White House Order Accelerates Psychedelic Research for Mental Illness, With Gus Alva, MD

A White House executive order issued April 18, 2026, directs federal agencies to accelerate psychedelic research for 

. Signed by President Donald Trump, the order outlines steps for prioritizing review of psychedelic compounds, facilitating access under the Right to Try framework, and supporting collaborative research efforts involving federal agencies, academic centers, and the private sector.

The policy calls on the Food and Drug Administration (FDA) to issue National Priority Vouchers for eligible psychedelic therapies with Breakthrough Therapy designation and instructs the Drug Enforcement Administration to help establish pathways for clinician and researcher access to Schedule I investigational agents. It also allocates ≥ $50 million through federal collaboration to support research programs and directs interagency data-sharing efforts, including coordination with the Department of Veterans Affairs, to expand clinical trial participation and real-world evidence generation. Additional provisions address expedited review and potential rescheduling of products containing Schedule I substances after successful phase 3 trials.

 spoke with Gus Alva, MD, psychiatrist and medical director of ATP Clinical Research, to assess the scientific rationale, emerging evidence, and clinical considerations surrounding psychedelic therapies. Alva highlighted proposed mechanisms centered on 5-HT2A receptor activation and downstream neuroplastic effects.

“What's novel about psychedelics is that…they're basically opening a window of heightened neuroplasticity,” Alva said. “The reason that this is important is that this might actually help out with creating new associations, new internal models, and thus the brain becoming more responsive to things that are salubrious to it.”

According to Alva, several hypotheses may help explain reported rapid onset and durability signals, including increases in dendritic spine density within the prefrontal cortex and modulation of the default mode network. He noted that these changes may reduce rigid self-referential processing associated with rumination in depressive disorders.

He also referenced the relaxed beliefs under the psychedelics (REBUS) model, which proposes that altered hierarchical processing may allow updating of maladaptive internal models. Despite these theoretical frameworks, Alva emphasized that unanswered questions remain and that cautious interpretation of early findings is warranted.

He described the current evidence base as promising but heterogeneous. Randomized trials of psilocybin for treatment-resistant depression (TRD), including studies in 

, have shown meaningful symptom reductions several weeks after dosing versus active comparators. Phase 3 trials of MDMA-assisted therapy for PTSD have also reported reductions in Clinician-Administered PTSD Scale scores with signals of durability.

However, he noted key limitations in interpretation, including difficulty maintaining blinding due to noticeable psychoactive effects and challenges separating drug effects from the structured psychotherapy embedded in treatment protocols. He also highlighted safety concerns, including potential cardiotoxicity associated with ibogaine and its evaluation in highly selected cohorts. He said these factors underscore the need for rigorous study designs, standardized safety monitoring, and longer-term follow-up.

Alva noted that the executive order’s emphasis on accelerating research and collaboration may expand trial participation and evidence generation. He added that clinicians should monitor evolving regulatory and clinical developments while maintaining focus on patient safety, infrastructure requirements, and therapist training as psychedelic therapies continue to be evaluated.

Relevant disclosures for Alva include Teva Pharmaceuticals, Otsuka America Pharmaceuticals, AbbVie Inc., Axsome Therapeutics, Janssen Pharmaceuticals, and more.

O’Neil G. Accelerating Medical Treatments for Serious Mental Illness. The White House. Published on April 18, 2026. Accessed April 20, 2026. 

https://www.whitehouse.gov/presidential-actions/2026/04/accelerating-medical-treatments-for-serious-mental-illness/

Kotkiewicz J. Fact Sheet: President Donald J. Trump is Accelerating Medical Treatments for Serious Mental Illness. The White House. Published April 18, 2026. 

https://www.whitehouse.gov/fact-sheets/2026/04/fact-sheet-president-donald-j-trump-is-accelerating-medical-treatments-for-serious-mental-illness/

Videos

Following an April 18 executive order, Gus Alva, MD, discusses psychedelic mechanisms, evidence, and clinical considerations for psychiatry.

