Can CAR-T Cell Therapy Transform Lupus Nephritis Care? With Brad Rovin, MD

The treatment of lupus nephritis has long been challenged by profound disease heterogeneity and incomplete responses to standard immunosuppressive therapies. Despite recent advances and newly approved agents, many patients still fail to achieve complete remission. Against this backdrop, the emergence of CAR-T cell therapy represents a potentially transformative step, rooted in the field’s broader shift toward precision medicine and deeper immune modulation.

 at the World Congress of Nephrology (WCN) Conference in Yokohama, Japan, Brad Rovin, MD, explains how the field has historically relied on broadly acting immunosuppressive approaches, such as high-dose cyclophosphamide or mycophenolate, which “treat everything” but fail to account for the biological variability across patients. He says that this one-size-fits-all strategy is increasingly being replaced by efforts to tailor therapy more precisely, particularly as it has become clear that more than half of patients do not achieve complete clinical remission with existing options.

“I think with the idea of using something like a CAR-T cell, we borrow a lot of things from oncology, there's no question about it,” he said. “The idea was, could we affect the immune system in a way that renders it less likely to attack in an autoimmune way for some prolonged period of time? I'm hesitant to use the word cure, because I don't know that we've established cure yet. I think the CAR-T data show that we can, in some patients, achieve a prolonged drug free response. Whether that is a cure in some people, we'll see.”

A key differentiator, Rovin explains, lies in the depth and breadth of B-cell targeting. Unlike conventional anti-CD20 therapies like obinutuzumab (Gazyva), which target a narrower subset of B cells, CAR-T therapies directed at CD19 affect a broader range of the B-cell lineage, including antibody-producing populations. He highlights that CAR-T therapy also appears to induce more complete depletion within lymphoid tissues, including germinal centers, which may be critical for sustained disease control and may go beyond what is achieved with current therapies.

He describes the most striking findings to date as reports of sustained clinical remission lasting up to 4 years without ongoing immunosuppression. However, he emphasizes that these results are not universal, and the therapy carries significant risks, including profound immunosuppression and potential toxicities.

Looking ahead, Rovin stresses the importance of careful patient selection, transparent communication, and continued clinical investigation. While CAR-T therapy may represent a paradigm shift in lupus care, defining its long-term role and balancing its promise with its risks will be essential as the field moves forward.

“I think now it's up to us to continue the investigations, which are ongoing, and now trials are enrolling pretty well and and try to sort these issues out, but like any new therapy, there's going to be bumps, and I think that this is important to think about when we talk to our patients and families about this,” he said.

Editors’ Note: Relevant disclosures for Rovin include Biogen, GSK, Genentech/Roche, BMS, Travere, Alexion, Novartis, AstraZeneca, Otsuka, Calliditis, and others.

Brooks A. FDA Approves Obinutuzumab (Gazyva) for Lupus Nephritis. RheumatologyLive. October 20, 2025. Accessed March 29, 2026. 

https://www.rheum-live.com/view/fda-approves-obinutuzumab-gazyva-for-lupus-nephritis

Musa R, Rout P, Qurie A. Lupus Nephritis. StatPearls. January 16, 2025. Accessed March 29, 2026. 

https://www.ncbi.nlm.nih.gov/books/NBK499817/

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CAR-T therapy shows potential for deep, durable remission in lupus nephritis, but questions remain on safety, durability, and patient selection.

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Patrick Campbell is the editorial director of HCPLive. Patrick has spent years spearheading coverage surrounding cardiometabolic health and rheumatic disease for MJH Life Sciences. Before joining MJH Life Sciences in 2019, he spent time as a beat reporter and/or multimedia specialist with the Pocono Record, Star News Group, and NJ Advance Media. He is the executive producer for multiple HCPLive podcasts, including Diabetes Dialogue, Don't Miss a Beat, Kidney Compass, Medical Ethics Unpacked, The Medical Sisterhood, and Skin of Color Savvy. 


Follow him on Twitter @RealPatCampbell or reach him via email at PCampbell@mjhlifesciences.com.

Nicholas Marston, MD
Credit: American College of Cardiology

An analysis of the VESALIUS-CV trial is extending the evidence base for 

 beyond established secondary prevention populations.

A prespecified subgroup analysis of the VESALIUS-CV trial, results suggest the PCSK9 inhibitor evolocumab significantly reduced the risk of a first major cardiovascular event in high-risk primary prevention patients with diabetes and no known significant atherosclerosis.

