demonstrated greater reductions in left ventricular outflow compared to placebo in adolescent patients with oHCM in the SCOUT-HCM trial. Joseph Rossano, MD, MS, co-director of the Cardiac Center at the Children’s Hospital of Philadelphia, presented the data at ACC.26, demonstrating the drug’s efficacy among 44 patients. Mean Valsalva left ventricular outflow tract gradient ultimately decreased by 48.5 mmHg in the mavacamten arm compared to -0.5 mmHg in the placebo arm, and Rossano and colleagues ultimately reported few significant adverse events.


Ultrasound-Facilitated Catheter-Directed Fibrinolysis Reduces Early Decompensation in Pulmonary Embolism


The HI-PEITHO study, investigating ultrasound-facilitated, catheter-directed fibrinolysis with anticoagulation in patients with acute, intermediate-risk pulmonary embolism (PE), has demonstrated the system’s superiority to anticoagulation alone. Among 544 patients, this catheter intervention substantially reduced the risk of early clinical deterioration – a combination outcome of incidence of PE-related death, cardiorespiratory decompensation or collapse, and symptomatic PE recurrence within 7 days occurred in 11 patients in the intervention arm compared to 28 in the control group.


CHAMPION-AF: Left Atrial Appendage Closure Noninferior to NOACs


The CHAMPION-AF trial demonstrated the noninferiority of device-based left atrial appendage closure (LAAC) compared to non-vitamin K antagonist oral anticoagulant (NOAC) therapy in preventing adverse events in patients with 

. The trial enrolled 3000 patients with non-valvular AF at elevated stroke risk, who were then randomized to either the Watchman FIx device or an approved NOAC. Ultimately, a composite primary efficacy endpoint cardiovascular death, stroke, or systemic embolism occurred in 81 patients among the device group and 65 in the NOAC group, resulting in a difference of 0.9 percentage points.


Don't Miss a Beat: MRA Updates at ACC 2026 Scientific Sessions


SPIRIT-HF ultimately showed that spironolactone did not significantly reduce a composite endpoint of 

 hospitalization and cardiovascular death compared to placebo in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF). In actuality, patients administered spironolactone saw an increase in hospitalizations and severe adverse events, potentially raising questions about the safety of the drug in HFpEF and HFmrEF. However, investigators noted high discontinuation due to the COVID-19 pandemic, potentially influencing the study’s capacity to conclusively demonstrate differences between the groups.


IVUS-CHIP: IVUS-Guided PCI Fails to Demonstrate Superiority in Complex Coronary Arteries

Among 2020 patients with complex coronary arteries, randomly assigned in a 1:1 ratio to either IVUS-guided PCI or angiography-guided PCI, target-vessel failure occurred in 14% of patients in the IVUS arm compared to 11% in the angiography arm. The trial failed to demonstrate IVUS-guided PCI’s superiority to angiography, with complications occurring in 11.3% of the IVUS group and 10.2% of the angiography group. Investigators ultimately declared that the industry is not currently capable of leveraging intravascular imaging data to guide PCI in a manner that justifies the increased complexity and cost of the procedure.

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Catch up on data from some of the most impactful trials presented at the American College of Cardiology 2026.

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ACC.26 Recap: 6 Practice-Changing Trials to Know

The first quarter of 2026 brought a series of notable US Food and Drug Administration (FDA) approvals, highlighting continued momentum in innovation across diverse therapeutic areas, including rare diseases, endocrinology, dermatology, psychiatry, and hepatology. A recurring theme was the expansion of treatment options for underserved populations, particularly pediatric and rare disease communities, alongside a growing emphasis on more convenient, patient-centered care.

Several decisions marked important firsts, including the first approved therapies for conditions like pediatric acquired thrombotic thrombocytopenic purpura (aTTP), cerebral folate deficiency, and acquired hypothalamic obesity. The FDA also advanced novel therapeutic approaches, with approvals introducing new mechanisms and classes, as well as first-in-indication treatments poised to reshape care in areas like psoriasis and cholestatic pruritus in primary biliary cholangitis (PBC).

