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PHOTO CLINIC

Emphysematous Pancreatitis in a 61-year-old Man
January 29, 2013

Emphysematous pancreatitis is typically managed with broad-spectrum antibiotics and early surgical debridement. Here, a case that supports more recent evidence for conservative therapy.

Ecchymosis: A Photo Essay
January 28, 2013

This compact slide show provides a range of visual presentations of ecchymosis.

Condylomata Acuminata (Severe External Genital Warts)
January 28, 2013

Extensive condylomata acuminata are beyond the capacity of all topical therapies. The area was initially treated by carbon dioxide laser ablation, and residual small foci of infection were subsequently treated with topical 5% imiquimod cream.

 
CLINICAL TRIALS
Abstract 3246: TMS1 / ASC is critical for primary ciliogenesis and participates in cell migration
cancerres.aacrjournals.org - 6/3/12
Abstract SY29-03: Regulation and function of the Hippo-YAP pathway in organ size, tumorigenesis, and metastasis
cancerres.aacrjournals.org - 6/3/12
PLoS ONE: Inhibition of Neuroblastoma Tumor Growth by Targeted Delivery of MicroRNA-34a Using Anti-Disialoganglioside GD2 Coated Nanoparticles
www.plosone.org - 5/24/12
 
NEWS
Sleep Apnea Doubles Risk for Stroke Precursor in Elderly
www.consultantlive.com - 3/15/13
H pylori and Peptic Ulcer in Low-dose Aspirin Users: Testing Useful
www.consultantlive.com - 3/11/13
Celiac Disease and Inflammatory Bowel Disease: Co-Occurrence Increases Pancolitis
www.consultantlive.com - 3/11/13
 
PATIENT RESOURCES
Breast cancer
ghr.nlm.nih.gov - 3/18/13
Lynch syndrome
ghr.nlm.nih.gov - 3/18/13
NBN
ghr.nlm.nih.gov - 3/18/13
 
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PSA SCREENING DEBATE
 
FEATURED CONTENT
May 17, 2013
Lower Back Pain in an Elderly Man With a History of Localized Prostate Cancer
A 70-year-old man with a history of localized prostate cancer treated with whole-pelvis radiation therapy with a boost to the prostate, in conjunction with androgen deprivation therapy 7 years prior, presented with lower back pain. A bone scan revealed an area of activity in the sacrum. What is the most likely diagnosis? More »
May 17, 2013
New AUA Guidelines for Prostate Cancer Screening
The American Urological Association (AUA) released a new clinical guideline detailing recommendations for the use of prostate cancer screening in average-risk men based upon evidence from a systematic literature review. The guideline, which was announced during the 2013 AUA Annual Meeting, recommends that men aged 55 to 69 years who are considering undergoing prostate cancer screening should talk with their physicians about the benefits and risks of screening. More »
May 16, 2013
Radium-223 Gets Early FDA Nod for Bone Mets in Castration-Resistant Prostate Cancer
Radium-223 dichloride (Xofigo) received FDA approval for the treatment of symptomatic metastatic castration-resistant prostate cancer that has metastasized to the bone but no other organs. More »
May 15, 2013
Secondary Hormone Therapy for Castration-Resistant Prostate Cancer
The majority of patients with systemic prostate cancer treated with androgen deprivation therapy (ADT) will develop castration-resistant prostate cancer (CRPC). More »
May 13, 2013
Study: Cholesterol Drugs Reduced Risk of Prostate Cancer Death
A cohort-based study found that men with prostate cancer who took cholesterol-lowering statins had a lower risk of dying from their prostate cancer. More »
Showing 1 - 5 of 442 results.
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JOURNAL SCAN
WJSO | Full text | Peripheral T-cell lymphoma presenting as testicular mass; a diagnostic challenge
www.wjso.com - 3/14/13
T-cell lymphomas involve the testis infrequently, which deserve special attention because of the poor prognosis and the need to make an appropriate diagnosis, which could lead to a better therapeutic strategy.|T-cell lymphomas involve the testis infrequently, which deserve special attention because of the poor prognosis and the need to make an appropriate diagnosis, which could lead to a better therapeutic strategy.
Testicular cancer: Extragonadal germ cell tumour location and cause of death
feeds.nature.com - 2/25/13
Early development of the metabolic syndrome after chemotherapy for testicular cancer
annonc.oxfordjournals.org - 2/15/13
Background

The metabolic syndrome (MS) might increase the risk of cardiovascular disease in testicular cancer (TC) survivors. We investigated its prevalence, development, vascular implications, and the role of gonadal function.

 Methods

TC survivors treated with chemotherapy and follow-up ≥3 years (N = 370, study I) were retrospectively evaluated for the development of cardiovascular risk factors. A subgroup followed 3–20 years (N = 173, study I

British Journal of Cancer
www.nature.com - 1/30/13
The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to encourage communication of the very best cancer research from laboratories and clinics in all countries. The breadth of its coverage, its editorial independenc
Testicular cancer in Europe and the USA: survival still rising among older patients
annonc.oxfordjournals.org - 1/21/13
Background

Despite high curability, some testicular cancer (TC) patient groups may have increased mortality. We provide a detailed age- and histology-specific comparison of population-based relative survival of TC patients in Europe and the USA.

 Design

Using data from 12 European cancer registries and the USA Surveillance, Epidemiology and End Results 9 database, we report survival trends for patients diagnosed with testicular seminomas and nonseminomas betwee

 
MEDLINE
Exercise improves fatigue during and after breast and prostate cancer treatment, with benefits seen for aerobic exercise
ebn.bmj.com - 2/27/13

Commentary on: Cramp F, Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev 2012;11:CD006145

Implications for practice and research

  • Encouraging cancer patients to follow a structured exercise programme reduces self-reported fatigue.