“I think this study changes the paradigm,” said Nicholas Marston, MD, MPH, a cardiologist and assistant professor of medicine at Brigham and Women’s Hospital and Harvard Medical School, who presented the data at the 

American College of Cardiology's Annual Scientific Session (ACC.26)

N=3655; all had diabetes, no known significant atherosclerosis

Median achieved LDL-C at 48 weeks: 52 mg/dL (evolocumab) vs 111 mg/dL (placebo)

VESALIUS-CV Subgroup Design and Population

VESALIUS-CV was a randomized, double-blind, placebo-controlled trial of evolocumab conducted across 774 sites in 33 countries, enrolling 12,257 patients without prior myocardial infarction or stroke who had qualifying atherosclerosis or high-risk diabetes and an LDL-C level of 90 mg/dL or greater.

This prespecified subgroup analysis examined the 3655 patients without known significant atherosclerosis, defined as the absence of prior arterial revascularization, arterial stenosis of 50% or greater, or a coronary artery calcium score of 100 Agatston units or greater. All patients in this subgroup had diabetes and the median follow-up was 4.8 years.

Patients were randomized 1:1 to subcutaneous evolocumab 140 mg every 2 weeks or matching placebo added to optimally tolerated statin therapy. The median age was 65 years, 57% were female, 89% were receiving lipid-lowering therapy at baseline, and 64% were on high-intensity statin therapy. Median baseline LDL-C was 132 mg/dL.

The dual primary endpoints were 3-point MACE, which was defined as coronary heart disease death, myocardial infarction, or ischemic stroke, and 4-point MACE, which also included ischemia-driven arterial revascularization.

31% Reduction in MACE Across Both Primary Endpoints

At the 5-year Kaplan-Meier estimate, evolocumab reduced the 3-point MACE rate from 7.1% to 5.0% (hazard ratio [HR], 0.69; 95% CI, 0.52-0.91; 

= .009), representing a between-group difference of 2.1%. The 4-point MACE rate was reduced from 10.5% to 7.6% (HR, 0.69; 95% CI, 0.55-0.86; 

= .001), a between-group difference of 2.9%.

Evolocumab also reduced the risk of cardiovascular death (HR, 0.68; 95% CI, 0.46-0.99) and all-cause mortality (HR, 0.76; 95% CI, 0.61-0.95), though the investigators noted that due to the prespecified hierarchical testing order, mortality reductions should be considered exploratory. Among the lipid substudy participants, median LDL-C at 48 weeks was 52 mg/dL in the evolocumab group versus 111 mg/dL in the placebo group.

An additional analysis demonstrated the treatment benefit became more apparent after year 1, with 41% and 39% reductions in 3-point and 4-point MACE risk in subsequent years, consistent with an expected lag in clinical benefit in patients without pre-existing plaque.

The investigators noted current US guidelines assign only a class 2b recommendation for adding a nonstatin agent in high-risk primary prevention patients with diabetes whose LDL-C remains above 70 mg/dL, resulting in infrequent intensification of therapy in this population.

“In current practice, PCSK9 inhibitors are largely reserved for patients who have had a prior heart attack or stroke,” Marston added. “But here we see a benefit of using evolocumab not only to treat patients without a history of heart attack or stroke, but without known significant atherosclerosis. It’s a message to physicians and patients that we don’t have to wait until someone has atherosclerosis to treat them intensively. We can—and should—be much more proactive.”

Investigators called attention to several limitations warranting consideration. These included the analysis being a prespecified subgroup, imaging to detect atherosclerosis was not performed in all patients, and the population was predominantly White and entirely composed of high-risk diabetic patients.

Marston NA, Bohula EA, Bhatia AK, et al. Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes: Results From the VESALIUS-CV Trial. JAMA. Published online March 28, 2026. doi:

American College of Cardiology. Evolocumab Cuts Cardiac Risk in Patients Without Known Atherosclerosis and With Diabetes - American College of Cardiology. American College of Cardiology. Published March 28, 2026. Accessed March 28, 2026. 

https://www.acc.org/About-ACC/Press-Releases/2026/03/28/15/33/Evolocumab-Cuts-Cardiac-Risk-in-Patients-Without-Known-Atherosclerosis-and-With-Diabetes 

Lloyd-Jones DM, Morris PB, Ballantyne CM, et al. 2022 ACC expert consensus decision pathway on the role of nonstatin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk. 

. 2022;80(14):1366-1418. doi:10.1016/j.jacc.2022.07.006

Articles

A subgroup analysis of VESALIUS-CV suggests evolocumab could have a role in prevention of primary events in some high-risk patients.