At the same time, the quarter reflected ongoing progress in optimizing existing therapies, with higher-dose options, new pediatric indications, and innovations in drug delivery aimed at improving adherence and quality of life.

Check out this Q1 2026 FDA news month in review for a recap of HCPLive’s coverage of the top FDA approvals and research from the past few months:

FDA Approves Caplacizumab-yhdp (Cablivi) as First Pediatric aTTP Therapy

: Pediatric patients ≥ 12 years of age with aTTP in combination with plasma exchange and immunosuppressive therapy

: Approval supported by efficacy data from a retrospective chart review study of 30 patients 2-18 years of age showing 80% of patients achieved clinical remission. Builds upon caplacizumab’s initial 2019 approval for adults with aTTP and makes caplacizumab the first treatment for pediatric aTTP.

FDA Approves ProlivRx, First At-Home Neuromodulation Device for MDD

: Adults with major depressive disorder (MDD) who did not respond to ≥ 1 antidepressant

: Supported by clinical evidence from the MOOD Study, a randomized, controlled, multicenter clinical trial, evaluating Proliv Rx in MDD with inadequate response to antidepressant medications.

FDA Approves First Dual-Agent Eye Drop for Near Vision Loss

: Supported by results from a pair of pivotal phase 3 trials, BRIO I and BRIO II, conducted in adults with presbyopia. Represents the first regulatory authorization of a fixed-dose, dual-agent topical therapy for age-related near vision degradation.

FDA Approves ET-600 Desmopressin Acetate (Desmoda) for Central Diabetes Insipidus

: Central diabetes insipidus in pediatric patients

: Marks the first and only FDA-approved oral liquid formulation of desmopressin

FDA Approves 3 New Pediatric Indications for Once-Weekly Somapacitan-beco (Sogroya)

: Children ≥ 2.5 years of age with Idiopathic Short Stature (ISS), short stature born Small for Gestational Age (SGA) and with no catch-up growth by 2 years of age, or growth failure associated with Noonan Syndrome (NS)

: Supported by data from the REAL8 study as part of the ongoing REAL clinical trial program.

FDA Grants Accelerated Approval to Navepegritide for Achondroplasia in Children Aged 2 Years and Older

: Children ≥ 2 years of age with achondroplasia and open epiphyses

: Based on improvements in annualized growth velocity (AGV) from 3 phase 3 trials, with continued approval contingent on confirmatory evidence of clinical benefit

FDA Approves Leucovorin Calcium (Wellcovorin) Tablets as First Cerebral Folate Deficiency Treatment

: Adult and pediatric patients who have a confirmed variant in the folate receptor 1 gene (CFD-FOLR1)

: Based on a systematic review of the published literature on the topic, including published case reports with patient-level information, as well as mechanistic data

FDA Approves Secukinumab for Pediatric Patients 12 Years and Older with HS

: Moderate to severe hidradenitis suppurativa (HS) in pediatric patients ≥ 12 years of age

: Approval makes it the only IL-17A inhibitor for this population, adding a differentiated biologic option to an area where treatment choices for younger patients have historically been limited

Icotrokinra, an Oral Il-23 Inhibitor, Receives FDA Approval for Psoriasis

: Moderate to severe plaque psoriasis in adults and pediatric patients ≥ 12 years of age weighing ≥ 40 kg who are candidates for systemic therapy or phototherapy

: Marks the first for an oral targeted peptide selectively blocking the IL-23 receptor and introduces a new mechanistic class to the psoriasis treatment landscape backed by data from multiple trials in the phase 3 ICONIC program

FDA Approves Higher Dose Semaglutide (Wegovy HD) Injection 7.2 mg for Obesity

: To be used along with a reduced calorie diet and increased physical activity to help adults with obesity lose weight and keep it off, provided they have tolerated the 2.4 mg dosage for ≥ 4 weeks and additional weight reduction is clinically indicated

: Based on results from the STEP UP trial program, a phase 3b 72-week randomized, double-blinded, placebo-controlled and active-controlled superiority trial designed to evaluate the efficacy and safety of semaglutide injection 7.2 mg compared to semaglutide injection 2.4 mg and placebo as an adjunct to lifestyle intervention.

