Professor Stephen Nicholls is a world-renowned cardiologist, and leads the Victorian Heart Hospital (VHH) at Monash University.

Obicetrapib is Safe and Well-Tolerated in HeFH and ASCVD, With Stephen Nicholls, MD

Obicetrapib has a history of being safe and well-tolerated in patients with 

heterozygous familial hypercholesterolemia (HeFH)

atherosclerotic cardiovascular disease (ASCVD)

, based on a pooled safety analysis of the BROADWAY and BROOKLYN phase 3 trials.

American College of Cardiology (ACC) Scientific Sessions 2026

 in New Orleans, Louisiana, by Stephen Nicholls, MD, director of the Monash Velos Accelerator, program director of MonashHeart, Intensive Care and Victorian Heart Hospital, and director of the Monash Victorian Heart Institute at Monash Health.

“We saw less new onset diabetes, which we’ve seen with other CETP inhibitors, and we’ve also seen some potential favorable effects in slowing the reduction of eGFR,” Nicholls told 

 in an exclusive interview. “I think we need to understand more about potential mechanisms, but most importantly, this reassures me about safety and tolerability, and if we can combine that with better lipid effects and ultimately a reduction in cardiovascular risks, that would be great for patients.”

BROADWAY was a multinational, placebo-controlled, double-blind phase 3 trial including patients with either HeFH or established ASCVD. Additional criteria included being on maximally tolerated lipid-modifying therapy, a fasting serum LDL-C ≥55 to <100 mg/dL or non-DL-C ≥85 mg/dL to <130 mg/dL, and an estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73m2 at screening, among others. Patients were excluded if they had NYHA class III or IV 

, left ventricular ejection fraction <30%, or major adverse cardiovascular events within 3 months of screening, among other criteria.

A total of 2530 patients were included in the trial and were randomly assigned to either obicetrapib 10 mg or placebo daily for 365 days. Over the course of the study, eGFR decreased significantly more among patients receiving obicetrapib compared to placebo. LDL-C also changed by a comparatively larger amount in the obicetrapib arm (-29.9%) versus placebo (+2.7%).

The BROOKLYN trial, meanwhile, specifically investigated patients with HeFH who were on maximally tolerated lipid-modifying therapy. Patients were excluded if they had NYHA class II or IV heart failure, last known left ventricular ejection fraction <30%, or had been hospitalized for heart failure within 5 years of screening, among other criteria.

The BROOKYLN investigators enrolled 354 patients and randomly assigned them in a 2:1 ratio to either obicetrapib 10 mg or placebo daily for 365 days. During this time, patients exhibited a placebo-adjusted LDL-C change of -36.3%. Secondary endpoints included changes in apolipoprotein B and non-HDL-C, which decreased by 24.4% and 34.5%, respectively.

For the present safety analysis, Nicholls and colleagues pooled data from both trials for a total of 2880 patients. The frequency of overall treatment-emergent adverse events was similar between obicetrapib and placebo groups (60.2% vs 62%). Adverse events leading to discontinuation were 4.1% and 5.3%, respectively. Among predicted events, dizziness, headache, hypertension, and myalgia were infrequent, while new onset diabetes mellitus, worsening glycemic control, and eGFR decline occurred less frequently with obicetrapib. Additionally, macular degeneration was rare and occurred in only 1 obicetrapib recipient.

“We know that many patients don’t get to goal, and every time we update our guidelines, they tell us that high-risk patients should go lower and lower,” Nicholls said. “But every time we lower the target, we’re going to leave more and more people behind. So, we need effective therapies that we can add to statins. Obicetrapib has the potential to be that therapy.”

Editors’ Note: Nicholls reports disclosures with AstraZeneca, NewAmsterdam Pharma, Amgen, Omthera, Merck, Boehringer Ingelheim, and others.