News

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Psychiatry condition center page is a comprehensive resource for clinical news and insights on mental illnesses. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for depression, schizophrenia, bipolar disorder, anxiety, and more.

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Major Depressive Disorder condition center page, resources on the topics of medical news and expert insight into depression can be found. Content includes articles, interviews, videos, podcasts, and breaking news on MDD research, treatment, and drug development.

PTSD

Phillip Levy is an Assistant Professor of Emergency Medicine and Assistant Professor of Physiology at Wayne State University and the Assistant Vice President for Research at Wayne State University Department of Emergency Medicine.

Mobile Health Units Aim to Close Gaps in CKD Screening Access

Mobile health unit–based screening programs are emerging as a strategy to address gaps in 

 detection, particularly among populations without the access to routinely engage with traditional healthcare systems.

In Detroit, Michigan, investigators developed a community-based screening model aimed at reaching individuals at elevated risk for cardiometabolic disease who may not otherwise access preventive care. The population-wide screening program, found 11-13% had CKD ≥ stage 3, double the US population’s 6% reported national average.

“We provide care in a community that suffers disproportionately from early onset of things like heart disease and kidney disease and strokes secondary to poorly controlled risk factors like high blood pressure, diabetes, hyperlipidemia,” study investigator, Phillip Levy, an Assistant Professor of Emergency Medicine and Assistant Professor of Physiology at Wayne State University and the Assistant Vice President for Research at Wayne State University Department of Emergency Medicine, shared in an interview with 

 “There are high rates of smoking and obesity as well in the community, low rates of physical activity, socioeconomic challenges, and environmental exposures, all of which create outsized risk for the population we serve.”

Addressing Gaps in Preventive Care Access

The initiative reflects a broader shift in care delivery, informed in part by frontline experience treating advanced disease in acute care settings. Rather than continuing to intervene at late stages, the program was designed to move upstream and engage individuals earlier, particularly those who do not routinely seek care in traditional settings such as emergency departments or outpatient clinics.

To guide deployment, investigators developed geospatial analysis tools to identify high-risk communities using county-, ZIP code–, and census tract–level data, incorporating both clinical and social risk factors.

From Pandemic Response to Community-Based Screening

The model expanded during the COVID-19 pandemic, when mobile units were initially deployed for community-based testing. High levels of engagement, particularly willingness among community members to undergo blood-based testing, highlighted an opportunity to broaden screening beyond infectious disease.

In response, the program incorporated additional testing for hemoglobin A1c, kidney function, and lipid levels, using the point of community engagement to identify cardiometabolic risk earlier.

This evolution led to the development of a “portable population health” model, which integrates blood pressure screening using gold-standard triplicate protocols, laboratory testing, social determinants of health assessments, and coordinated linkage to follow-up care through community health workers.

Shifting Toward Population-Based Screening Models

Findings from the initiative support a broader reconsideration of how preventive screening is delivered, particularly in high-risk communities where clinic-based models may be insufficient.

“What we’re really striving toward… is the idea that prevention should be community-based, not office-based,” the investigator said. “Prevention screenings shouldn’t require a doctor to say that person needs to be screened for kidney disease, because we all need to be screened.”

The model emphasizes bringing screening directly to communities, reducing reliance on patient-initiated engagement with the healthcare system and addressing barriers such as transportation, time constraints, and competing life demands—even among insured populations.

Barriers to Scaling Community-Based Models

Levy noted that scaling this approach will require rethinking how care is delivered and reimbursed. Current healthcare models are largely structured around clinic-based services and physician-led encounters, which may not align with community-based, team-driven prevention strategies.

Expanding reimbursement pathways for services delivered in nontraditional settings, as well as supporting team-based care models, may be critical to broader adoption.

Editor’s Note: Levy report relevant disclosures with Cielo Foundation.