FDA Approves Linerixibat (Lynavoy) As First Treatment for Cholestatic Pruritus in PBC

: Cholestatic pruritus in adult patients with PBC

: Approval makes it the first medicine approved in the US for this indication, supported by data from the global phase 3 GLISTEN trial, which met both primary and key secondary endpoints, demonstrating significant, rapid and sustained improvements in cholestatic pruritus and itch-related sleep interference versus placebo

FDA Approves Setmelanotide (Imcivree) for Acquired Hypothalamic Obesity

: Acquired hypothalamic obesity in adults and pediatric patients ≥ 4 years of age

: Approval makes it the first and only FDA-approved therapy for this condition, based on data from the global, randomized, double-blind, placebo-controlled phase 3 TRANSCEND trial

FDA Approves Insulin Icodec (Awiqli) as First Once-Weekly Basal Insulin for Type 2 Diabetes

: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes

: Makes it the first and only once-weekly basal insulin available in the US, based on results from the ONWARDS type 2 diabetes phase 3a program, which comprised 5 randomized, active-controlled, treat-to-target clinical trials in approximately 4000 adults with type 2 diabetes.

Q1 2026 FDA actions underscored sustained innovation across rare disease, endocrinology, dermatology, psychiatry, hepatology, and ophthalmology, with multiple first-in-indication approvals. Several decisions expanded pediatric access, including first therapies for pediatric aTTP and cerebral folate deficiency, and new pediatric indications in growth disorders and hidradenitis suppurativa. Patient-centric care advances included at-home neuromodulation for antidepressant-resistant MDD, an oral liquid desmopressin formulation, and once-weekly agents for diabetes and growth hormone deficiency.

A look at 13 key FDA approvals from Q1 2026, highlighting advances in rare disease, pediatrics, novel therapies, and patient-centered innovation.

FDA News

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Q1 2026 Recap: Top FDA Approvals

4 Hematology Headlines You Missed in March 2026


Recent updates in hematology underscore simultaneous progress in therapeutic innovation, precision diagnostics, and efforts to standardize care across rare and complex blood disorders.

In polycythemia vera (PV), the US Food and Drug Administration (FDA) has granted Priority Review to rusfertide, a first-in-class hepcidin mimetic targeting iron dysregulation, based on phase 3 VERIFY and supportive long-term data demonstrating improved hematocrit control, reduced phlebotomy requirements, and symptom relief versus standard of care.

In parallel, the American Society of Hematology (ASH) has released updated guidelines for severe and very severe acquired aplastic anemia, outlining 33 recommendations and 4 good practice statements. The guidance emphasizes earlier use of genetic and diagnostic testing, individualized treatment strategies, including immunosuppressive therapy with eltrombopag, and clearer pathways to second-line care to improve outcomes in this high-risk population.

Advances in molecular diagnostics are also reshaping hematologic malignancy care, with rapid next-generation sequencing (NGS) enabling faster identification of actionable mutations to guide early treatment decisions. However, uneven access, variability in reporting, and infrastructure limitations continue to constrain real-world implementation, highlighting a persistent gap between technological capability and clinical deployment.

At the same time, workforce data highlight ongoing system-level strain, with hematology-oncology physicians treating sickle cell disease reporting higher burnout rates than peers despite similar levels of resilience. Together, these developments reflect a field advancing rapidly in scientific capability while still facing significant challenges in equitable access, implementation, and provider sustainability.

