Pre-Symptomatic Detection of Crohn’s Disease Through Flagellin Antibodies, With Sun-Ho Lee, MD, PhD

Crohn’s disease is typically diagnosed only after patients develop overt gastrointestinal symptoms, yet mounting evidence suggests that the pathogenic process begins years earlier.

During this silent, preclinical phase, immune dysregulation and host-microbe interactions may already be driving disease evolution. Understanding these earliest events has become a key priority in inflammatory bowel disease research, with the goal of identifying biomarkers that can predict risk, inform surveillance, and ultimately enable strategies to delay or prevent disease onset.

A new study from the Lunenfeld-Tanenbaum Research Institute and Mount Sinai Hospital’s Center for Inflammatory Bowel Disease has identified a blood test that can predict Crohn’s disease years before symptoms appear by measuring a person’s immune response to flagellin.

“Up until this study, it was unclear, especially in healthy first relatives, what type of flagellin antigens were the drivers or triggered the immune response, and if these antibody responses were associated with other biomarkers that are related to onset of Crohn's,” study investigator Sun Ho Lee, MD, PhD, a gastroenterologist at Sinai Health Zane Cohen Centre for Digestive Diseases, told 

Seeking to address that gap and build upon previous research regarding immune response against gut microbes prior to Crohn’s diagnosis, he and a team of investigators followed 381 first-degree relatives of Crohn’s patients as part of the Genetic, Environmental, and Microbial (GEM) Project, a global cohort of > 5000 healthy first-degree relatives of people with Crohn’s disease. Among the population in the present study, 77 went on to develop the disease.

Using 2 complementary assays, the researchers evaluated antibody responses to 49 recombinant flagellin antigens. Results showed 19 of 49 IgG antimicrobial antibody responses were significantly associated with the risk of Crohn’s. These antibodies were reactive to the Lachnospiraceae family, particularly Roseburia-derived flagellins.

Additionally, 5 antibodies positively correlated with fecal calprotectin, whereas 3 positively correlated with lactulose-to-mannitol ratio. Of note, these IgG-seroreactive flagellins shared significant amino acid sequence homology, characterized by a conserved "hinge peptide" within D0-D1 domains of the amino-terminus. The cytometric bead array confirmed that elevated IgG seroreactivity to the hinge peptide is associated with future risk of Crohn’s, independent of both lactulose-to-mannitol ratio and fecal calprotectin.

Taken together, Lee emphasized that these findings help refine the understanding of preclinical Crohn’s disease and narrow the focus to specific microbial antigens and epitopes. He suggested that such highly specific immune signatures could form the basis for future biomarkers aimed at identifying individuals at risk of Crohn’s before clinical symptoms emerge.

Editors’ Note: Lee reports no relevant disclosures.

Wu RY, Xue M, Zhao Q, et al. Serum IgG Response to a Conserved Domain of Commensal Flagellins Predicts Future Risk of Crohn's Disease in First-degree Relatives. 

Lunenfeld-Tanenbaum Research Institute. A simple blood test can predict Crohn’s disease years before symptoms appear. EurekAlert! 

https://www.eurekalert.org/news-releases/1111855

Videos

Lee explains what is known about the preclinical phase of Crohn’s disease before symptoms appear and describes his study on the role immune dysregulation plays.

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Gianluca Florineth, MSc, from the Translational Research Center, University Hospital of Psychiatry and Psychotherapy at the University of Bern in Switzerland.

Preparation Improves Psychedelic Therapy for MDD, With Gianluca Florineth, MSc

Longer follow-up periods and therapy design choices may influence outcomes in psychedelic-assisted therapy (PAT) for 

, a recent meta-analysis found. The study highlights preparation therapy as a key factor in symptom reduction, while post-dosing integration sessions and total therapy duration showed no significant association with short-term outcomes.

spoke with investigator Gianluca Florineth, MSc, from the Translational Research Center at the University Hospital of Psychiatry and Psychotherapy, University of Bern, on this research. Despite many studies in the analysis having a high risk of bias due to ineffective blinding, Florineth has confidence in the strength of the association between preparation therapy and positive outcomes.

“It's a limitation that is very difficult to control in psychedelic research because the blinding is one of the most significant challenges that are faced in randomized trials using psychedelics, because the effects are so noticeable that participants can distinguish them if you assess it most of the time, over 95% probability,” Florineth said. “In my opinion, this doesn't really influence our findings that much because we look at this treatment as a combination of psychological and pharmacological therapy.”