Brook RD, Korzeniewski SJ, Foster B, et al. Screening for Chronic Kidney Disease by Mobile Health Unit Outreach. JAMA Network Open. 2026;9(3):e262312. doi:

https://doi.org/10.1001/jamanetworkopen.2026.2312

This City’s CKD Stage ≥ 3 Incidence is Double The US National Average. HCPLive. Published 2026. Accessed April 20, 2026. 

https://www.hcplive.com/view/city-ckd-stage-3-incidence-double-us-national-average

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

Chronic Kidney Disease

Nancy Reau, MD, is Professor of Internal Medicine, Richard B. Capps Chair of Hepatology, Associate Director of Solid Organ Transplantation, and Section Chief of Hepatology at Rush University Medical Center.

Kimberly Brown, MD, is division chief of gastroenterology and hepatology and the Associate Medical Director of the Henry Ford Hospital Transplant Institute at Henry Ford Hospital. She is also a Professor of Medicine at Wayne State University

Meena Bansal, MD, is director of the MASLD/MASH (NAFLD/NASH) Center of Excellence at Mount Sinai and System Chief, Division of Liver Diseases for the Mount Sinai Health System.

Are We Screening Women for MASLD Often Enough?

metabolic dysfunction-associated steatotic liver disease (MASLD)

 continues to rise, clinicians are increasingly questioning whether current screening approaches fully capture risk in women. While existing guidelines identify key metabolic risk factors, concerns exist regarding their ability to adequately account for the physiologic changes women experience across the lifespan, particularly during transitions like menopause and pregnancy that significantly influence disease progression.

Current MASLD screening guidelines effectively identify at-risk populations but may not fully account for sex-specific risk across a woman’s lifespan.

The interval of monitoring is important, especially during high-risk transitions such as menopause, when fibrosis progression may accelerate.

Women with metabolic risk factors and early fibrosis may benefit from more frequent noninvasive assessments rather than standard multi-year follow-up.

PCOS screening and recognition should be part of risk assessment in younger women, given its link to insulin resistance and MASLD.

Greater engagement of OB/GYN providers is needed, as they often serve as primary care providers and are well-positioned to identify at-risk patients.

Patient empowerment is essential, including encouraging women to understand their risk, calculate FIB-4 scores, and advocate for further evaluation when steatosis is identified.

Liver Lineup: Updates and Unfiltered Insights

, Meena Bansal, MD, joins Nancy Reau, MD, and Kimberly Brown, MD, to examine a critical but often overlooked question in hepatology: should screening strategies for MASLD differ for women?

The discussion begins with Brown raising the possibility that while current guidelines effectively identify at-risk populations like individuals with diabetes, insulin resistance, or metabolic syndrome, they may not fully account for key transitions in a woman’s life. Bansal agrees that existing frameworks are generally sound but emphasizes that timing and frequency of screening are where clinicians may need to adapt their approach.

Rather than redefining who should be screened, Bansal highlights the importance of adjusting monitoring intervals during periods of increased risk, particularly around menopause. As hormonal changes accelerate metabolic dysfunction and fibrosis progression, she suggests that women in this transition, especially those with additional risk factors like diabetes or early fibrosis, may benefit from more frequent noninvasive assessments. Tools such as vibration-controlled transient elastography or serum-based biomarkers can help identify disease progression earlier, creating an opportunity for timely intervention.

Reau reinforces this point with clinical experience, noting that some patients previously considered low risk can return years later with advanced disease, often after significant metabolic changes and menopause, underscoring the need for greater vigilance during these inflection points.

Beyond hepatology, the conversation further expands to the role of multidisciplinary care. Bansal stresses the importance of engaging obstetricians and gynecologists, who often serve as primary care providers for many women. While awareness is growing, she notes that more education is needed to ensure these clinicians incorporate liver disease screening into routine care for at-risk patients. This includes using simple tools like the FIB-4 index as an initial step, followed by additional testing when indicated.