Catch up on the 4 headlines you missed from March 2026:

FDA Accepts New Drug Application for Rusfertide, Grants Priority Review In Polycythemia Vera

The FDA has accepted the New Drug Application for rusfertide and granted Priority Review, positioning the investigational therapy as a potential first-in-class option for polycythemia vera (PV). Based on phase 3 VERIFY and supportive long-term data, rusfertide demonstrated improved hematocrit control, reduced phlebotomy needs, and symptom benefits compared with standard care alone.

The hepcidin mimetic, which targets iron dysregulation underlying PV, was generally well tolerated, with mostly low-grade adverse events reported. A PDUFA decision is expected in the third quarter of 2026.

Burnout in Sickle Cell Physicians Hits 60% While Grit and Resilience Stand Strong

Burnout rates were higher among hematology-oncology physicians treating sickle cell disease (60%) versus those who do not (43%), despite similar levels of grit and resilience. Survey findings suggest systemic factors, rather than individual behaviors, are driving the disparity, with lower job pride, reduced recreation time, and compensation differences contributing to increased burnout.

Timing Is Everything: Advancing Genomic Testing in Hematologic Malignancies

Rapid next-generation sequencing (NGS) is improving precision care in hematologic malignancies by enabling timely identification of actionable mutations to guide early treatment decisions. However, adoption remains uneven, with barriers including limited expertise, inconsistent reporting, and variability in access and reimbursement across health systems.

ASH Publishes Guidelines on Diagnosis and Management of Severe and Very Severe Acquired Aplastic Anemia

ASH has released updated guidelines outlining 33 recommendations and 4 good practice statements for the diagnosis and management of severe and very severe acquired aplastic anemia.

The guidance emphasizes improved diagnostic strategies, including expanded genetic testing, and supports personalized treatment approaches such as early use of eltrombopag alongside immunosuppressive therapy and timely transition to second-line options. Aimed at improving outcomes in this rare but life-threatening condition, the recommendations also seek to expand access to appropriate therapies and standardize care across patient populations.

Regulatory and guideline activity highlights momentum across benign and malignant hematology while exposing implementation and workforce fragility. Rusfertide, a hepcidin mimetic addressing iron dysregulation in polycythemia vera, has received FDA Priority Review on phase 3 and long-term data showing superior hematocrit control, fewer phlebotomies, and symptom improvement with mostly low-grade toxicities; a PDUFA decision is expected in Q3 2026. Updated ASH guidance for severe acquired aplastic anemia prioritizes earlier genetic workup and individualized therapy, including eltrombopag with immunosuppression. Rapid NGS is accelerating actionable mutation detection, but access and reporting heterogeneity persist. Sickle cell clinicians report disproportionately high burnout.

Catch up on the hematology headlines you missed in March 2026. 

Hematology

4 Hematology Headlines You Missed In March 2026

On April 6, 2026, Amgen announced positive topline results from a phase 3 trial of teprotumumab-trbw (Tepezza), administered via an on-body injector (OBI), for the treatment of moderate-to-severe 

Tepezza was first approved by the US Food and Drug Administration in 2020 and is the first and only approved medicine for TED. It is designed to reduce proptosis and double vision – 2 hallmark symptoms of TED – and has demonstrated its efficacy across several global clinical studies. Additionally, the drug’s safety and efficacy are well-established via 6 years of real-world experience in >25,000 patients.

“These results extend and support the best-in-class efficacy of Tepezza for people living with thyroid eye disease, now with subcutaneous administration delivering IV-level efficacy,” Jay Bradner, MD, executive vice president of research and development at Amgen, said in a statement. “With a well-understood mechanism and established impact in the clinic, we can evolve how the medicine is delivered to potentially reach even more patients through a more convenient subcutaneous option.”