Nelson A, Kastelein J, Hsieh A, et al. Safety of Obicetrapib: An Integrated Pooled Phase III Safety Analysis. Abstract presented at the American College of Cardiology Scientific Sessions 2026, New Orleans, LA. March 28-30, 2026.

NewAmsterdam Pharma. Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies (BROADWAY). ClinicalTrials.gov Identifier: NCT05142722. Updated September 19, 2025. Accessed April 2, 2026. 

https://clinicaltrials.gov/study/NCT05142722

Nicholls SJ, Nelson AJ, Ditmarsch M, et al. Safety and efficacy of Obicetrapib in patients at high cardiovascular risk. 

NewAmsterdam Pharma. Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies (BROOKLYN). ClinicalTrials.gov Identifier: NCT05425745. Updated June 11, 2025. Accessed April 2, 2026. 

https://clinicaltrials.gov/study/NCT05425745

Nicholls, S.J., Nelson, A.J., Ditmarsch, M. et al. Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial. 

https://doi.org/10.1038/s41591-025-04179-4

Videos

Nicholls discusses his recent pooled analysis of safety data from the BROADWAY and BROOKLYN phase 3 trials, proving the tolerable safety of obicetrapib.

News

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Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

Dyslipidemia

Atherosclerotic Cardiovascular Disease

Conference

 conference coverage page features articles, videos, and expert-led live coverage from major medical meetings throughout the year.

Strategic Alliance Partnership

Abigail Brooks is an assistant managing editor for 

She joined MJH Life Sciences in August 2023 shortly after graduating from Monmouth University where she earned her BA in Communication with a concentration in Public Relations/Journalism and later an MA in Interactive Digital Media. She enjoys traveling, running, and reading books. She can be reached at abrooks@mjhlifesciences.com.

New analyses from the phase 3 VISIONARY trial evaluating Otsuka Pharmaceutical Development & Commercialization’s sibeprenlimab-szsi (Voyxact) in adults with IgA nephropathy (IgAN) at risk for disease progression highlight clinically meaningful improvements across key markers of IgAN.

The data were presented at the 2026 ISN World Congress of Nephrology and reinforce the potential of selectively inhibiting A PRoliferation Inducing Ligand (APRIL), a central driver of disease biology, to meaningfully impact patient outcomes.

“The new VISIONARY analyses highlight the differentiated clinical profile of sibeprenlimab and the potential clinical impact of targeting a key immune driver of the disease,” John Kraus, MD, PhD, executive vice president and chief medical officer, Otsuka, said in a statement. “In addition to meaningful reductions in proteinuria, the observed improvements in hematuria provide complementary evidence of an effect on underlying disease activity. Together, these findings reinforce the potential of [sibeprenlimab] to meaningfully improve clinical outcomes for adult IgAN patients at risk for disease progression.”

Sibeprenlimab is a humanized monoclonal antibody that binds to and blocks APRIL, which plays a key role in the 4-hit process of IgAN pathogenesis and is an important initiating and sustaining factor in IgAN progression by promoting the production of pathogenic galactose-deficient IgA1 (Gd-IgA1). Inhibition of APRIL results in reduced levels of serum Gd-IgA1, which is implicated in the pathogenesis of IgAN. Sibeprenlimab is a self-administered, subcutaneous injection dosed every 4 weeks.

It was granted accelerated approval by the US Food and Drug Administration for reducing proteinuria in primary IgAN in November 2025 based on 12-month data from the VISIONARY trial showing a 54.3% placebo-adjusted reduction in geometric mean 24-hour urine protein-to-creatinine ratio (UPCR) from baseline.

Of note, the accelerated approval was based on reduction of proteinuria. It has not been established whether sibeprenlimab slows kidney function decline over the long-term in patients with IgAN, and continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory clinical trial.