The group also highlights the importance of patient empowerment. Women are frequently told that “fatty liver” is benign, which may delay further evaluation. Encouraging patients to understand their risk factors, calculate their own FIB-4 scores, and advocate for follow-up care can play a meaningful role in earlier detection.

Editors’ note: Relevant disclosures for 

 include AbbVie, Gilead, Salix, Arbutus, and VIR. Relevant disclosures for 

 include Mallinckrodt Pharmaceuticals, Gilead, Salix, Intercept, Ipsen, and Madrigal. Relevant disclosures for 

 include Boeheringer-Ingelheim, Boston Pharma, Fibronostics, GSK, Madrigal, Merck, NOVO Nordisk, and The Kinetix Group.

DiStefano JK. NAFLD and NASH in Postmenopausal Women: Implications for Diagnosis and Treatment. Endocrinology. 2020;161(10):bqaa134. doi:10.1210/endocr/bqaa134

Sarkar M, Kushner T. Metabolic dysfunction-associated steatotic liver disease and pregnancy. J Clin Invest. 2025;135(10):e186426. Published 2025 May 15. doi:10.1172/JCI186426

Mass General Brigham. Patients Who Discontinued GLP-1s Had More Weight Gain, Complications During Pregnancy. November 24, 2025. Accessed April 20, 2026. 

https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/pregnancy-effects-from-discontinued-glp-1-use

Experts call for greater awareness, improved collaboration with OB/GYNs, and more proactive MASLD screening strategies for women.

Hepatology

MASH / MASLD

The HCPLive MASH & MASLD page is a comprehensive resource for clinical news and insights on metabolic dysfunction-associated steatotic liver disease and steatohepatitis. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for fatty liver disease, steatohepatitis, and more.

Screening Smarter: Identifying MASLD Risk in Women

Ashkan Shoamanesh, MD, is an associate professor of medicine and the Marta and Owen Boris Chair in Stroke Research and Care at McMaster University.

Asundexian Reduces Stroke Incidence Without Increasing Bleeding, With Ashkan Shoamanesh, MD

Asundexian, an investigational Factor XIa inhibitor, lowers the risk of stroke in patients who recently experienced non-cardioembolic 

 or a transient ischemic attack (TIA) without increasing bleeding, according to data from OCEANIC-STROKE.

Despite secondary prevention strategies, 5.1% of patients with ischemic stroke or TIA have a recurrent stroke within 1 year – after 5 years, 22% of patients who had survived the event are disabled or dead. Dual antiplatelet therapy incompletely reduces this risk, and long-term use is associated with higher risks of major hemorrhage. FXIa inhibition approaches the condition from a new angle, potentially circumventing these issues.

“Not only are we not seeing excess in major bleeding, but we also didn’t see excess in minor bleeding,” Ashkan Shoamanesh, MD, associate professor of medicine and Marta and Owen Boris Chair in Stroke Research and Care at McMaster University, told 

 in an exclusive interview. “Although minor bleeding is a less immediate clinical consequence regarding health, it certainly still is very significant, because it results in substantial psychological distress for patients and leads to non-compliance, which leads to less efficacy. It’s frankly historic to have a trial of this size and to have confidence in the results, and to see no excess risk with an antithrombotic versus placebo.”

OCEANIC-STROKE was a phase 3, double-blind, event-driven, randomized, placebo-controlled trial conducted at 702 centers across 37 countries. Patients were eligible if they were ≥18 years old with a non-cardioembolic ischemic stroke or high-risk TIA within 72 hours after the onset of symptoms and had a plan for treatment with dual or single antiplatelet therapy. Those with a history of atrial fibrillation or other conditions with an indication for anticoagulation, active nontrivial bleeding, or a qualifying stroke related to a procedure or other specific cause were excluded.