The present study was a randomized, double-masked, placebo-controlled, parallel-group, multicenter trial, aiming to evaluate the efficacy and safety of subcutaneously administered Tepezza in patients with active TED compared to placebo. Investigators included a primary endpoint of proptosis responder rate, measured as the percentage of participants with a ≥2mm reduction from baseline in the study eye without deterioration of proptosis in the fellow eye by week 24.

To be eligible for inclusion, patients had to have a diagnosis of moderate-to-severe active TED within 15 months and proptosis of ≥3 mm from baseline prior to TED diagnosis, among other criteria. Patients were administered Tepezza or placebo via an OBI every 2 weeks, totaling to 12 injections.

Ultimately, the trial met its primary endpoint, reflecting a statistically significant and clinically meaningful 77% proptosis response rate (76.7% Tepezza OBI vs 19.6% placebo; 

 <.0001). Additionally, the mean proptosis reduction was -3.17 mm by week 24 (-3.17mm Tepezza OBI vs -0.8 mm placebo; 

Investigators also saw significant improvements in overall responder rate, the percentage of patients achieving a Clinical Activity Score (CAS) of 0 or 1, change in diplopia as ordinal response categories, diplopia response rate, and mean change from baseline in week 24 in the Graves’ Ophthalmology Quality of Life (GO-QoL) appearance subscale, among other secondary endpoints. Despite not achieving statistical significance, the team saw a numerical trend in the mean change in baseline at week 24 in the GO-QoL visual functioning subscale favoring Tepezza OBI.

“Thyroid eye disease can be a profoundly debilitating condition, affecting not only vision but also daily functioning with symptoms like double vision and eye bulging,” Madhura Tamhankar, MD, professor of ophthalmology and neurology at the Scheie Eye Institute, University of Pennsylvania, said in a statement. “Expanding administration options through subcutaneous delivery opens the possibility of a more accessible experience for patients with thyroid eye disease and is critical to serving diverse patient needs. The potential to achieve comparable efficacy to IV makes this advancement compelling.”

Amgen. Amgen Announces Positive Topline Phase 3 Results for Subcutaneous Tepezza in Adults Living With Moderate-to-Severe Active Thyroid Eye Disease. April 6, 2026. Accessed April 6, 2026. 

https://investors.amgen.com/news-releases/news-release-details/amgen-announces-positive-topline-phase-3-results-subcutaneous

US Food and Drug Administration. FDA approves first treatment for thyroid eye disease. 

. January 21, 2020. Accessed April 6, 2026. 

https://www.prnewswire.com/news-releases/fda-approves-first-treatment-for-thyroid-eye-disease-300990621.html

Amgen reported positive phase 3 topline data for teprotumumab-trbw delivered subcutaneously via an on-body injector in moderate-to-severe active thyroid eye disease. In a randomized, double-masked, placebo-controlled trial, dosing every two weeks for 12 injections achieved a 77% proptosis responder rate at week 24, with a mean proptosis reduction of 3.17 mm, both highly significant versus placebo. Secondary endpoints improved, including CAS, diplopia metrics, overall response, and GO-QoL appearance, supporting IV-like efficacy with greater delivery convenience.

Amgen has announced positive topline results from their phase 3 trial comparing teprotumumab-trbw – administered via an on-body injector – to placebo.

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Ophthalmology

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Thyroid Disorders

Tepezza OBI Achieves Proptosis Reduction in Thyroid Eye Disease in Phase 3 Trial

Jane M. Grant-Kels, MD, is the vice chair of the Department of Dermatology and founding director of the Cutaneous Oncology Center and Melanoma Programs and a professor of dermatology, pathology, and pediatrics at the University of Connecticut Health Center.