Dyslipidemia

Atherosclerotic Cardiovascular Disease

Type 2 Diabetes

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

VESALIUS-CV: Evolocumab Cuts First MACE Risk in Diabetes Without Atherosclerosis

is shedding additional light on the effects of tonlamarsen on 

Journal of the American College of Cardiology

, results demonstrate the investigational antisense oligonucleotide produced significant, dose-dependent reductions in plasma angiotensinogen among adults with uncontrolled hypertension on multiple antihypertensive medications, but failed to demonstrate additional blood pressure lowering with continued monthly dosing compared with a single dose followed by placebo.

“Because the drug was dosed monthly, we predicted that angiotensinogen would be fully back to its baseline levels by 20 weeks, but we found tonlamarsen’s effect was much longer acting than we would have predicted. The continued decrease in blood pressure after a single dose surprised us,” said Luke Laffin, MD, a cardiologist at Cleveland Clinic and the study’s lead author. “We also did not anticipate the finding that the percentage of angiotensinogen reduction didn’t necessarily correspond to blood pressure lowering 20 weeks out. This trial raises more questions than it gives answers at this point, but it gives us data that’s unique.”

Co-primary endpoints: percent change in plasma angiotensinogen and change in office systolic BP at week 20

Angiotensinogen decreased 67.2% with monthly dosing vs 23.0% with single dose (

<.0001); systolic BP change was -6.7 mm Hg in both arms (

Serious adverse events occurred in 5% of monthly-dosing arm vs 2.1% of single-dose arm; injection site reactions more frequent with ongoing dosing

KARDINAL was a multicenter, prospective, double-blind, placebo-controlled phase 2 trial conducted at 39 US sites between February and August 2025. The trial enrolled adults aged 18 years or older with office systolic blood pressure between 135 and 170 mmHg who were receiving stable doses of 2 to 5 antihypertensive agents. Key exclusion criteria included secondary hypertension, estimated glomerular filtration rate below 30 mL/min/1.73 m², and serum potassium greater than 5.1 mmol/L.

Following a 4-week placebo lead-in, all eligible participants received a single subcutaneous 90 mg dose of tonlamarsen during an active run-in period. Participants were then randomized 1:1 to either 4 additional monthly doses of tonlamarsen or matching placebo for 16 weeks. 

Of 519 patients screened, 206 received the active run-in dose and 198 were ultimately randomized: 100 to ongoing monthly tonlamarsen and 98 to single-dose tonlamarsen followed by placebo.

The overall study cohort had a mean age of 61 years, 49% were Black, 41% were female, and 82% were receiving an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) at baseline. The mean baseline office systolic blood pressure of the cohort was approximately 147 mmHg.

The coprimary endpoints were the between-group differences in percent change from baseline in plasma angiotensinogen and change in office systolic blood pressure at week 20.

AGT Suppression Diverged, Blood Pressure Did Not

At week 20, participants receiving monthly tonlamarsen demonstrated a least-squares (LS) mean reduction in plasma angiotensinogen of 67.2% (95% CI, -71.9 to -62.4) compared with 23.0% (95% CI, -27.8 to -18.2) among those receiving a single dose followed by placebo, a statistically significant between-group difference of -44.1% (97.5% CI, -51.9 to -36.4; 

However, the change in office systolic blood pressure was identical between arms at week 20. Specifically, a reduction of -6.7 mmHg was observed in both groups, yielding a between-group difference of -0.1 mmHg (95% CI, -4.5 to 4.4; 

= .97). No significant between-group differences were observed in home systolic blood pressure, office diastolic blood pressure, or proportion of participants achieving a systolic blood pressure below 130 mmHg.

The investigators noted the 23% residual suppression of angiotensinogen observed at week 20 in participants who received only 1 dose was unexpected given tonlamarsen's elimination half-life of 2 to 4 weeks. The persistence of angiotensinogen suppression in the placebo arm may have introduced a carryover effect confounded the blood pressure comparison between arms.

“One possibility, which we think is most likely, is that tonlamarsen lowers blood pressure by about 6-7 mmHg, and this is maintained even as angiotensinogen levels rise,” Laffin added. “Another possibility is that residual angiotensin suppression among placebo participants resulted in greater blood pressure reduction than expected. It’s also possible that decreasing angiotensin with tonlamarsen doesn’t reduce blood pressure, although we think that’s probably not likely based on the fact that blood pressure dropped during the drug run-in period.”

