This condition features acutely tender nodules, marked erythema, and contusions that appear as a consequence of inflammation of subcutaneous fat. The eruption is associated with fever, polyarthralgia, and ankle synovitis and usually lasts 6 to 8 weeks.
Erythema nodosum can be triggered by infection and certain drugs (sulfonamides, penicillin, oral contraceptives, gold salts, NSAIDs, and aspirin). It is also associated with sarcoidosis, spondyloarthropathies, some vasculitides (hepatitis B and C, Behçet disease), cancer and, rarely, Hodgkin and non-Hodgkin lymphoma.1 Patients with inflammatory bowel disease may have erythema nodosum in association with active disease, arthritis, and uveitis. Behçet disease can occur at any time during the course of erythema nodosum.1