  • The optimal exercise programme (aerobic, resistance, mind–body or a combined programme) remains undecided;

    • Preoperative statin therapy is not associated with biochemical recurrence after radical prostatectomy: our experience and meta-analysis.
    pubmed.gov - 9/1/12
    The effect of statins on prostate cancer recurrence has been investigated in several studies with inconsistent results. We investigated whether statins were associated with biochemical recurrence in a large cohort of men after radical prostatectomy. We also performed a meta-analysis of existing studies.|A total of 1,446 patients who underwent radical prostatectomy at New York University were followed a median of 57 months for biochemical recurrence events. Baseline demographic and clinical characteristics were compared between 437 statin users and 1,009 nonusers. Kaplan-Meier curves and Cox models were used to examine biochemical recurrence-free survival by statin use. A meta-analysis was performed with data from our cohort and 5 published studies using the random effects model.|Statin users were slightly older and more likely to have diabetes (p <0.01). They were similar to nonusers in race and body mass index. Although preoperative prostate specific antigen and tumor stage were
    Dexamethasone plus somatostatin-analog manipulation as bone metastasis microenvironment-targeting therapy for the treatment of castration-resistant prostate cancer: a meta-analysis of uncontrolled studies.
    pubmed.gov - 8/1/12
    Antisurvival factor therapy for prostate cancer cells (ASF) in castration-resistant prostate cancer, is a hormonal manipulation consisting of a somatostatin analog, which reduces the growth hormone-dependent, systemic IGF-1 production and of oral dexamethasone, which supresses the urokinase type plasminogen activator -mediated "local" increase of IGF-1 bioavailability in the bone metastases, while the patients continue on a luteinizing hormone-releasing hormone analog therapy. Aim: To revisit relevant evidence and provide a quantitative summary estimate of ASF efficacy.|A structured review of relevant literature and a meta-analysis of uncontrolled studies and cohorts within trials was carried out at tertiary academic centers. A computerized literature search was conducted in the electronic database Medline from inception to January 2012. To be eligible for inclusion, a study had to report data on the efficacy of ASF in the treatment of castration-resistant prostate cancer,
    The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis.
    pubmed.gov - 8/1/12
    Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored 123-aa protein related to the cell-proliferation inhibition and/or cell-death induction activity. Many studies had reported the role of PSCA rs2294008 C > T and rs2976392 G > A polymorphisms on gastric cancer risk.|To investigate a more precise estimation of the relationships, we performed a meta-analysis on 9 case-control studies included 10,746 cases and 9,158 controls. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association.|For PSCA rs2294008 C > T polymorphism, there was a significantly increased risk of gastric cancer in all genetic models (TT/TC vs. CC: OR = 1.61, 95 % CI = 1.35-1.91; TT vs. TC/CC: OR = 1.33, 95 % CI = 1.24-1.42). Similar results were also observed for PSCA rs2976392 G > A polymorphism (AA/AG vs. GG: OR = 1.69, 95 % CI = 1.24-2.31; AA vs. AG/GG: OR = 1.36, 95 % CI = 1.24-1.50). In the stratified analysis by ethnicity of rs2294008, an
    Systematic review and meta-analysis of insulin therapy and risk of cancer.
    pubmed.gov - 8/1/12
    Recent epidemiological studies suggest that treatment with insulin may promote cancer growth. The present systematic review and meta-analysis of published observational studies was conducted to assess the risk of cancer during treatment with insulin. A search of online database through January 2011 was performed and examined the reference lists of pertinent articles, limited to observational studies in humans. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated with a random-effects model. Fifteen studies (five case-control and ten cohort studies) were included, with 562,043 participants and 14,085 cases of cancer. Insulin treatment was associated with an increased risk of overall cancer [summary RR (95% CI)=1.39 (1.14, 1.70)]. Summary RR (9% CI) for case-control studies was 1.83 (0.99, 3.38), whereas RR for cohort studies was 1.28 (1.03, 1.59). These results were consistent between studies conducted in the USA and in Europe. For studies that included
     
    PRACTICE GUIDELINES
    Guide to Clinical Preventive Services, 2010-2011: Section 2
    www.ahrq.gov - 8/31/10
    Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.
    Table 1. Prostate Cancer Treatment and Hospitalization Following Prostate Biopsy
    www.acponline.org -
    Internal Medicine - Doctors for Adults
    Table 3. Men's Preferences and Practices for Prostate Cancer Screening or Treatment
    www.acponline.org -
    Internal Medicine - Doctors for Adults



     
    FROM PHYSICIANS PRACTICE
    Primary Care Can't Thrive Without Nurse Practitioners
    Courtney H. Lyder, ND,  May 17, 2013
    With a projected shortfall of primary-care physicians, it's time for alternate solutions to patient care. Nurse practitioners are one logical remedy.
    VWhat Physicians Can Learn from the Allscripts EHR Lawsuit
    Marisa Torrieri,  May 16, 2013
    Lawsuit prompts question: What should physicians do to ensure they end up with a great EHR instead of buyer’s remorse?
    Eight Ways ICD-9 Will Still Matter to Medical Practices
    Brenda Edwards, CPC,  May 15, 2013
    What should your medical practice do with your ICD-9-CM book after October 1, 2014? Keep it.
    Seven Ways Technology Can Speed Up Patient Collections
    Cheyenne Brinson,  May 15, 2013
    Failing to adopt widely available billing and collections technology can cost medical practices big. Here's how to do it right.
    Four Reasons Private Medical Practice is Becoming Extinct
    Carol Stryker,  May 15, 2013
    It’s becoming increasingly difficult for private medical practices to thrive. Here’s what’s driving the trend toward consolidation.
     

     
     
    COMMENTS