KARDINAL Safety Outcomes and Trial Limitations

Serious adverse events were infrequent and occurred in 2.1% of single-dose participants and 5.0% of those receiving ongoing tonlamarsen. A single death occurred in the monthly dosing arm and was assessed as unrelated to study drug by the site investigator. Injection site reactions were more common with multiple doses (19% vs 3%).

Trial investigators called attention to multiple limitations, including its active run-in design, which precluded a clean placebo comparator for assessing the true magnitude of blood pressure reduction. Additional limitations highlighted by investigators included its restriction to US sites, which may limit generalizability, and its modest sample size and short duration, which were insufficient to evaluate cardiovascular outcomes. Investigators suggested future trials should include a true placebo group without a tonlamarsen run-in.

Laffin LJ, Wang Q, Sarraju A, et al. Efficacy of Tonlamarsen in Patients with Uncontrolled Hypertension: The KARDINAL Phase 2 Randomized Clinical Trial. 

American College of Cardiology. Investigational Drug Delivers Mixed Results for Uncontrolled Blood Pressure - American College of Cardiology. American College of Cardiology. Published March 28, 2026. Accessed March 28, 2026. 

https://www.acc.org/About-ACC/Press-Releases/2026/03/28/18/33/Investigational-Drug-Delivers-Mixed-Results-for-Uncontrolled-Blood-Pressure

New data from the KARDINAL trial at ACC.26 provides insight, but raises questions regarding tonlamarsen and hypertension. 

Hypertension

The HCPLive hypertension page is a resource for medical news and expert insights on high blood pressure. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for hypertension, and more.

Monthly Tonlamarsen Reduces Angiotensinogen, But No Significant Difference in Blood Pressure

Amy Sarma, MD, is the Cathy E. Minehan Endowed Chair in Cardiology and co-director of the Corrigan Women’s Heart Health Program and Cardiovascular Disease and Pregnancy Programs at the Massachusetts General Hospital.

Combatting Cardiovascular Risk in Postpartum and Menopausal Women

Women’s cardiovascular disease has long been a comparatively understudied sphere of cardiology as a whole – but in recent years, this sphere is positioned for a major reversal, particularly in such tumultuous times as postpartum and menopause.

American College of Cardiology (ACC) Scientific Sessions 2026

, the omnipresent issue of women’s access to cardiovascular care was again highlighted. In a series of presentations chaired in part by Amy Sarma, MD, co-director of the Corrigan Women’s Heart Health Program and Cardiovascular Disease and Pregnancy Programs at the Massachusetts General Hospital, as well as the Cathy E. Minehan Endowed Chair in Cardiology, the focus fell on 2 periods of women’s lives in particular, both of which are inherently transitory – the postpartum period and menopause.

“We’ve increasingly discovered that women are not just little men – we have unique sex-specific risk factors and differences in the types of cardiovascular conditions for which there is a greater susceptibility,” Sarma told 

 in an exclusive interview. “It’s very exciting that the ACC is increasingly covering topics highlighting these sex-specific differences – there’s a lot of excitement in this space that there hasn’t necessarily been in the past.”

A 2024 Scientific Statement from the American Heart Association (AHA) highlighted the risk of cardiovascular disease after adverse pregnancy outcomes, including 

, fetal growth restriction, and placental abruption. These conditions can directly influence the lifetime risk of 

atherosclerotic cardiovascular disease (ASCVD)

However, despite these associations, at the time of the statement’s writing, guidelines lacked recommendations to reduce cardiovascular disease risk and optimize health after adverse pregnancy outcomes. The fourth trimester, defined as the 12 weeks after delivery, is widely understood to be an optimal time for cardiovascular care to reduce maternal morbidity and improve transitions for postpartum patients.

Unlike the postpartum period, menopause is a physiologic event occurring in all women at roughly 52 years of age. Given the current life expectancy among women of 81 years, this results in roughly 1/3 of a woman’s life spent in menopause. Although women have a comparatively lower prevalence of cardiovascular disease than men, these rates exhibit a substantial increase after menopause, typically manifesting around 10 years after.

A 2021 review attempts to qualify this increase, attributing it largely to the similarly increased prevalence of adverse risk factors that often accompany menopause. These include insulin resistance, 

, fat redistribution, and other critical factors, the increase of all of which is thought to begin during the menopausal transition period.

Sarma spoke to the next steps cardiology should take to provide for women during these transitional periods of their lives. She highlighted more intensive and frequent screening for common cardiovascular risk factors, as well as increasing access to critical care among female patients.

