Topics:

Muscle Weakness and Hand Discoloration in a 60-Year-Old Woman

Muscle Weakness and Hand Discoloration in a 60-Year-Old Woman

A 60-year-old black woman presented with a history of muscle weakness, Raynaud phenomenon, joint pain, and discoloration of her hands. Physical examination showed proximal muscle weakness and mild synovitis in her metacarpophalangeal joints. Laboratory evaluation revealed a mild normochromic normocytic anemia and normal renal function. Urine analysis results were benign. The patient's creatine phosphokinase (CPK) level was elevated at 3435 U/L (normal, lower than 173 U/L). Chest x-ray films revealed mild interstitial changes at the lung bases. Autoantibody test results were positive for antinuclear antibodies and for the presence of anti-Jo1 antibodies, and negative for anti–double-stranded DNA, anti-Smith, anti-U1-RNP, anti-SSA, anti-SSB, HIV, and hepatitis C virus antibodies. A photograph of the patient's hands is shown here.

What is your diagnosis?

Click here to learn why this woman's clean hands look dirty.

 
Loading comments...

By clicking Accept, you agree to become a member of the UBM Medica Community.