The interim VISIONARY analyses presented at WCN showed a greater and faster proportion of patients achieving negative microscopic hematuria (0–5/HPF), an exploratory endpoint reflecting improvement in glomerular injury in IgAN. Among global patients with hematuria at baseline, 82.5% of patients receiving sibeprenlimab were negative for microscopic hematuria at week 48 compared with 52.6% of patients receiving placebo. Median time to achieve negativity for microscopic hematuria (0–5/HPF) was 9 weeks with sibeprenlimab versus 24 weeks with placebo.

As described in a press release from Otsuka, the findings complement robust proteinuria reductions observed with sibeprenlimab. Of note, the safety profile was comparable between sibeprenlimab and placebo.

In a previously prespecified interim analysis of the global main cohort of VISIONARY presented at the European Renal Association (ERA) congress in 2025, sibeprenlimab met the primary endpoint, demonstrating a -51.2% (

<.0001) placebo-adjusted reduction in 24-hour UPCR at 9 months.

The VISIONARY trial is ongoing to evaluate the safety and efficacy of sibeprenlimab in preserving kidney function based on estimated glomerular filtration rate slope over a 24-month treatment period.

Otsuka. Otsuka Showcases New Efficacy and Safety Data of VOYXACT® (sibeprenlimab-szsi) in Patients with IgA Nephropathy (IgAN) at the 2026 ISN World Congress of Nephrology Highlighting the Impact of APRIL Inhibition. March 25, 2026. Accessed April 2, 2026. 

https://www.businesswire.com/news/home/20260324322305/en/Otsuka-Showcases-New-Efficacy-and-Safety-Data-of-VOYXACT-sibeprenlimab-szsi-in-Patients-with-IgA-Nephropathy-IgAN-at-the-2026-ISN-World-Congress-of-Nephrology-Highlighting-the-Impact-of-APRIL-Inhibition

Campbell P. FDA Awards Accelerated Approval to Sibeprenlimab in IgA Nephropathy. HCPLive. November 25, 2025. Accessed April 2, 2026. 

https://www.hcplive.com/view/fda-awards-accelerated-approval-to-sibreprenlimab-in-iga-nephropathy

Campbell P. ERA 2025: Sibeprenlimab Halves Proteinuria in IgAN in Phase 3 VISIONARY Trial. HCPLive. June 6, 2025. Accessed April 2, 2026. 

https://www.hcplive.com/view/era-2025-sibeprenlimab-halves-proteinuria-in-igan-in-phase-3-visionary-trial

Articles

Phase 3 VISIONARY interim analyses in adults with IgA nephropathy at risk for progression show that APRIL inhibition with sibeprenlimab-szsi yields clinically meaningful improvements across disease-activity markers. Beyond previously demonstrated, large placebo-adjusted proteinuria reductions supporting FDA accelerated approval, exploratory data indicate higher and earlier rates of negative microscopic hematuria, consistent with reduced glomerular injury. Sibeprenlimab is a self-administered subcutaneous monoclonal antibody dosed every four weeks, with a safety profile comparable to placebo. Kidney function preservation remains under confirmatory evaluation.

Data presented at the World Congress of Nephrology highlight faster and higher rates of microscopic hematuria negativity with sibeprenlimab treatment.

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

IgA Nephropathy

The HCPLive Berger disease page is a resource for medical news and expert insights on IgA nephropathy. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in Berger disease, and more.

New VISIONARY Analyses Reinforce Benefits of APRIL Inhibition With Sibeprenlimab in IgAN

Eingun James Song, MD, is the director of clinical research for Frontier Dermatology. 

Key Takeaways on JAK Inhibitors and Black Box Warnings, With Eingun James Song, MD

Eingun James Song, MD, spoke in an interview with 

 about dermatologists’ evolving understanding of Janus kinase (JAK) inhibitors at the 

2026 American Academy of Dermatology (AAD) Annual Meeting

Song, director of clinical research for Frontier Dermatology, emphasized the value of contextualizing safety data and interpreting boxed warnings with an increasing level of nuance. JAK inhibitors, Song noted, have generated significant discussion in recent years, largely given various concerns surrounding safety signals identified in clinical research.