A presentation titled ‘Making the Most of Health Information Technology: Tools for the Dermatology Practice’ was given at the 

2026 American Academy of Dermatology (AAD) Annual Meeting

Jane M. Grant-Kels, MD, was the session presenter, and she was interviewed with HCPLive about key takeaways on the topics highlighted in ths talk. Grant-Kels is known for her role as the vice chair of the Department of Dermatology, the founding director of the Cutaneous Oncology Center and Melanoma Programs, and as a professor of dermatology, pathology, and pediatrics at the University of Connecticut Health Center.

 interview Q&A features Grant-Kels discussing notable highlights from her talk at AAD 2026:

 We want to ask about your other AAD session on making the most of health information technology tools for dermatology practice. Would you tell us about some of the tools or practices that you highlight within that session?

A lot of the new tools involve artificial intelligence. Artificial Intelligence is now being used to help streamline paperwork, fill out forms, communicate with patients on the website, and is also now being used for scribe work. So very often, you'll go into a room with a new doctor or a doctor, and they'll say, ‘Do you mind if I record this session?’ Because the recording is what's required for the AI to create a note out of the conversation that you're having…Those are great things. I'm a big advocate for doctors not being afraid of AI, but embracing it and making their practices more efficient. From the patient's perspective, there are concerns, though. First, a lot of patients are afraid of artificial intelligence and that you need to get their informed consent for you to use it, particularly for an AI scribe.

Then the other big issue is privacy, because how that data is saved is complex, and as we all know, there is no such thing as 100% secure data anymore, and AI only makes that more of a difficulty, because that data, especially a visit with the doctor, where all the information is transcribed, is no longer as secure as it was when we had written records. The electronic medical record, per se, makes data available to others, but it can also be broken into. So those are the main, main issues. The other issue is access to something called distributive justice. AI is very expensive and to include and who is going to have the ability to have that part of their practice, but are going to be physicians who are practicing in more affluent areas, rather than physicians who are taking care of Medicaid patients or rural doctors who may not have access to a higher population that can pay more, so that you know the availability of all this new technology is also not going to be distributed fairly because of the cost involved.

Those are the major issues. Informed consent, autonomy, the patient's right to allow or not allow AI to be part of the visit, and distributive justice. Who's going to have access to all of these new technologies that are very expensive? Those are the major issues. Then, there's also the concern that AI is going to replace healthcare providers in some form or fashion, whether it's the physicians themselves, whether you will need fewer physicians, or it's the secretary at the front desk or the administrator who does the paperwork.

The question is, how do we embrace AI incorporated into our practices and ensure that people have job training so that they know how to use the AI and can be employed in some fashion, to assist in the healthcare system? So those are the major concerns that I'm going to bring up about the employment of the new technologies…For anybody who's called a number like you call a department store or business, and you're never talking to a human being anymore, that's beginning to happen in medicine now. You call on someone's office, and you're not talking to an answering service. You're not talking to their front desk service.

Very often, you're talking to an AI that sounds very human-like and may be answering your questions. And you know, there's a concern about accuracy, if they're deliberating with the patient, and even in some cases, giving advice to the patient. A lot of these AI services, where the patient has access to their electronic medical record and can ask questions, in many cases. Now, the initial questions may be handled by AI, and there's some concern about how accurate that is as well.

Have you noticed in particular that there is one form or another of this technology that is more widely implemented in your own practice or any other notable products you highlight in your session?

There's been an explosion of products that are available. I mean, all you have to do is type in AI and medical, you know, office care, and it explodes with different companies that you know, there are many, many companies, and I applaud them trying to streamline prior authorization. So when you come to me as a patient, and I write a prescription, the insurance company and their wisdom turns it down, and then you have to fill out a prior authorization to rationalize why you want that drug.

This is very time-consuming for offices, and so many systems now offer AI to prepare the paperwork. Of course, at the same time, the insurer is also employing AI to reject the new prior authorization that you've submitted. But there's been an explosion. The main electronic health record that a lot of people are using in hospitals is, obviously, Epic. Epic is now employing AI in some of its technology. So that's what I'm exposed to, mostly at my institution. But in the private sector, people can use whatever they want.

Do you feel there is a concern, maybe among medical residents, about AI scribes and AI note takers removing the ability to learn certain things as thoroughly?

