The lesion seen here, caused by HPV-16, is a papillary squamous cell carcinoma in situ. HPV-16 is highly associated with this orophayrngeal cancer and premalignant diseases.1-3 It is currently the primary cause of oral cancer in men.
1. Chaturvedi AK, Engels EA, Pfeiffer RM, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29:4294-4301.
2. James SD. Oral sex linked to rise in men’s throat cancer. ABC News. October 20, 2010. http://abcnews.go.com/Health/ReproductiveHealth/hpv-oral-cancers-rise-oral-sex-popular-spread/story?id=11916068#.T891Lb9XsmI. Accessed June 6, 2012.
3. Syrjänen S, Lodi G, von Bültzingslöwen I, et al. Human papillomaviruses in oral carcinoma and potentially malignant disorders: a systematic review. Oral Dis. 2011;17(suppl 1):58-72.