“We need to think about being innovative in the way that we deliver care right now, particularly if we take, for example, the postpartum period,” Sarma said. “This is a period of time where we know that there are dynamic changes in the hemodynamics of patients, occurring on even a daily basis. While we routinely assess and reassess women during their pregnancy, their connection to care really falls off in that postpartum period where they remain at higher risk, but don’t have that same access to care.”

Editors’ Note: Sarma reports disclosures with King Pharmaceuticals, now part of Pfizer.

Lewey J, Beckie TM, Brown HL, et al. Opportunities in the Postpartum Period to Reduce Cardiovascular Disease Risk After Adverse Pregnancy Outcomes: A Scientific Statement From the American Heart Association. Circulation. 2024;149(7):e330-e346. 

Nair AR, Pillai AJ, Nair N. Cardiovascular Changes in Menopause. Curr Cardiol Rev. 2021;17(4):e230421187681. 

Sarma discusses the ongoing movement to highlight the different cardiovascular risks facing women, particularly during the most turbulent periods of life.

Strategic Alliance Partnership

Combatting Cardiovascular Risk in Postpartum and Menopausal Women, With Amy Sarma, MD

Linda Stein Gold, MD, is a dermatologist at Henry Ford Health. 

1 Year Data Supports Icotrokinra Versus Deucravacitinib for Psoriasis, With Linda Stein Gold, MD

Sustained Itch Reduction Observed at 1 Year of Icotrokinra in Psoriasis, With Linda Stein Gold, MD

One-year findings from a pair of pivotal phase 3 trials have been presented at the 

2026 American Academy of Dermatology (AAD) Annual Meeting

 reinforce icotrokinra's emerging profile as a high-efficacy oral option for adults with moderate-to-severe plaque psoriasis, and these data suggest the targeted oral peptide may offer certain advantages over deucravacitinib.

 at AAD, trial investigator Linda Stein Gold, MD, of Henry Ford Health, highlighted key results from ICONIC-ADVANCE 1 (NCT06143878) and ICONIC-ADVANCE 2 (NCT06220604) studies. These are 2 phase 3 analyses assessing icotrokinra not only against placebo but also in a direct head-to-head comparison with deucravacitinib, which Stein Gold noted was considered the benchmark for oral psoriasis drugs.

“We looked at these head to head, three different arms of the study, and then those patients who were on placebo were transitioned to oral [icotrokinra],” Stein Gold explained.

Adults with moderate-to-severe psoriasis were involved in 3 arms: once-daily oral icotrokinra 200 mg, placebo (transitioning to icotrokinra at the 16-week mark), and deucravacitinib 6 mg (transitioning to icotrokinra at Week 24). Stein Gold et al had tracked Investigator's Global Assessment (IGA) and Psoriasis Area and Severity Index (PASI) responses through Week 52.

In her interview, Stein Gold described icotrokinra demonstration of a rapid onset of action, noting the sustained improvement maintained across the full 52-week observation period. The depth of response in skin clearance was also noted, as early in the studies, those on icotrokinra attained a clear level of skin at roughly double the rate of those on deucravacitinib.

When deucravacitinib-treated individuals crossed over to icotrokinra at the 24-week mark, these patients’ clearance rates similarly doubled, and those gains held through Week 52. Additionally, the drug’s safety profile was strong, with the adverse event (AE) rates with icotrokinra being comparable to placebo. Stein Gold and colleagues also found infection rates came in numerically lower than those observed with deucravacitinib.

The trials also enrolled adolescent patients alongside adults, and tolerability findings were noted as consistent across age cohorts. Overall, optimism regarding icotrokinra's study program’s continuation was expressed by Stein Gold.

Disclosures: Stein Gold reported serving as an investigator, advisor, or speaker for AbbVie, Amgen, Arctis, Bristol Myers Squibb, Dermavant, Eli Lilly, Johnson & Johnson, Novartis, Pfizer, and UCB.