“I think it really comes down to understanding trial designs and the population that are being studied, because whenever you look at clinical data, you have to understand what population or what type of patients were in the study,” Song explained.

In his discussion, Song described boxed warnings, while important, as not unique to JAK inhibitors. He stated they should not be interpreted as definitive indicators of risk across all patient populations. Instead, clinicians should normalize their existence and focus on individualized assessments of risk. Many safety concerns linked with JAK inhibitors, including major adverse cardiovascular events (MACE), were identified in trials involving older, comorbid populations, such as those with rheumatoid arthritis.

Such individuals will likely have a higher baseline risk of adverse events (AEs) independent of JAK use, complicating direct comparisons to dermatologic patient populations. Song additionally highlighted limitations in key studies related to JAK inhibitor therapies. Importantly, he noted, real-world data in dermatologic conditions such as atopic dermatitis and alopecia areata have not demonstrated a consistent rise in AEs among those treated with JAK inhibitors when matched for demographic and clinical risk factors.

“In other words, what I tell a patient is that if you have risk factors, these things are just more likely to happen to you whether or not you take the medication,” Song said. “And based on the data that we have, which admittedly isn't perfect, it doesn't seem to be appreciably higher than what [you] have.”

Emerging data from other indications, including hidradenitis suppurativa and vitiligo, further support JAK inhibitors’ generally favorable safety profile, with Song pointing to lower rates of serious AEs/ Longer-term placebo-controlled data, including 48-week trials, may be warranted to allow for additional reassurance as the evidence base continues to grow.

For further information on this discussion, view the full interview segment posted above.

Song has reported serving as an investigator, consultant, and/or speaker for AbbVie, Alphyn Biologics, Amgen, Apogee, Arcutis, Bristol Myers Squibb, Boehringer Ingelheim, Dermavant, DermBiont, Galderma, Incyte, Janssen, LEO Pharma, MoonLake, Novartis, Ortho, Pfizer, Regeneron, Sanofi, Sun Pharmaceutical Industries, Timber Pharmaceuticals, and UCB.

Song E. F099 JAK Inhibitors in Dermatology: Identifying Ideal Candidates. Sesson presented at: 2026 American Academy of Dermatology Annual Meeting; March 27–31, 2026; Denver, CO.

Smith T. Rethinking the Black Box: JAK Inhibitors Find Their Place in Dermatology. HCPLive. October 21, 2025. April 2, 2026. 

https://www.hcplive.com/view/rethinking-black-box-jak-inhibitors-find-their-place-dermatology

Song speaks about JAK inhibitors and their safety in dermatology care settings, contextualizing previous data on adverse events.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

Chelsie Derman is an associate editor for 

who covers allergy and  psychiatry. She joined MJH Life Sciences in September 2023 after graduating from The College of New Jersey with a bachelor’s degree in journalism and professional writing. In her free time, she enjoys creative writing and reading.

FDA removes age requirement for epinephrine nasal spray

FDA grants fast track designation to bw-20805 siRNA therapy for HAE

FDA accepts NDA for bezuclastinib in non-advanced systemic mastocytosis

Viaskin peanut patch shows promise in phase 3 Vitesse trial

March 2026 brought a wave of regulatory updates and emerging therapeutic data across the 

 and immunology space, spanning anaphylaxis management, food allergy desensitization, hereditary angioedema (HAE), systemic mastocytosis, and chronic rhinosinusitis with nasal polyps (CRSwNP). Several developments centered on improving access to emergency therapies and accelerating disease-modifying approaches for IgE-mediated allergy and mast cell–driven conditions. Key updates from the month highlighted advances in noninvasive treatment options, RNA-based therapeutics, and targeted inhibitors with rapid onset of action.

This month in review spotlights the top 6 allergy news stories in March.

