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Lupus Treatments Increase Risk of Infertility in Men

Lupus Treatments Increase Risk of Infertility in Men

SO PAULO, Brazil, June 28 -- Men with systemic lupus erythematosus, especially those who begin treatment with intravenous cyclophosphamide after puberty, are at risk for sperm abnormalities associated with infertility.

Compared with healthy males, lupus patients had significantly lower sperm volume (P=0.015), a lower sperm count (P=0.002) and less motile sperm (P=0.004), according to findings reported in the July issue of Arthritis & Rheumatism.

Pollyanna Maria F. Soares, M.D., of the University of So Paulo, and colleagues, said it is not possible to predict which patients will become infertile but, they said, abnormal testicular function appears to be persistent after five or more years of IV cyclophosphamide therapy.

Moreover only 20% of the lupus patients versus 80% of the controls had fathered children (P=0.0001).

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