Survival is reduced significantly in patients who have systemic sclerosis (SSc) with pulmonary hypertension (PH) combined with advanced interstitial lung disease (ILD) compared with patients with SSc who have isolated pulmonary arterial hypertension (PAH). The prognosis for patients in the former... More »
The cardiovascular properties of serotonin (5-HT) have been known for some time—its name reflects its presence in serum and its action in increasing vascular tone. Serotonergic medications are routinely used to treat depressive and anxiety disorders, and the association of depression with... More »
Idiopathic intracranial hypertension is a cause of vision loss in HIV-positive patients. In many patients with controlled HIV disease, idiopathic intracranial hypertension develops without any other apparent cause. More »
At what blood pressure is it prudent to treat newly diagnosed hypertension with 2 antihypertensive agents, and what criteria should guide selection of the 2 drugs? More »
Systolic hypertension is an independent risk factor for coronary artery disease, stroke, and end-stage renal disease. Nonpharmacological interventions for systolic hypertension include limitation of dietary sodium and alcohol intake along with weight reduction and aerobic exercise. More »
An oral renin inhibitor, aliskiren, recently became available. Does it have any advantages over angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs)? More »
Treatment of hypertension can minimize both microvascular and macrovascular complications of diabetes and helps prevent nephropathy and cardiovascular events. More »
VIENNA -- For patients in the early stages of pulmonary arterial hypertension, the use of bosentan (Tracleer) appears to slow the progressive worsening of symptoms. More »