ICOTYDE™ (icotrokinra) one-year results confirm lasting skin clearance and favorable safety profile in once‑daily pill for plaque psoriasis. Johnson & Johnson. March 28, 2026. 

https://www.jnj.com/media-center/press-releases/icotyde-icotrokinra-one-year-results-confirm-lasting-skin-clearance-and-favorable-safety-profile-in-once-daily-pill-for-plaque-psoriasis

Campbell P. Icotrokinra, an Oral Il-23 Inhibitor, Receives FDA Approval for Psoriasis. HCPLive. March 18, 2026. Accessed March 28, 2026. 

https://www.hcplive.com/view/icotrokinra-receives-fda-approval-for-psoriasis

These 52-week, phase 3 data on icotrokinra, presented at AAD, highlight the drug's efficacy and safety among adults with moderate to severe plaque psoriasis.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

Victoria Johnson joined MJH Life Sciences in 2020 and has written for NeurologyLive, CGTLive, and is now an assistant managing editor for HCPLive and RheumatologyLive. She doesn’t have enough time for her numerous hobbies. You can reach her at vjohnson@mjhlifesciences.com.

The findings extend the radiographic dataset for risankizumab in PsA to 244 weeks — the longest such follow-up reported from the KEEPsAKE program.

Dermatology

The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

KEEPsAKE-1: Risankizumab Maintains Radiographic Nonprogression Through 5 Years in Psoriatic Arthritis

Rosmarin discussed new late-breaking data from ADVANCE-AA at AAD 2026.

Alopecia

First in Class Rezpegaldesleukin: Favorable Safety, Durable Responses in Alopecia Areata, With David Rosmarin, MD 

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

This late-breaking, phase 2 data highlights nemolizumab's clinically meaningful benefits for children with moderate-to-severe atopic dermatitis.

Atopic Dermatitis

Atopic Dermatitis condition center page, audiences can find a variety of coverage mediums for medical news and updates, including articles, video interviews, podcasts, and breaking news on dermatitis research, treatment, and drug development.

Late-Breaking Data Highlight Nemolizumab Efficacy in Children with Atopic Dermatitis

HI-PEITHO concluded use of ultrasound-facilitated catheter-directed fibrinolysis improves pulmonary embolism outcomes. 

Stroke

On the HCPLive stroke page, resources on the topics of medical news and expert insight into CVA can be found. Content includes articles, interviews, videos, podcasts, and breaking news on stroke medicine, and more.

Ultrasound-Facilitated Catheter-Directed Fibrinolysis Reduces Early Decompensation in Pulmonary Embolism

Arrhythmia

CHAMPION-AF: Left Atrial Appendage Closure Noninferior to NOACs

Soung discussed how new 52-week data support icotrokinra's recent FDA approval, marketed as Icotyde.

ICONIC-LEAD: 1 Year Icotrokinra Data Confirm Durable Psoriasis Clearance, PRO Improvements in Adults, Adolescents, With Jennifer Soung, MD

Petter Bjornstad, MD, is executive director of the UW Medicine Diabetes Institute, professor of pediatrics and medicine, and the Raisbeck Endowed Chair of Diabetes Research at the University of Washington.

REMODEL offers new mechanistic insights into semaglutide, highlighting microvascular and endothelial effects that help explain its kidney and cardiovascular benefits.

Chronic Kidney Disease

REMODEL: Mechanistic Insights Into Semaglutide in CKD, With Petter Bjornstad, MD

Chee Kay Cheung MBChB PhD, is a consultant nephrologist and honorary senior lecturer at the University of Leicester.

KDIGO updates in IgA nephropathy highlight lower proteinuria targets, improved risk tools, and an expanding landscape of targeted and combination therapies.

IgA Nephropathy

The HCPLive Berger disease page is a resource for medical news and expert insights on IgA nephropathy. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in Berger disease, and more.

IgAN Risk, Proteinuria Targets, and KDIGO Updates, With Chee Kay Cheung, MBChB, PhD

Michelle Bichchau Nguyen, MD, MBA, MPH, is an associate professor of dermatology at Tufts University School of Medicine and the director of Mohs Micrographic Surgery.


This interview at AAD 2026 highlights Nguyen's views on the biggest drivers of patient dissatisfaction in dermatology practice settings.

What Are the Biggest Drivers of Dissatisfaction in Dermatology? With Michelle Nguyen, MD, MBA, MPH

Tildrakizumab is US FDA-approved for treating adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

Latest News

Can CAR-T Cell Therapy Transform Lupus Nephritis Care? With Brad Rovin, MD

VESALIUS-CV: Evolocumab Cuts First MACE Risk in Diabetes Without Atherosclerosis

Monthly Tonlamarsen Reduces Angiotensinogen, But No Significant Difference in Blood Pressure

Combatting Cardiovascular Risk in Postpartum and Menopausal Women, With Amy Sarma, MD

Sustained Itch Reduction Observed at 1 Year of Icotrokinra in Psoriasis, With Linda Stein Gold, MD