High Cholesterol

Medication: Polygenic Hypercholesterolemia. Polygenic hypercholesterolemia is the most common cause of elevated serum cholesterol concentrations.

Workup: Polygenic Hypercholesterolemia. Polygenic hypercholesterolemia is the most common cause of elevated serum cholesterol concentrations.

Treatment & Management: Polygenic Hypercholesterolemia. Polygenic hypercholesterolemia is the most common cause of elevated serum cholesterol concentrations.

Polygenic Hypercholesterolemia. Polygenic hypercholesterolemia is the most common cause of elevated serum cholesterol concentrations.

Clinical Presentation: Polygenic Hypercholesterolemia. Polygenic hypercholesterolemia is the most common cause of elevated serum cholesterol concentrations.

To evaluate the association of serum -glutamyltransferase (GGT) levels with heart failure (HF) risk in the Finnish population.|Prospective population-based cohort study.|The present study, which is a part of FINRISK study, was carried out in Finland. Subject study cohorts included 18353 Finnish men and 19726 women who were 25-74years of age and free of HF at baseline. Main outcome measures HF (636 men and 445 women) during a mean follow-up of 14.5years.|Baseline measurement of different levels of serum GGT was used to predict incident HF. The multivariable-adjusted (age, sex, study area, study year, smoking, education, alcohol consumption, physical activity, valvular heart disease, body mass index (BMI), systolic blood pressure, total cholesterol at baseline, myocardial infarction and diabetes at baseline and during follow-up) HRs of HF at five GGT groups (using the 25th, 50th, 75th and 90th percentiles) were 1.00, 1.16 (95% CI: 0.97 to 1.38), 1.20 (1.00 to 1.45), 1.29 (1.04

High density lipoprotein (HDL) decreases in diabetic women more rapidly than what is observed in diabetic men. Here we aimed to study serum LCAT levels and LCAT activity in men and women with type 2 diabetes (T2DM) as well as healthy controls.|We measured serum LCAT activity and levels in 40 patients with T2DM plus 40 age-sex and body mass index (BMI)-matched controls. The correlation between LCAT levels and activity was measured in the studied groups, stratified according to gender.|Patients had a lower LCAT activity, diastolic blood pressure, fasting blood sugar, triglyceride, low density lipoprotein cholesterol and a higher LCAT levels than controls. The lower LCAT activity in patients with T2DM was significant after multiple adjustments for age, LCAT levels and BMI, using general linear model (67.9 1.8 vs. 86.5 1.8; P<0.001). Women with T2DM had a lower LCAT activity and a higher LCAT and HDL levels compared to men. The lower LCAT activity in women remained significant after

Hyperinsulinemia and the metabolic syndrome confer increased risks of endometrial carcinoma. The roles of insulin, and, insulin-like growth factor-binding proteins (IGFBPs) in the etiology of endometrial carcinoma, remain unclear. We recruited 206 patients with endometrial carcinoma and 350 healthy women to a case-control study of fasting insulin and IGFBP-related protein 1 (IGFBP-rP1) in a Chinese tertiary centre. Patients with endometrial carcinoma had higher insulin concentrations (14.8 16.7 vs. 8.1 9.4 U/mL; p < 0.001) and lower IGFBP-rP1 levels (17.5 17.2 vs. 22.4 22.8 g/L; p = 0.018) than controls. High insulin and IGFBP-rP1 levels were both positively and negatively associated with endometrial cancer (odds ratio for the highest tertile versus the lowest tertile: insulin: 4.11; 95% CI = 2.61-6.47; IGFBP-rP1: 0.38; 95% CI = 0.24-0.60). Logistic regression analysis confirmed the associations between endometrial carcinoma and fasting insulin or IGFBP-rP1 after

Nowadays, obesity is one of the most important health problems in both developed and developing countries. Recent studies have shown a significant association of obesity and its complications with birth weight. The aim of our study was to analyze the effect of birth weight on the occurrence of metabolic disorders in normal weight and obese women.|The study group included 134 females of average age 41.71 +/- 11.56 years. In these women the relationship between birth weight and anthropometric and biochemical parameters, as well as with blood pressure values was analyzed.|Our results show that women with higher birth weight had higher values of the anthropometric indicators of fat mass and distribution (such as body mass index, total fat mass, waist circumference and hip circumference), as well as higher values of high density lipoprotein-cholesterol. In contrast, the values of systolic and diastolic blood pressure and low density lipoprotein-cholesterol were lower in women with higher

Androgen deprivation therapy has a variety of well recognized adverse effects including vasomotor flushing, loss of libido, fatigue, gynecomastia, anemia and osteoporosis. This review focuses on the more recently described metabolic complications of androgen deprivation therapy including obesity, insulin resistance and lipid alterations as well as the association of androgen deprivation therapy with diabetes and cardiovascular disease.|We reviewed the medical literature using the PubMed search terms prostate cancer, androgen deprivation therapy, gonadotropin-releasing hormone agonists, obesity, insulin resistance, lipids, diabetes, cardiovascular disease and myocardial infarction. We provide a focused review and our perspective on the relevant literature.|Androgen deprivation therapy decreases lean mass and increases fat mass. It also decreases insulin sensitivity while increasing low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglycerides. Consistent

Contains NHLBI clinical guidelines for asthma, cholesterol and cholesterol screening, hypertension, and obesity.

Contains NHLBI clinical guidelines for asthma, cholesterol and cholesterol screening, hypertension, and obesity.

Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.