He believes that the therapeutic processes occurring during preparations are not affected by this risk of bias. While these biases may influence the overall treatment effect, the relationship between therapeutic factors and symptom reduction is likely less affected.

Florineth’s team pooled data from 12 controlled trials, including 733 adults (49.8% female; mean age 42.1) receiving psilocybin- or LSD-assisted therapy. They examined associations between depressive symptom change and therapy-related variables, including preparation hours, integration hours, total therapy exposure, and overall treatment duration.

Each additional hour of preparation therapy correlated with greater depressive symptom reduction (

 =.04), whereas integration therapy hours (

=.86) were not significantly associated with short-term outcomes. Longer follow-up periods were linked to smaller effect sizes (

 =.003), consistent with the natural attenuation of therapeutic benefits over time. Most studies (75%) carried a high risk of bias, primarily due to ineffective blinding.

The findings suggest that preparation therapy may directly influence symptom reduction, while integration sessions and total therapy time likely serve other roles, such as consolidating therapeutic insights and maintaining gains, which are not captured by short-term depression measures. Factors such as therapeutic alliance, therapist experience, and patient readiness may critically shape outcomes, potentially outweighing the quantity of sessions.

From a trial design perspective, the study highlights the importance of reporting and evaluating psychological therapy components, including comparisons of high- versus low-support conditions and therapy intensity. For clinical implementation, the results underscore the need to consider psychedelics within a framework that integrates psychotherapy, regulatory guidance, therapist training, and minimum support standards to achieve and sustain clinical benefit.

“We hope that the role of psychological therapy will not just be dismissed,” Florineth said. “We see somewhat of a trend currently because of the FDA rejection of MDMA-assisted therapy, which was in some parts due to this unclear role of psychological therapy or this combination approach. Now, as a solution, some have started to prohibit the use of psychotherapy in their trial designs so that they can say it's a purely pharmacological intervention, but we think that this is a bit dangerous if you haven't really assessed the psychological therapy itself or its potential role or benefits. We hope that this gives at least some ideas that the role of psychological therapy should be explored further before we draw preliminary conclusions without really assessing it.”

Florineth GA, Klima I, Boeker AL, et al. Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2026;9(1):e2554843. Published 2026 Jan 2. 

Derman C. Preparation Before Psychedelics Tied to Better MDD, With Gianluca Florineth, MSc. HCPLive. Published on January 26, 2026. Accessed on January 30, 2026. 

https://www.hcplive.com/view/preparation-before-psychedelics-tied-better-mdd-gianluca-florineth-msc

Meta-analysis links longer preparation therapy and follow-up duration to depressive symptom change in psilocybin- and LSD-assisted treatment. 

Psychiatry

Psychiatry condition center page is a comprehensive resource for clinical news and insights on mental illnesses. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for depression, schizophrenia, bipolar disorder, anxiety, and more.

Major Depressive Disorder

Major Depressive Disorder condition center page, resources on the topics of medical news and expert insight into depression can be found. Content includes articles, interviews, videos, podcasts, and breaking news on MDD research, treatment, and drug development.

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

New phase 3 data on risankizumab suggest the treatment is both effective and safe over 52 weeks among pediatric patients with moderate-to-severe psoriasis.

 in a poster titled, ‘Efficacy and Safety of Risankizumab in Pediatric Patients With Psoriasis in the OptIMMize-1 Phase 3 Study: Results Through 52 Weeks.’ These data were authored by such investigators as Nina Magnolo, MD, from the University Hospital of Münster’s Department of Dermatology.

Magnolo et al’s analysis was aimed at evaluating long-term outcomes with risankizumab therapy in children and adolescents aged 6 years and older who lived with moderate-to-severe plaque psoriasis. These patients were also eligible for systemic drugs. In their background section, the investigators highlighted the chronic nature of psoriasis and its characteristic symptoms, including dryness, pruritus (itch), irritation, and pain, all of which can significantly disrupt daily functioning.

Despite the existence of advanced systemic treatments for adults with psoriasis, therapeutic options combining robust efficacy with long-term safety data remain more limited in younger populations, underscoring the need for additional pediatric-focused research on risankizumab. The drug itself is a humanized IgG1 monoclonal antibody designed to selectively target interleukin (IL)-23 by binding to its p19 subunit.