FDA Updates: Neffy Label Change, Fast Track for HAE Therapy, & More

FDA Removes Age Requirement for Epinephrine Nasal Spray

The US Food and Drug Administration (FDA) removed the minimum age requirement for 1 mg epinephrine nasal spray, allowing use in any patient weighing ≥ 33 lbs (15 kg). Previously, pediatric use was limited to those aged ≥ 4 years despite weight-based dosing alignment. The updated labeling now bases dosing solely on weight, expanding access to needle-free epinephrine for younger children at risk for anaphylaxis.

The revision also included practical updates, such as guidance for accidental sniffing after administration, allowances for freeze-thaw use, and expanded storage parameters, including temperature excursions up to 122°F. These changes aim to improve real-world usability in settings such as schools and childcare. Approximately 25% of children within the eligible weight range had previously been excluded due to age criteria, underscoring the clinical significance of the labeling change.

FDA Grants Fast Track Designation to BW-20805 siRNA Therapy for HAE

The FDA granted Fast Track designation to Argo Biopharmaceutical’s BW-20805, an investigational small interfering RNA (siRNA) therapy targeting the kallikrein pathway for prophylaxis of HAE. Early phase 2 findings suggest potential sustained suppression of disease activity, though investigators emphasized the preliminary nature of the data and the need for longer follow-up.

The ongoing phase 2 trial is expected to be completed in 2026, with plans for a global phase 3 study thereafter. The designation reflects the therapy’s potential as a long-acting treatment option in a disease requiring ongoing prophylaxis.

Related: BW-20805 Reduces HAE Attacks in Phase 2 Trial, With Markus Magerl, MD

FDA Accepts NDA for Bezuclastinib in Non-Advanced Systemic Mastocytosis

The FDA accepted the new drug application (NDA) for Cogent Biosciences’ bezuclastinib in adults with non-advanced systemic mastocytosis and assigned a PDUFA target action date of December 30, 2026. The agency indicated no planned advisory committee meeting and identified no major review issues at acceptance.

The submission is supported by data from the SUMMIT trial evaluating the selective KIT inhibitor (KIT D816V) in patients with mast cell–driven symptoms. The regulatory milestone signals potential progress toward a targeted oral therapy for a population with limited treatment options.

VIASKIN Peanut Patch Shows Strong Phase 3 VITESSE Results, With David Fleischer, MD

Phase 3 VITESSE trial data demonstrated strong desensitization outcomes with the VIASKIN peanut patch (VP250), an epicutaneous immunotherapy delivering 250 µg peanut protein. Among peanut-allergic children aged 4–7 years, 82.8% receiving VP250 increased their eliciting dose compared with 48% on placebo over 12 months.

The trial met its primary endpoint, with significantly greater responder rates in treated patients across baseline eliciting dose strata (46.3% vs 14.7% and 43.1% vs 14.6%, respectively; 

<.001). Additionally, 60% of participants improved by ≥ 2 dose levels during food challenge testing versus 23.4% on placebo. Investigators highlighted the patch’s noninvasive design and potential for improved adherence compared with oral immunotherapy.

“It's fantastic data to show that epicutaneous immunotherapy, [at] such a low dose, works to desensitize the vast majority of patients to a level that I think will protect them clinically from allergic reactions,” David Fleischer, MD, professor of pediatrics at Children’s Hospital Colorado, told 

Remibrutinib Enables Peanut Tolerance in as Little as 1 Week, With Robert Wood, MD

Phase 2 data presented at the 2026 AAAAI Annual Meeting demonstrated rapid desensitization with remibrutinib, a Bruton’s tyrosine kinase inhibitor. After only 1 week of treatment, 88% of adults with IgE-mediated peanut allergy tolerated a previously reactive dose during oral food challenge. The therapy was well tolerated, with no serious adverse events reported.

