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A brief description of the clinical highlights and a single image: your best diagnostic guess? 

Image IQ

This man was born with digital deformities. X-rays show absent middle and distal 2nd, 3rd, and 4th phalanges with tapering proximal phalanges and tapering of the distal 5th phalanx and distal 1st phalanx. No TBX5 gene mutation. What’s your diagnosis?

A 5-year-old boy had pain and weakness in his legs and had trouble climbing stairs. He had a dramatic rise in CPK followed by erythematous papules on the hands, as shown, and a rash around the eyelids. Which diagnosis is most likely?

A 6-year-old boy had a 1-month history of an intensely pruritic “rash” on the left dorsal foot and left lower leg. He had a recent history of walking barefoot on a beach in south Florida where dogs are allowed. What's your diagnosis?

A 4-year-old, previously healthy girl presented with large, tense bullae involving up to 40% of her body surface area. Her parents described a 12-day history of itchy, papulovesicular lesions that had progressed into large blisters. Your dx?

A toddler from Nigeria, whose parents remained there ill with AIDS, presented with a fever and a widespread itchy eruption. Tests for HIV infection were positive. Which systemic etiologies can be ruled out when such an eruption presents?

Erythema migrans, the characteristic rash of Lyme disease, often has a bull’s-eye appearance. Which of the following additional factors can help the diagnosis?

A 50-year-old African American woman with type 2 diabetes mellitus and hypertension was admitted with bilateral knee and thigh pain and swelling of both knees. MRI showed extensive edema in the distal thigh and gastrocnemius muscles and in subcutaneous fat. Fluid was seen at the short head of the left biceps femoris. The findings were consistent with diabetic myonecrosis. Which of the following statements about this condition is/are true?

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