Prior results from the pediatric OptIMMize-1 study showed, following 16 weeks of risankizumab treatment, children and adolescents experienced improvements in their levels of pruritus, skin clearance, and quality of life, with tolerability shown to be comparable to adults.

 In this report, Magnolo and coauthors extend these findings by assessing efficacy and safety outcomes through 52 weeks of treatment.

In the phase 3 OptIMMize-1 study, investigators used a multicenter, four-part clinical trial design (NCT04435600), with Parts 1 and 3 evaluating the pharmacokinetics of risankizumab to help determine appropriate dosing. These portions are not included in this analysis. In Part 2, the investigative team enrolled adolescents in a randomized, efficacy assessor–blinded design.

The study’s initial 16-week active-controlled period involved randomization of the participants in a 2:1 ratio to be treated with risankizumab or ustekinumab. During the subsequent period included, subjects would either continue their treatment for up to 36 weeks or withdraw. At the 16-week mark, those originally treated with ustekinumab, as well as risankizumab nonresponders (defined by a static Physician’s Global Assessment score of 2 or higher), transitioned to risankizumab administered every 12 weeks through the 40-week mark.

Adolescents shown to respond to risankizumab at the 16-week mark, defined as those with an sPGA score of 0 or 1, were rerandomized to either continue risankizumab dosing every 12 weeks or discontinue the drug until disease flare, defined as an sPGA score of 3 or higher on or after Week 28. Those with flares after withdrawal entered a 16-week retreatment phase.

In Part 4, investigators used an open-label component including children between 6 - 12 years, all of whom received risankizumab for a total of 52 weeks. Across pediatric participants with moderate-to-severe psoriasis, Magnolo and colleagues identified a general continuation of clinical benefits at Week 16, or further improvements, through Week 52 with ongoing risankizumab use.

Such improvements included measures of skin clearance, reduction in pruritus, and quality of life shifts.

 Most adolescents who reported disease worsening following treatment withdrawal were able to recapture clinical responses following the 16-week retreatment period. Throughout the 52-week study’s duration, the medication was well-tolerated in both children and adolescents. Additionally, Magnolo et al pointed to its safety profile being consistent with findings previously reported in adult psoriasis populations.

“Together, these findings support the use of risankizumab to treat pediatric patients with moderate-to-severe psoriasis,” Magnolo and colleagues wrote.

Magnolo N, Lee L, Paller A, et al. Efficacy and Safety of Risankizumab in Pediatric Patients With Psoriasis in the OptIMMize-1 Phase 3 Study: Results Through 52 Weeks. Presented at: Maui Derm Hawaii 2026; January 25-29, 2026; Maui, Hawaii.

Pang Y, D'Cunha R, Winzenborg I, Veldman G, Pivorunas V, Wallace K. Risankizumab: Mechanism of action, clinical and translational science. Clin Transl Sci. 2024 Jan;17(1):e13706. doi: 10.1111/cts.13706. PMID: 38266061; PMCID: PMC10777435.

Articles

Phase 3 data indicate that risankizumab is effective and safe for pediatric patients with moderate-to-severe psoriasis over 52 weeks. The study involved children and adolescents aged 6 and older, highlighting the chronic nature of psoriasis and the need for pediatric-focused treatments. The OptIMMize-1 study showed improvements in pruritus, skin clearance, and quality of life, with a safety profile consistent with adult data. The study's design included a randomized, efficacy assessor–blinded approach, and the drug was well-tolerated, supporting its use in pediatric psoriasis treatment.

The Maui Derm Hawaii 2026 conference featured a poster presentation highlighting recent phase 3 findings on risankizumab in pediatric patients.

Plaque Psoriasis

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 conference coverage page features articles, videos, and expert-led live coverage from major medical meetings throughout the year.

OptIMMize-1: New Efficacy and Safety Data on Risankizumab in Pediatric Psoriasis

Nancy Reau, MD, is Professor of Internal Medicine, Richard B. Capps Chair of Hepatology, Associate Director of Solid Organ Transplantation, and Section Chief of Hepatology at Rush University Medical Center.

Identifying the Missing Link in Viral Hepatitis Elimination Efforts

In this segment of Liver Lineup, Nancy Reau, MD, and Kimberly Brown, MD, revisit the ongoing challenge of meeting 

 elimination targets, despite the availability of curative and highly effective therapies. Referencing recent observatory data compiled through collaborations between the World Health Organization and the US Centers for Disease Control and Prevention (CDC), the discussion underscores a persistent disconnect between what is possible scientifically and what is happening in real-world clinical practice.

