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NEWS
New Oral Agent, Biologics to Star at ACR
www.medpagetoday.com - 11/7/12
ACR Puts Out Gout Guidelines (CME/CE)
www.medpagetoday.com - 9/28/12
Rheumatology: Progress in Some Areas, Others Lag (with video)
www.medpagetoday.com - 6/11/12
 
CLINICAL TRIALS
Effectiveness and Safety of Enbrel (Etanercept) in Rheumatoid Arthritis Subjects Who Have Failed Remicade (Infliximab)
www.clinicaltrials.gov -
Safety and Efficacy Study of Etanercept (Enbrel) In Children With Systemic Onset Juvenile Rheumatoid Arthritis
www.clinicaltrials.gov -
Relaxation Response Training for the Treatment of Rheumatoid Arthritis
www.clinicaltrials.gov -

 
PATIENT RESOURCES
What Is Restless Legs Syndrome?
www.nhlbi.nih.gov - 3/25/13
What Is Antiphospholipid Antibody Syndrome?
www.nhlbi.nih.gov - 3/24/13
Who Is at Risk for Heart Disease?
www.nhlbi.nih.gov - 3/24/13
 
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Rheumatic Diseases
 
CLINICAL NEWS & KNOWLEDGE
April 1, 2008
Biologics Are Changing the Face of Psoriasis Treatment
As dermatologists' use of biologic drugs for psoriasis grows, MCOs must take an increasingly active role in managing the near-term utilization of these high-cost agents while also taking into account that some of the "payback" for these drugs comes in the form of long-term costs avoided. Meanwhile,... More »
March 28, 2008
Pregnancy Dilemmas in Rheumatologic Disease
Pregnant women with rheumatologic disease face dilemmas created by their pregnancy and are at increased risk for complications. Some dilemmas are created by the medications that are used to control inflammation; others are created by disease activity or laboratory values. Dilemmas include fetal risk... More »
March 28, 2008
Injection of the wrist and ulnar styloid
The wrist, a complex joint, often is involved in inflammatory arthritis, such as rheumatoid arthritis or psoriatic arthritis. Wrist synovitis causes pain, swelling, and loss of extension. Extension of the synovial lining may lead to synovitis of the ulnar styloid. During injection of the... More »
March 27, 2008
Fighting fibromyalgia: Five key issues
ABSTRACT: Physicians treating patients with fibromyalgia syndrome (FMS) should rule out coexisting disorders and establish possible inducing factors. They can work with patients to address their symptoms by providing patient education, instilling a sense of self-worth, advising avoidance of... More »
March 26, 2008
Pregnancy dilemmas in rheumatologic disease
<em>Pregnant women with rheumatologic disease face dilemmas created by their pregnancy and are at increased risk for complications. Some dilemmas are created by the medications that are used to control inflammation; others are created by disease activity or laboratory values. Dilemmas include... More »
March 25, 2008
Overcoming obstacles in musculoskeletal medicine
More »
March 23, 2008
Depression with osteoarthritis: Life events and coping factors increase risk
More »
February 27, 2008
What role do occupational exposures play in RA?
Occupational exposure to various chemicals, minerals, and toxins may increase the risk of rheumatoid arthritis (RA). Relationships between silica exposure and lung, renal, and autoimmune disease have been observed. Although a relationship between silica exposure and RA has been identified, it is... More »
February 25, 2008
Sharing Decisions in Gout: Better Communication for Better Outcomes
More effective communication can improve both adherence to and outcomes of gout treatment regimens. More »
February 24, 2008
Spotting the early warning signs of aggressive RA
Recent advances in drug therapies for rheumatoid arthritis (RA) have increased the importance of early intervention. Several serological testing and imaging techniques help facilitate early diagnosis. C-reactive protein level and erythrocyte sedimentation rate have limitations in predicting RA.... More »
Showing 541 - 550 of 634 results.
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JOURNAL SCAN
Prevention and Control of Meningococcal Disease
www.cdc.gov - 3/22/13
. Search The CDC. Note: Javascript is disabled or is not supported by your browser. For this reason, some items on this page will be unavailable. For more information about this message, please visit this page: Add this to. Prepared by. Amanda C.
EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis
ard.bmj.com - 3/21/13
Objective

To develop evidence-based recommendations on the use of imaging of the joints in the clinical management of rheumatoid arthritis (RA).

Methods

The task force comprised an expert group of rheumatologists, radiologists, methodologists and experienced rheumatology practitioners from 13 countries. Thirteen key questions on the role of imaging in RA were generated using a process of discussion and consensus. Imaging modalities included were conventional radiog

Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies
ard.bmj.com - 3/21/13
Objective

Anticitrullinated protein antibodies (ACPA) are a major risk factor for bone loss in rheumatoid arthritis (RA). We have recently shown that ACPA directly induce bone loss by stimulating osteoclast differentiation. As ACPA precede the clinical onset of RA by years, we hypothesised that ACPA positive healthy individuals may already show skeletal changes.

Methods

We performed a comparative micro-CT analysis of the bone microstructure in the metacarpophalange

Predictors of work disability during the first 3 years after diagnosis in a national rheumatoid arthritis inception cohort
ard.bmj.com - 3/21/13
Objective

To identify predictors of sick leave and disability pension in patients with early rheumatoid arthritis (RA).

