Topics:

Alcoholic Cirrhosis Alters Gene Expression and Worsens Brain Dysfunction

Alcoholic Cirrhosis Alters Gene Expression and Worsens Brain Dysfunction

AUSTIN, Tex., Aug. 27 -- Cirrhosis may worsen alcohol-induced brain dysfunction by altering neural gene expression, according to investigators here.

Comparison of gene expression patterns in cirrhotic and noncirrhotic alcoholics revealed widespread differences in the frontal cortex, R. Dayne Mayfield, Ph.D., of the University of Texas, and colleagues, reported in the September issue of Alcoholism: Clinical and Experimental Research.

Both astrocytes and neuronal cells were affected at the transcriptional level in cirrhotic alcoholics.

"Genes involved in neurite growth, neuronal cell adhesion, and synaptic transmission were inhibited at the mRNA level in cirrhotic alcoholics," the authors stated.

Pages

 
Loading comments...

By clicking Accept, you agree to become a member of the UBM Medica Community.