Across dose groups, 4 weeks of therapy produced estimated response rates ranging from 0.41 to 0.84, all exceeding placebo. In an interview, Robert Wood, MD, from Johns Hopkins Children's Center, said that the speed of remibrutinib may open up the possibility of the treatment to be used intermittently instead of continuously.

Verekitug Cuts Polyp Size in Severe CRSwNP, With Joseph Han, MD

At AAAAI 2026, HCPLive spoke with Joseph Han, MD, from Old Dominion University, on late-breaking phase 2 VIBRANT data demonstrating that verekitug, a thymic stromal lymphopoietin (TSLP) receptor–blocking therapy, reduced the need for surgery and improved outcomes in severe chronic rhinosinusitis with nasal polyps. Quarterly treatment reduced surgical need by 76% compared with baseline expectations, highlighting the biologic’s potential in severe disease management.

Han emphasized that targeting upstream epithelial cytokines such as TSLP may offer broader anti-inflammatory control compared with downstream biologics, supporting ongoing development in CRSwNP.

March 2026 allergy news: FDA label updates, mastocytosis NDA, and promising data for peanut patch, remibrutinib, and CRSwNP biologics.

Allergy

Allergy condition center page is a comprehensive resource for clinical news and insights on allergic and inflammatory diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for food and seasonal allergies, as well as allergic asthma and related conditions.

Food Allergy

Seasonal Allergy

Anaphylaxis

The HCPLive anaphylaxis page is a comprehensive resource for clinical news and insights on acute allergic reactions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for preventing anaphylaxis, and more.

6 Allergy Headlines You Missed in March 2026

Alex Hillenbrand is an assistant editor for 

. She earned her BA in English from Lafayette College in 2023 and went on to write for pop culture, entertainment, and sports media outlets before joining MJH Life Sciences in 2025. In her free time, Alex enjoys cooking, going on walks, and meeting new people. Contact her at mjhlifesciences.com.

Credit: The Aplastic Anemia and MDS International Foundation


’s new Clinical Practice Guidelines on Diagnosis and Management of Severe and Very Severe Acquired Aplastic Anemia (AA) outline 33 recommendations and 4 good practice statements for children and adults.

The guidelines focus on tools to improve diagnosis and treatment decisions, including expanded use of specialized blood and genetic tests, personalized initial treatment based on age and availability of a fully matched donor, the addition of eltrombopag to standard immunosuppressive therapy to improve blood cell counts, and earlier transition to second-line treatments after initial immunosuppression for patients who do not respond or relapse.

“It’s critical to definitively diagnose individuals with aplastic anemia to ensure that they are promptly connected to appropriate treatment,” said Phil Scheinberg, MD, head of the division of hematology at Hospital Beneficência Portuguesa Hospital in São Paulo, and chair of the ASH 2026 Guidelines for the Diagnosis and Management of Severe and Very Severe Acquired Aplastic Anemia. “We hope these guidelines will not only improve patient outcomes but also expand access to diagnostic testing and catalyze broader global access to transplant and immunosuppressive therapies.”

The rare and serious hematologic disorder, AA, is characterized by the failure of bone marrow to produce enough blood cells, which leads to pancytopenia, a serious blood condition characterized by a deficiency in the cellular components of red blood cells, white blood cells, and platelets. Often, the severe complications of aplastic anemia include profound fatigue, increased susceptibility to infections, and an increased hemorrhage risk.

In the US and Europe, the incidence of acquired AA is 2 to 3 per million people per year, and has increased rates in Asia, reported at 5–6 per million in some regions. At diagnosis, about 79.6% to 83.8% of these patients have severe or very severe disease. If treated with supportive care alone, mortality can be > 80% within 2 years due to severe neutropenia (low neutrophil count) and thrombocytopenia, leading to infection or hemorrhage.

Modern treatment strategies such as allogeneic hematopoietic cell transplantation (alloHCT), stem cell bone marrow transplants, blood transfusions or Immunosuppressive Therapy (IST) have improved these 2-year survival rates to >80%.