Reau frames the issue bluntly, asserting that viral hepatitis remains a set of diseases that can be cured or well controlled, yet health systems are still falling short of elimination goals. While Brown acknowledges that her institution still lags behind in certain aspects, she highlights a notable success with eliminating viral hepatitis within a closed dialysis population by implementing a strategy built on universal testing.

Of note, instead of relying on referrals or action from outside clinicians, patients were screened systematically, and those who tested positive were proactively contacted and treated. According to Brown, this model demonstrated that elimination is achievable when identification and treatment are tightly integrated, but it also revealed that relying on individual providers to initiate screening can be a major barrier.

Both experts agree that patient identification remains the central obstacle. Screening for hepatitis B and C often falls to primary care, while hepatologists are left to manage treatment once patients are referred. Reau notes that even in systems with robust screening programs in high-risk settings, such as emergency departments and urgent care centers, linkage to care can be difficult, particularly for patients who are not already established within the health system.

Reau also expresses frustration with referrals for abnormal liver enzymes that lack basic hepatitis B and C testing. While acknowledging that viral hepatitis is not the most common cause of abnormal liver chemistries, she emphasizes that standard screening remains widely recommended and should not be overlooked. The absence of this testing, she argues, reflects missed opportunities for diagnosis rather than thoughtful exclusion.

Brown echoes that screening has improved at her institution, noting that patients she sees with elevated liver enzymes are now routinely tested for hepatitis B and C, even when the ultimate diagnosis is MASLD. Together, the discussion highlights that meaningful progress toward hepatitis elimination will depend less on new therapies and more on systematic screening, proactive outreach, and closing persistent gaps in care delivery.

Editors’ note: Relevant Disclosures for Reau include AbbVie, Gilead, Salix, Arbutus, and VIR. Relevant disclosures for Brown include Mallinckrodt Pharmaceuticals, Gilead, Salix, Intercept, Ipsen, and Madrigal.

Manning J, Ward J, Hiebert-Suwondo L. Global Progress toward the Elimination of Hepatitis B: Country-Level Provisional Achievements of WHO Targets for Prevention, Care, and Reductions in Mortality. Presented at the American Association for the Study of Liver Diseases (AASLD) The Liver Meeting 2025. Washington, DC. November 7-11, 2025.

Ching Z, Hiebert-Suwondo L, Ward J. Global Progress Toward Hepatitis C Elimination: Monitoring Achievements of WHO Goals and Targets for Hepatitis C Prevention and Care. Presented at the American Association for the Study of Liver Diseases (AASLD) The Liver Meeting 2025. Washington, DC. November 7-11, 2025.

In this segment, Nancy Reau, MD, and Kimberly Brown, MD, discuss ongoing challenges with viral hepatitis elimination efforts and clinical shortcomings in screening.

Hepatology

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Hiroshi Iwamoto, MD, PhD, from Hiroshima University

Depressive symptoms are common in patients with asthma and are consistently linked to poorer disease control and greater severity. However, emerging evidence suggests that asthma-related depression may be biologically distinct from 

, with elevated levels of brain-derived neurotrophic factor (BDNF) in patients with 

In this multicenter observational study, investigators analyzed data from 140 adults with asthma enrolled in the Physical Activity in Bronchial Asthma (PACTAS) study. Serum BDNF levels were measured using an enzyme-linked immunosorbent assay, while depressive and anxiety symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Daily physical activity was objectively quantified using a triaxial accelerometer.

Contrary to patterns seen in MDD, where reduced BDNF is a hallmark, serum BDNF levels were positively associated with depressive symptom severity in patients with asthma (

<.001). Patients with clinically relevant depressive symptoms (HADS-D ≥8) had significantly greater BDNF levels than those without.

Elevated BDNF was also independently associated with greater asthma severity, as reflected by higher treatment step, and poorer asthma control. Exploratory mediation analyses suggested that BDNF may partially mediate the relationship between asthma severity and depressive symptoms. These findings suggest that depressive symptoms in asthma may reflect disease-related inflammatory or stress pathways rather than the neurotrophic deficits characteristic of primary depression.

conducted a Q&A with investigator Hiroshi Iwamoto, MD, PhD, from Hiroshima University in Japan, on clinical implications of these findings and how they may inform a more integrated approach to managing asthma and mental health.