After enrollment, patients were randomly assigned in a 1:1 ratio to either asundexian 50 mg daily or matching placebo, on top of planned dual or single antiplatelet therapy. The trial’s primary outcome was the first occurrence of ischemic stroke, which was determined to have occurred if there was a new focal neurologic deficit or clinically meaningful worsening of an existing deficit persisting for ≥24 hours. The primary safety outcome was major bleeding, including fatal bleeding, symptomatic bleeding in a critical area or organ, and clinically overt bleeding resulting in a hemoglobin reduction of ≥2 g/dL.

A total of 12,327 patients were randomized, with 6162 assigned to the asundexian group and 6165 to placebo. A total of 45 patients withdrew consent, and 39 were lost to follow-up. The mean age of the final group of patients was 68 years. 11,677 patients presented with ischemic stroke, while the remainder had TIA. Median follow-up was 567 days (interquartile range [IQR], 377-729).

Ultimately, Shoamanesh and colleagues found that ischemic stroke incidence was substantially lower in the asundexian group than the placebo group (6.2% vs 8.4%; cause-specific HR, 0.74; 95% CI, 0.65-0.84; 

 <.001). The incidence of a composite of death from cardiovascular causes, myocardial infarction, or stroke was also lower in the asundexian arm. Major bleeding incidence was similar between both arms (1.9% and 1.7%, respectively; cause-specific HR, 1.1; 95% CI, 0.85-1.44). Adverse events occurred in 69.3% of the asundexian group and 70.1% in the placebo group – serious adverse events had an incidence of 19.2% and 19.5%, respectively.

The team concluded that treatment with asundexian substantially reduced the risk of ischemic stroke and major cardiovascular events compared with placebo, without increasing the risk of major bleeding in patients. Shoamanesh and colleagues believe that these data mark the beginning of a major shift in ischemic stroke treatment, and in cardiovascular disease overall, as a result of FXIa inhibition’s success.


“I think this is just the beginning of a large paradigm shift in our treatment of patients with cardiovascular disease,” Shoamanesh said. “Certainly, to date, there have been challenges with factor XI and other disease states. But I suspect the reason for that is that we just haven’t found the right recipe yet – either with higher doses of existing agents or with combination treatments, factor XI is going to be used more widely across the spectrum of cardiovascular disease and venous thromboembolic disease.”

Editors’ Note: Shoamanesh reports disclosures with the Heart and Stroke Foundation of Canada, the Marta and Owen Boris Foundation, Bayer AG, Daiichi Sankyo, AstraZeneca, Octapharma, Inc., and others.

McMaster University. New anti-clotting medication lowers risk of stroke without added bleeding. 

. April 15, 2026. Accessed April 20, 2026. 

https://www.eurekalert.org/news-releases/1123838

Sharma M, Dong Q, Hirano T, et al. Asundexian for secondary stroke prevention. 

Shoamanesh discusses the positive data from OCEANIC-STROKE, a phase 3 trial comparing the investigative FXIa inhibitor to placebo in patients with prior ischemic stroke.

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

Stroke

On the HCPLive stroke page, resources on the topics of medical news and expert insight into CVA can be found. Content includes articles, interviews, videos, podcasts, and breaking news on stroke medicine, and more.

Marie-José van Tol, PhD, from the University of Groningen.

Targeting Positive Affect May Prevent Depression Relapse, With Marie-José van Tol, PhD

New data suggest preventive cognitive therapy (PCT) may reduce relapse risk in recurrent 

by strengthening positive affect and modifying dysfunctional beliefs. In an interview with 

Marie-José van Tol, PhD, from the University of Groningen, described practical techniques clinicians can incorporate to enhance resilience during remission and potentially lower recurrence risk.

One strategy emphasized in PCT is “positive fantasizing,” a structured exercise designed to challenge rigid negative self-beliefs. Patients first identify a maladaptive belief, such as “I must do everything right to be worthwhile,” and then deliberately invert it.

