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Refractory Bedwetting Pinned to Abnormal Prostaglandins

Refractory Bedwetting Pinned to Abnormal Prostaglandins

AARHUS, Denmark, Dec. 1 -- Bedwetting not controlled by DDAVP (desmopressin) may be caused by excess sodium and urea excretion, possibly brought on by a surfeit of prostaglandin E2, suggested researchers here.

In an overnight study comparing seven- to 14-year-olds with nocturnal enuresis with dry controls, the children with enuresis plus nocturnal polyuria excreted significantly greater amounts of sodium and urea at night than either nonpolyurics or controls, found Konstantinos Kamperis, M.D., of the University of Aarhus, and colleagues.

These children were also found to excrete prostaglandin E2 at significantly higher levels, the authors wrote in the December issue of the American Journal of Physiology-Renal Physiology.

The findings point to overzealous prostaglandin synthesis as a possible explanation for at least some of the approximately 30% of cases of nocturnal enuresis that are resistant to DDAVP.

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