How should clinicians rethink depressive symptoms in asthma, given that higher—not lower—BDNF levels were associated with worse mood?

 Clinicians should consider that depressive symptoms in asthma may not share the same biological background as primary major depressive disorder. In asthma, elevated BDNF may reflect physiological stress or disease burden.

What does the association between elevated BDNF and asthma severity reveal about the brain–lung axis in chronic airway disease?

 Our study does not provide direct evidence of a brain–lung axis. Rather, it shows an association between asthma severity, circulating BDNF levels, and depressive symptoms, which may warrant further mechanistic investigation.

Do your findings suggest that depressive symptoms in asthma are more closely linked to disease burden than to primary major depressive disorder?

 Yes. Our results indicate that depressive symptoms in asthma appear to be more closely associated with asthma severity and disease burden than with the biological profile typically seen in primary major depressive disorder.

How should clinicians address poor asthma control and physical inactivity when managing depressive symptoms in patients with asthma?

 Management may benefit from optimizing asthma control and addressing physical inactivity, alongside screening and support for depressive symptoms, rather than focusing solely on psychiatric treatment.

Given that antidepressants increase BDNF in major depressive disorder, how should clinicians interpret elevated BDNF levels in patients with asthma who have depressive symptoms?

 In asthma, elevated BDNF should not automatically be interpreted as a marker of antidepressant response. It may instead reflect asthma-related inflammation or stress, although patients with comorbid major depressive disorder may still benefit from antidepressant therapy.

What are the limitations of applying traditional depression biomarkers or frameworks to patients with asthma based on your data?

 Traditional biomarkers and frameworks derived from major depressive disorder may not fully capture the mechanisms of asthma-related depressive symptoms.

Is there a realistic future role for serum BDNF as a clinical biomarker in asthma, or is its value primarily mechanistic at this stage?

 At present, the value of serum BDNF is primarily mechanistic. Its potential role as a clinical biomarker will require validation in longitudinal and interventional studies.

Based on your findings, what should an integrated, day-to-day clinical approach to asthma-related depressive symptoms look like today?

 An integrated approach should address asthma control, physical activity, and mental health simultaneously, with collaboration between respiratory and mental health care when needed.

What further research is needed on this topic?

 Further longitudinal and interventional studies are needed to clarify the temporal and causal relationships between asthma severity, BDNF levels, and depressive symptoms, and to determine whether BDNF can help stratify depressive symptoms or guide personalized management in asthma.

Kawamoto K, Iwamoto H, Hirano T, et al. Brain-Derived Neurotrophic Factor Levels Are Associated With Depressive Symptoms in Patients With Asthma. 

. Published online November 11, 2025. doi:10.1016/j.jaip.2025.11.001

Depressive symptoms in asthma patients are linked to elevated brain-derived neurotrophic factor (BDNF) levels, contrasting with major depressive disorder (MDD) where reduced BDNF is typical. This suggests asthma-related depression may stem from disease-related inflammatory or stress pathways rather than neurotrophic deficits. Elevated BDNF correlates with greater asthma severity and poorer control. Clinicians should consider integrated management addressing asthma control, physical activity, and mental health. Further research is needed to explore BDNF's potential as a biomarker and its role in personalized asthma management.

New data suggest asthma-related depression may be biologically distinct from MDD, with greater serum BDNF tied to worse disease severity and lower physical activity.

Asthma

The HCPLive asthma page is a comprehensive resource for clinical news and insights on asthmatic disease. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for allergic and severe asthma, and more.

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Infectious Disease condition center page is a comprehensive resource for clinical news and insights on respiratory health. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for asthma, COPD, interstitial lung disease, COVID-19, and more.

Elevated BDNF Linked to Depressive Symptoms in Patients with Asthma, With Hiroshi Iwamoto, MD, PhD

Ryan Livingston joined the MJH Life Sciences team in March of 2025, shortly after graduating from TCNJ with a bachelor’s degree in English. He enjoys creative writing, reading, and scuba diving. He can be reached at rlivingston@mjhlifesciences.com.

Since 1990, the prevalence of individuals with a BMI ≥30 has increased dramatically, and without significant intervention, will continue to do so.