To create the guidelines, a multidisciplinary expert panel, including a patient with liver experience, focused on severe cases of acquired aplastic anemia, characterized by especially reduced counts of neutrophils (white blood cells, <500 per microliter), anemia with reduced reticulocytes (immature red blood cells, <60,000 per microliter), and platelets (cells necessary for clotting, <20,000 per microliter) in the blood.

The updated 2026 guidelines included eltombopag, a small molecule thrombopoetin (TPO) mimetic, as a first-line treatment option. It is approved by the 

to treat severe AA in combination with standard immunosuppressive therapy for newly diagnosed adults and pediatric patients ≥2 years of age and for patients who have exhibited an insufficient response to immunosuppressive therapy.

“The Society is proud to provide this robust and much-needed resource for clinicians caring for individuals with aplastic anemia,” said Robert Negrin, MD, ASH president. “These guidelines offer important consensus for the field while helping raise awareness of a serious, yet often overlooked, disorder.”

Scheinberg P, O’Neal DA, Basquiera AL, et al. American Society of Hematology 2026 Guidelines for the Diagnosis and Management of Severe Acquired Aplastic Anemia. Blood Advances. Published March 24, 2026. Accessed April 2, 2026. 

https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2025019051/567383/American-Society-of-Hematology-2026-Guidelines-for

Schoettler ML, Nathan DG. The Pathophysiology of Acquired Aplastic Anemia. 

Hematology/Oncology Clinics of North America

https://doi.org/10.1016/j.hoc.2018.03.001

Moore CA, Krishnan K. Aplastic Anemia. PubMed. Published 2022. 

https://pubmed.ncbi.nlm.nih.gov/30480951/

ASH 2026 clinical practice guidelines for severe and very severe acquired aplastic anemia deliver 33 recommendations and 4 good practice statements spanning pediatric and adult care. Emphasis is placed on definitive diagnosis using expanded specialized blood and genetic testing, and on tailoring first-line therapy by age and matched-donor availability. For newly diagnosed patients, adding eltrombopag to standard immunosuppressive therapy is endorsed to improve hematologic responses. For nonresponders or relapsed disease after initial immunosuppression, earlier transition to second-line strategies is recommended to optimize outcomes.

ASH publishes 33 clinical recommendations and 4 good practice statements for the diagnosis and treatment of severe and very severe acquired aplastic anemia. 

Hematology

ASH Publishes Guidelines on Diagnosis and Management of Severe and Very Severe Acquired Aplastic Anemia

Nicholls discusses the investigational oral CETP inhibitor’s effects on kidney health for patients at high risk of cardiovascular disease due to elevated HDL-C.

Chronic Kidney Disease

BROADWAY: Obicetrapib Preserves Kidney Function, Prevents CKD, With Stephen Nicholls, MD 

Marcello Tonelli, MD, is a nephrologist and professor of medicine at the University of Calgary, founding director of the World Health Organization Collaborating Centre on Prevention and Control of Chronic Kidney Disease, and president of the International Society of Nephrology.

The WHO resolution on kidney health elevates kidney disease as a global health priority, emphasizing early detection, treatment, and system-wide action.

Elevating Kidney Disease in Global Health Policy, With Marcello Tonelli, MD

Rajiv Agarwal, MD, MS, is a Professor Emeritus of Medicine at Indiana University School of Medicine and VA Medical Centre in Indianaoplis.

Further CONFIDENCE analyses support safe combination therapy in CKD, with improved responses in key patient subgroups.

CONFIDENCE Trial Insights on CKD Combination Therapy, With Rajiv Agarwal, MD, MS

Pranav Garimella, MBBS, MPH, is chief medical officer of the American Kidney Fund.

New OPTN data shows kidney transplant gains from race-free GFR and restored wait times stall, as structural barriers still limit equitable listing access.

OPTN Policy Gave Back Time, Increased Transplants for Black Kidney Candidates So Why Have Rates Plateaued?