Methods

Individuals aged 19–59 years diagnosed with early RA (≤12 months symptom duration) were identified in the Swedish Rheumatology Quality Register (1999–2007; n=3029). We retrieved days of sick leave and disability pension from the Swedish Social Insurance Agency and baseline predictors of total work days lost during

Arthritis Research & Therapy | Abstract | Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study
arthritis-research.com - 3/21/13
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathology of Rheumatoid Arthritis (RA), particularly as vulnerable personality types are exposed to chronic stress. Emotions are powerful modulators of stress responses. However, little is known about whether patients with RA process emotions differently to matched controls. In this study we: 1) assessed whether the trait emotional intelligence (trait EI) scores of patients with RA differ from healthy controls at the
 
MEDLINE
Gout--current diagnosis and treatment.
pubmed.gov - 8/1/09
Because of the changing dietary habits of an aging population, hyperuricemia is frequently found in combination with other metabolic disorders. Longstanding elevation of the serum uric acid level can lead to the deposition of monosodium urate crystals, causing gout (arthritis, urate nephropathy, tophi). In Germany, the prevalence of gouty arthritis is estimated at 1.4%, higher than that of rheumatoid arthritis. There are no German guidelines to date for the treatment of gout. Its current treatment is based largely on expert opinion.|Selective literature review on the diagnosis and treatment of gout.|Asymptomatic hyperuricemia is generally not an indication for pharmacological intervention to lower the uric acid level. When gout is clinically manifest, however, acute treatment of gouty arthritis should be followed by determination of the cause of hyperuricemia, and long-term treatment to lower the uric acid level is usually necessary. The goal of treatment is to diminish the body's
Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases.
pubmed.gov - 3/17/09
Nitric oxide (NO), which is produced from L-arginine by the nitric oxide synthase (NOS) family of enzymes, is an important second-messenger molecule that regulates several physiological functions. In endothelial cells, it relaxes smooth muscle, which decreases blood pressure. Macrophage cells produce NO as an immune defense system to destroy pathogens and microorganisms. In neuronal cells, NO controls the release of neurotransmitters and is involved in synaptogenesis, synaptic plasticity, memory function, and neuroendocrine secretion. NO is a free radical that is commonly thought to contribute to oxidative damage and molecule and tissue destruction, and thus it is somewhat surprising that it has so many significant beneficial physiological effects. However, the cell is generally protected from NO's toxic effects, except under certain pathological conditions in which excessive NO is produced. In that case, tissue damage and oxidative stress can result, leading to a wide variety of
Advances in understanding calcium-containing crystal disease.
pubmed.gov - 3/1/09
Calcium pyrophosphate dihydrate and basic calcium phosphate crystals are the two most common calcium-containing crystals involved in rheumatic diseases. Recent literature concerning their role in the pathogenesis of osteoarthritis is reviewed.|In some instances, these calcium crystals might worsen osteoarthritis cartilage destruction. Laboratory investigations have identified determinants of cartilage calcification, especially a better characterization of matrix vesicle content and a better understanding of the regulation of inorganic pyrophosphate and phosphate concentration. In-vitro studies have highlighted new pathogenic mechanisms of calcium crystal-induced cell activation. Several intracellular signalling pathways are activated by calcium crystals. Recent studies suggested the implication of the inflammasome complex and a pivotal role for IL-1 in pseudogout attacks and chondrocyte apoptosis in basic calcium phosphate crystal-related arthropathies.|Animal models of osteoarthritis
Workplace impacts of anti-TNF therapies in rheumatoid arthritis: review of the literature.
pubmed.gov - 2/1/09
Rheumatoid arthritis (RA) causes pain and serious functional impacts and substantially affects patients' daily lives, including their ability to work.|This review examines recent studies of patients with RA treated with TNF antagonists and the impacts these therapies have on the workplace.|A total of 133 articles and 14 poster abstracts were reviewed that matched specific criteria.|The results of early studies of TNF antagonists varied regarding their effects on patients with RA in the workplace. However, recent studies of adalimumab showed positive impacts across a range of workplace burdens. Treatments such as adalimumab may help employees with RA to remain in the workforce and lead to reduced workplace costs to the employers and employees.
Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma.
pubmed.gov - 1/1/09
In recent years, pharmaceutical companies have increasingly focused on phosphoinositide 3-kinases delta (PI3Kdelta) and gamma (PI3Kgamma) as therapeutic targets for the treatment of inflammatory and autoimmune diseases. All class 1 PI3-kinases (alpha/beta/gamma/delta) generate phospholipid second messengers that help govern cellular processes such as migration, proliferation, and apoptosis. PI3K delta/ gamma lipid kinases are mainly restricted to the hematopoetic system whereas PI3K alpha/beta are ubiquitously expressed, thus raising potential toxicity concerns for chronic indications such as asthma and rheumatoid arthritis. Therefore, the challenge in developing a small molecule inhibitor of PI3K is to define and attain the appropriate isoform selectivity profile. Significant advances in the design of such compounds have been achieved by utilizing x-ray crystal structures of various inhibitors bound to PI3Kgamma in conjunction with pharmacophore modeling and high-throughput screening.
 
PRACTICE GUIDELINES
National Guideline Clearinghouse | Guidelines by Topic: Rheumatic Heart Disease
www.guidelines.gov -
NGC is the National Guideline Clearinghouse.
National Guideline Clearinghouse | Guidelines by Topic: Rheumatic Fever
www.guidelines.gov -
NGC is the National Guideline Clearinghouse.
Table 1. Basic Statistics on the Primary Outcome in a Trial of Cyclosporine in Patients with Severe Rheumatoid Arthritis
www.acponline.org -
Internal Medicine - Doctors for Adults



 
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What should your medical practice do with your ICD-9-CM book after October 1, 2014? Keep it.
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Four Reasons Private Medical Practice is Becoming Extinct
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It’s becoming increasingly difficult for private medical practices to thrive. Here’s what’s driving the trend toward consolidation.
 

 
 
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