A lot of people, historically, have worked as scribes before medical school. That's when they finished college. They're either taking some pre-med, and they're working part-time, ascribed, learning the lingo, learning the medical, electronic medical record, and those jobs are definitely at risk, and I think a lot of people who have enhanced people's education and prepared them better for medical school. There is that concern. I think, from my experience, I find residents and medical students worried about what their role will be and whether they're going to be replaced with AI, for example, in radiology. Most X-rays are read by AI and then reviewed by a radiologist in pathology.

Now, a lot of slides are reviewed by AI and then checked by a pathologist…Dermoscopic images can now be evaluated by AI. I teach courses on demoscopy, and I'm also a dermatopathologist, and residents ask, ‘Do I have to learn this if AI is going to do it for me?’ The answer is yes, because AI needs the human as well as the AI together to be a partner, because it sometimes makes mistakes, just like we as humans make mistakes. The other problem with a lot of the AI is [one that is] in dermatology. A lot of the training sets have not included all skin types, and so there's a big concern whether the AI is more prone to make mistakes with darker skin patients, because it hasn't been trained properly.

So there are a lot of concerns about the accuracy of AI, the privacy, the informed consent, the autonomy of the patient, and the role that we as physicians will have with AI as it gets better, because AI tends to get better and better. So you know, there's this always and it's learning from its mistakes. So the question is, will it someday? Will there not be a need for dermatopathologists? Will there not be a need for demoscapists? Will there not be a need for radiologists? And my answer is yes, there will be a need. It will enhance our job by circling an area with its notes on pathology. But that doesn't mean we don't look at the slide, or that we don't look at the X-ray, but there is that concern among younger physicians today.

Can you envision a world in which these new technologies enhance the jobs of some of these clinicians, so they will actually be better able to tailor things specifically toward patients a little bit more, rather than the current system?

 Physicians are in a very bad situation. Our overhead is going up, just like everybody else's, and our reimbursements have gone down. And so to keep a practice viable, physicians have been forced to see more patients. It's, believe me, doctors don't enjoy going at that speed. I do think AI might help, because it might certainly, in theory, if AI writes the note, that's more time I can look at the patient rather than staring at the computer and typing. I mean, that's the goal. If AI can synthesize and give me a synopsis of what previously happened at previous visits and give me a summary paragraph, I can go into a room more alert to what the patient's concerns are.

I mean, that is possible. But there's a limit to how fast doctors can go, because there's still that human need to come into contact with a patient, and put hands on the patient in regards to reassurance and explaining things to the patient. I do think that for AI, we need to partner with it. I also think that the system needs to change. Reimbursements need to rise with overhead, so that needs to be addressed as well, especially since AI is very expensive. These technologies are not cheap. They come at a great cost to the physician's offices. So there needs to be a compromise, because you can't keep going faster and faster and still get any.

The quotes contained in this discussion were edited for the purposes of clarity.

Grant-Kels J, et al. F062 Making the Most of Health Information Technology: Tools for the Dermatology Practice. Sesson presented at: 2026 American Academy of Dermatology Annual Meeting; March 27–31, 2026; Denver, CO.

AI-driven health IT is increasingly embedded in dermatology workflows, particularly for documentation, patient portal communication, and prior-authorization support. Adoption is tempered by ethical, operational, and equity concerns: informed consent and patient autonomy for AI scribes, heightened privacy and cybersecurity risk in recorded/transcribed encounters, and distributive justice given high implementation costs. Clinicians and trainees worry about job displacement and skill atrophy, yet the optimal model is human–AI partnership, especially where accuracy limitations and biased training datasets persist. Sustainable integration also requires reimbursement alignment with rising overhead and technology spend.

This Q&A interview at AAD 2026 highlights health information technologies and AI tools used in dermatology practices.

Tips for AI and Health Information Technology in Dermatology Practice, With Jane M. Grant-Kels, MD

Linda Stein Gold, MD, is a dermatologist at Henry Ford Health. 