Michael E. Thase, MD, of the University of Pennsylvania

An interview with Thase explores rapid antidepressant effects and real-world considerations for single-day individualized GH001 dosing in TRD.


Psychiatry

Psychiatry condition center page is a comprehensive resource for clinical news and insights on mental illnesses. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for depression, schizophrenia, bipolar disorder, anxiety, and more.

Major Depressive Disorder

Major Depressive Disorder condition center page, resources on the topics of medical news and expert insight into depression can be found. Content includes articles, interviews, videos, podcasts, and breaking news on MDD research, treatment, and drug development.

Single-Day GH001 for TRD Shows Rapid Response, With Michael E. Thase, PhD

Patrick Campbell is the editorial director of HCPLive. Patrick has spent years spearheading coverage surrounding cardiometabolic health and rheumatic disease for MJH Life Sciences. Before joining MJH Life Sciences in 2019, he spent time as a beat reporter and/or multimedia specialist with the Pocono Record, Star News Group, and NJ Advance Media. He is the executive producer for multiple HCPLive podcasts, including Diabetes Dialogue, Don't Miss a Beat, Kidney Compass, Medical Ethics Unpacked, The Medical Sisterhood, and Skin of Color Savvy. 


Follow him on Twitter @RealPatCampbell or reach him via email at PCampbell@mjhlifesciences.com.

Indirect data suggest oral semaglutide may reduce weight more than orforglipron, but cross-trial comparisons limit clinical interpretation.

Obesity Management

Obesity Management condition center page, resources on the topics of medical news and expert insight into clinical weight management can be found. Content includes articles, interviews, videos, podcasts, and breaking news on obesity research, treatment, and drug development.

Endocrinology

The HCPLive endocrinology page is a comprehensive resource for clinical news and insights on endocrine system conditions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for diabetes, hormonal disease, and more.

Indirect Analysis Suggests Greater Weight Loss With Oral Semaglutide vs Orforglipron

Ackerman offers a broad perspective on how psoriatic treatment is shifting, from oral IL-23 inhibitors to the emerging role of incretin therapy in psoriatic disease.

Dermatology

The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

AAD 2026: Owning Psoriatic Disease, With Lindsay Ackerman, MD

Experts examine CSU endotypes and their implications for treatment selection and preview the emerging therapeutic pipeline including barzolvolimab and novel mast cell–depleting strategies.

Disease Mechanisms, Emerging Therapies, and Reducing Corticosteroid Reliance in CSU 

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

The durability of both skin clearance and itch reduction extended up to 4 years of lebrikizumab use in this assessment of adults and adolescents with atopic dermatitis.

Atopic Dermatitis

Atopic Dermatitis condition center page, audiences can find a variety of coverage mediums for medical news and updates, including articles, video interviews, podcasts, and breaking news on dermatitis research, treatment, and drug development.

Lebrikizumab for Atopic Dermatitis Leads to 4 Years of Clearance, Itch Reduction

Podcasts

Late-breaking AAD 2026 trials spotlight PsA weight-loss combo, twice-yearly IL-13 dosing for atopic dermatitis, and a rapid oral TYK2 pill for psoriasis.

ABCs in Dermatology

Welcome to ABC’s in Dermatology, HCPLive’s newest dermatology podcast, hosted by a pair of the field’s leading minds in Lindsay Ackerman, MD, and Chris Bunick, MD, PhD.

Created by the same team behind The Medical Sisterhood and Skin of Color Savvy, ABCs in Dermatology is a monthly podcast designed to deliver candid conversations, clinical insight, and forward-looking perspectives from the voices shaping dermatology today.

podcasts page features a feed of medical news and interview podcast series, including DocTalk, Lungcast, Derm Discussions, and Heart Trials.

Latest News

Obicetrapib is Safe and Well-Tolerated in HeFH and ASCVD, With Stephen Nicholls, MD

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