Diuretics + Antihypertensives + NSAIDs = Increased Risk of Kidney Injury
Patients who take a combination of medications that include diuretics, ACE inhibitors or angiotensin receptors blockers, and NSAIDs may be at an increased risk for acute kidney injury, according to the results of study published last week in BMJ.
The authors of this study conducted a retrospective cohort analysis using data on almost half a million antihypertensive drug users taken from the UK Clinical Practice Research Datalink.
In the cohort, 2,215 cases of acute kidney injury were identified. Results indicated that use of 2 of the 3 drugs—diuretics, antihypertensive, and NSAIDs, was not associated with an increased risk for kidney injury. However, the combination of the 3 drugs significantly increased risk, with a rate ratio of 1.31.
Read the full results of the study here.