Assumption #4. Osteoarthritis (OA) of the knee almost always progresses over time.
Evidence from a three-year study of 1,447 participants in the Osteoarthritis Initiative who had radiographically evident and symptomatic OA showed that half reported less knee pain at 48 months than at 12 months. About a third of patients reported having no pain at one or more followup visits, and only 36% reported a higher pain score at 48 months. Symptoms worsened progressively for only 12.6% of subjects.