Videos

In this episode, "Value of Utilizing Matching-Adjusted Indirect Comparisons (MAICs) in Psoriasis," the expert dermatologists explore the methodology behind matching adjusted indirect comparisons and their practical value in guiding evidence based treatment decisions for plaque psoriasis.

Video Series

Value of Utilizing Matching-Adjusted Indirect Comparisons (MAICs) in Psoriasis

This episode, titled "Analyzing IL-23 Inhibitors in Psoriasis," features panelists discussing the future of IL-23 targeted therapies and the practical considerations surrounding the anticipated shift toward oral treatment options in plaque psoriasis.

Analyzing IL-23 Inhibitors in Psoriasis

Stay updated with the latest healthcare breakthroughs, including FDA actions and comparative weight loss drug data, in this week’s essential news roundup.

The HCPFive: Top News for Healthcare Providers from the Week of 03/29

This Q&A interview with Grant-Kels highlights takeaways from her session on managing the needs of patients in dermatology practicers who are pregnant.

Advice for Evaluating Pregnant Patients in Dermatology, With Jane M. Grant-Kels, MD

Diana Isaacs, PharmD, is an endocrine clinical pharmacist, director of Education and Training in Diabetes Technology, and codirector of Endocrine Disorders in Pregnancy at the Cleveland Clinic.

Podcasts

This episode covers the March 26th approval of Awiqli for T2D, highlighting its high concentration and once-weekly administration.

Type 2 Diabetes

podcasts page features a feed of medical news and interview podcast series, including DocTalk, Lungcast, Derm Discussions, and Heart Trials.

Diabetes Dialogue

Diabetes Dialogue: Technology, Therapeutics, & Real-World Perspectives is a monthly podcast hosted by Diana Isaacs, PharmD, and Natalie Bellini, DNP, aimed at providing a regular roundup of the latest clinically applicable insights across diabetes and metabolic diseases, with a focus on leveraging technology to improve care.

Diabetes Dialogue: FDA Approves Novo Nordisk’s Insulin Icodec-abae (Awiqli) for T2D

Mardi Gomberg-Maitland, MD, MSc, is the director of the pulmonary hypertension program, chief clinical research officer at the Office of Clinical Research SMHS, and a professor of medicine at George Washington University.

Gomberg-Maitland addresses sotatercept’s capacity to improve pulmonary vascular and cardiac endpoints in patients with CpcPH-HFpEF.

CADENCE: Sotatercept Reduces PVR in CpcPH-HFpEF, With Mardi Gomberg-Maitland, MD, MSc

Sayna Norouzi, MD, is an assistant professor of medicine and clinical nephrologist at Loma Linda University Medical Center

Norouzi discussed the remaining challenges that come with having evolving treatment options and a robust patient population in IgAN.

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

IgA Nephropathy

The HCPLive Berger disease page is a resource for medical news and expert insights on IgA nephropathy. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in Berger disease, and more.

New Therapeutic Options Raise More Questions for IgA Nephropathy Treatment, With Sayna Norouzi, MD

Catch up on the most impactful trial readouts to come out of ACC 2026.

Hypertension

The HCPLive hypertension page is a resource for medical news and expert insights on high blood pressure. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for hypertension, and more.

Dyslipidemia

ACC 2026: Phase 2/3 Trials to Know

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

This review of new data on psoriasis treatments from AAD 2026 highlights several key trials.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

AAD 2026: 6 Psoriasis Trials to Know

Alex Hillenbrand is an assistant editor for 

. She earned her BA in English from Lafayette College in 2023 and went on to write for pop culture, entertainment, and sports media outlets before joining MJH Life Sciences in 2025. In her free time, Alex enjoys cooking, going on walks, and meeting new people. Contact her at mjhlifesciences.com.

Catch up on the guideline updates, trial news, and featured content from March 2026. 


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