Diffusion tensor MRI tractography studies typically show diffusivity abnormalities in MS patients that are not seen in controls and that correlate with various measures of clinical severity. Here, the technology was used to reconstruct white matter tracts in healthy control subjects. On the top row are the corpus callosum, fornix, and inferior fronto-occipital fasciculus; on the bottom, the uncinate, arcuate, and cingulum fasciculus. Hard exudates composed of lipid and protein deposits are seen and a cotton-wool spot (nerve fiber layer infarct) is also visible.
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