Endocrinology

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Obesity Management

Obesity Management condition center page, resources on the topics of medical news and expert insight into clinical weight management can be found. Content includes articles, interviews, videos, podcasts, and breaking news on obesity research, treatment, and drug development.

Obesity Prevalence in US Increasing Drastically, Expected to Continue into 2035

Holly Kramer, MD, is a nephrologist at Loyola University Medical Center and the editor in chief of 

Clinicians can provide dietitian intervention to reduce the risk of obesity, which is independently associated with CKD.  


Utilizing Diet to Prevent Obesity, Preserve Kidney Function, With Holly Kramer, MD

Sina Kianersi, PhD, is a research fellow in medicine at Brigham and Women’s Hospital.

Kianersi discusses how, although evening chronotype can be associated indirectly with increased CVD risk, this can be mediated via Life’s Essential 8 scores.

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

Heart Failure

The HCPLive heart failure page is a resource for medical news and expert insights on HF. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for heart disease, reduced and preserved ejection fraction, and more.

Stroke

On the HCPLive stroke page, resources on the topics of medical news and expert insight into CVA can be found. Content includes articles, interviews, videos, podcasts, and breaking news on stroke medicine, and more.

Staying Up Late Associated With CVD Risk Through Worse LE8 Scores, With Sina Kianersi, PhD

At the Maui Derm Hawaii 2026 conference, Lawrence Eichenfield, MD, spoke about highlights from his talk, ‘Atopic Dermatitis and Pruritus: Current Concepts and Therapeutics for 2026.’

Atopic Dermatitis

Atopic Dermatitis condition center page, audiences can find a variety of coverage mediums for medical news and updates, including articles, video interviews, podcasts, and breaking news on dermatitis research, treatment, and drug development.

Highlighting Therapeutic Updates for Atopic Dermatitis and Itch, With Lawrence Eichenfield, MD

The safety and efficacy of risankizumab versus deucravacitinib were evaluated among patients with moderate psoriasis and no prior biologic use.

IMMpactful: Risankizumab Shows Greater Clinical Response to Deucravacitinib in Psoriasis

Abigail Brooks is an assistant managing editor for 

She joined MJH Life Sciences in August 2023 shortly after graduating from Monmouth University where she earned her BA in Communication with a concentration in Public Relations/Journalism and later an MA in Interactive Digital Media. She enjoys traveling, running, and reading books. She can be reached at abrooks@mjhlifesciences.com.

The US Centers for Medicare & Medicaid Services selected 15 high-cost drugs for the third cycle of the Medicare Drug Price Negotiation Program, including the first-ever Part B drugs.

Internal Medicine

Internal Medicine condition center page, resources on the topics of medical news and expert insight into internal medicine can be found. Content includes articles, interviews, videos, podcasts, and breaking news on internal medicine research, treatment, and drug development.

CMS Selects 15 Drugs for Third Cycle of Medicare Drug Price Negotiation Program

David Bharucha, MD, PhD, is the chief medical officer of Milestone Pharmaceuticals.

Milestone Therapeutics’ novel, self-administered medication for paroxysmal supraventricular tachycardia has released alongside a patient support program.

Arrhythmia

Cardamyst (Etripamil) Nasal Spray Now Commercially Available for Adults with PSVT

Robert Negrin, MD, is president of the American Society of Hematology and a professor of medicine at Stanford University. 

Robert Negrin discusses ASH initiatives to sustain hematology research, early-career careers, and global clinical programs.


Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

ASH Addresses Funding, Career Development Gaps in Hematology, With President Robert Negrin, MD

Nancy Reau, MD, and Kimberly Brown, MD, discuss the challenges of accurately assessing and addressing alcohol use in patients with MASLD.

MASH / MASLD

The HCPLive MASH & MASLD page is a comprehensive resource for clinical news and insights on metabolic dysfunction-associated steatotic liver disease and steatohepatitis. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for fatty liver disease, steatohepatitis, and more.

Latest News

Pre-Symptomatic Detection of Crohn’s Disease Through Flagellin Antibodies, With Sun-Ho Lee, MD, PhD

Preparation Improves Psychedelic Therapy for MDD, With Gianluca Florineth, MSc

OptIMMize-1: New Efficacy and Safety Data on Risankizumab in Pediatric Psoriasis

Identifying the Missing Link in Viral Hepatitis Elimination Efforts

Elevated BDNF Linked to Depressive Symptoms in Patients with Asthma, With Hiroshi Iwamoto, MD, PhD