“When you…think ‘I have to do everything right in order to be worthwhile,’ so making a mistake makes me [a] worthless person, we invited them to think…even if I do everything wrong, people will still find me fantastic,” van Tol said. “They were invited to think of their dream world, where they would live according to this fantasy belief, and that makes them experience that if they would think differently about themselves, they would feel different. They would have a different posture, they would say different things, they [might] make different jokes. So, it is [both] a positive effect enhancer, but it also invites people to understand the link between what they think and how they feel and experience that maybe there is some room, and their rigid negative belief might be shifted a bit towards a more helpful content.”

Van Tol suggested clinicians encourage patients to track events that went well, note moments of enjoyment, and “savor” small pleasurable experiences. Maintaining a positivity diary may help individuals recovering from depression re-engage with reward processing and rebuild comfort with positive emotions, which can diminish during depressive episodes. These practices aim to strengthen consummatory pleasure and support adaptive cognitive reappraisal

Although the findings are based on a relatively small and selective sample, van Tol noted that stability analyses, including bootstrapping approaches, supported the robustness of the observed associations. She emphasized that larger studies are needed to confirm generalizability and clarify causal relationships, particularly through more frequent longitudinal sampling of beliefs and affective states. Future research will also examine whether specific interventions, such as positive fantasizing, translate into sustained reductions in relapse risk.

“It's very important to realize that there is we focus often on the negative, effective domain in depression, but…there is [another] important domain,” she said. “I think that's good news, and I think it's very important to realize that even after a depression, we can help people build up resilience through offering certain therapy.”

Watch part 1 of the interview with van Tol here: 

Preventive Therapy Targeting Positive Affect May Reduce MDD Relapse, With Marie-José van Tol, PhD

Angeles-Valdez D, van Kleef R, van Valen E, Garza-Villarreal EA, Bockting C, van Tol MJ. The role of cognitive and affective changes in preventing depressive relapse: A network analysis approach to understanding the mechanisms of preventive cognitive therapy. 

Preventive cognitive therapy may reduce relapse in recurrent depression by strengthening positive affect and addressing anhedonia, van Tol explained.


Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

Articles

Phase 2b data from the 16-week extension of REZOLVE-AA suggest rezpegaldesleukin leads to continued hair regrowth through 52 weeks.

Alopecia

Dermatology

The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

REZOLVE-AA: 52-Week Data Highlight Positive Alopecia Areata Outcomes with Rezpegaldesleukin

Maria Hordinsky, MD, is an R.W. Goltz Professor of the Department of Dermatology at the University of Minnesota.

This interview highlights positive 12-month phase 3 results on clascoterone 5% topical solution for mild-to-moderate androgenetic alopecia, or hair loss.

Sustained 1-Year Efficacy Seen with Clascoterone for Androgenetic Alopecia, With Maria Hordinsky, MD

Victoria Johnson joined MJH Life Sciences in 2020 and has written for NeurologyLive, CGTLive, and is now an assistant managing editor for HCPLive and RheumatologyLive. She doesn’t have enough time for her numerous hobbies. You can reach her at vjohnson@mjhlifesciences.com.

Phase 3 MIRANDA found tozorakimab reduced COPD exacerbations in former smokers despite inhaled maintenance therapy.

COPD

COPD condition center page, resources on the topics of medical news and expert insight into chronic obstructive pulmonary disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on COPD research, treatment, and drug development.

Pulmonology

Infectious Disease condition center page is a comprehensive resource for clinical news and insights on respiratory health. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for asthma, COPD, interstitial lung disease, COVID-19, and more.

Phase 3 MIRANDA Trial Links Tozorakimab to Fewer COPD Exacerbations

Alex Hillenbrand is an assistant editor for 

. She earned her BA in English from Lafayette College in 2023 and went on to write for pop culture, entertainment, and sports media outlets before joining MJH Life Sciences in 2025. In her free time, Alex enjoys cooking, going on walks, and meeting new people. Contact her at mjhlifesciences.com.

Etavopivat reduced VOC events by 27% and improved hemoglobin response in the phase 3 HIBISCUS trial in sickle cell disease.

Hematology

Sickle Cell

Sickle Cell condition center page, resources on the topics of medical news and expert insight into sickle cell disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on sickle cell research, treatment, and drug development.

Phase 3 HIBISCUS: Etavopivat Cuts VOC Events, Improves Hemoglobin in SCD

Linda Stein Gold, MD, is a dermatologist at Henry Ford Health. 

In the final episode, "Integrating Comparative Evidence to Optimize Psoriasis Treatment Decisions," the panelists explore how the full body of available evidence, including comparative analyses, long term extension studies, real world data, and clinical experience, can be integrated into practical treatment decision making for plaque psoriasis.

Video Series

Integrating Comparative Evidence to Optimize Psoriasis Treatment Decisions

Dominic Sisti, PhD, is an associate professor in the Department of Medical Ethics & Health Policy and the director of the Scattergood Program for the Applied Ethics of Behavioral Health Care. Sisti is also the host of 

, our monthly multimedia series on medical ethics in modern healthcare. 

Aliza Narva, JD, discusses how clinical ethics consultation works in practice, from bedside dilemmas to mediation-based approaches and clinician support.

Podcasts

podcasts page features a feed of medical news and interview podcast series, including DocTalk, Lungcast, Derm Discussions, and Heart Trials.

Medical Ethics Unpacked

Medical Ethics Unpacked is a regular multimedia series hosted by Dominic Sisti, PhD, and Steve Levine, MD, spotlighting a spectrum of topics within the field of medical ethics. Throughout the year, hosts will sit down for an in-depth discussion on a specific ethical dilemma within modern healthcare, with some episodes also featuring a special guest. 

Check back throughout the year for discussions on a variety of topics, including data privacy in health apps, euthanasia and medical assistance in dying, reproductive rights and technologies, and more!

Medical Ethics Unpacked: Clinical Ethics Consultation in Practice

In this episode, "Evaluating IL-23 Inhibitors with Long-Term Data and Real-World Evidence," the expert dermatologists explore the distinct but complementary roles of long term extension studies and real world evidence in evaluating the durability and safety of biologic therapies for plaque psoriasis.

Evaluating IL-23 Inhibitors with Long-Term Data and Real-World Evidence

Roy Beck, MD, PhD, is the founder of the Jaeb Center for Health Research.

Beck discusses the recently presented results of INHALE-1, in which technosphere insulin failed to prove noninferiority to RAA but had no pulmonary effects.

Endocrinology

The HCPLive endocrinology page is a comprehensive resource for clinical news and insights on endocrine system conditions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for diabetes, hormonal disease, and more.

Type 1 Diabetes

Type 2 Diabetes

INHALE-1: Afrezza Safe but Not Superior to Rapid-Acting Analogue in Children, With Roy Beck, MD, PhD

Howard Trachtman, MD, is an adjunct clinical professor of pediatrics at the University of Michigan.

Listen to our conversation with Trachtman about sparsentan's recent FDA approval for FSGS.

Focal Segmental Glomerulosclerosis

The HCPLive focal segmental glomerulosclerosis page is a resource for medical news and expert insights on FSGS. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in FSGS, and more. 

FSGS Drug Development No Longer a ‘Graveyard’: What Comes After Sparsentan’s Approval

In a Q&A from AAD 2026, Elmariah highlights a variety of significant results highlighted in a poser session from the RELIEVE-PN study regarding dupilumab for prurigo nodularis.

Conference

 conference coverage page features articles, videos, and expert-led live coverage from major medical meetings throughout the year.

Latest News

White House Order Accelerates Psychedelic Research for Mental Illness, With Gus Alva, MD

Mobile Health Units Aim to Close Gaps in CKD Screening Access

Screening Smarter: Identifying MASLD Risk in Women

Asundexian Reduces Stroke Incidence Without Increasing Bleeding, With Ashkan Shoamanesh, MD

Targeting Positive Affect May Prevent Depression Relapse, With Marie-José van Tol, PhD