Serial axial T2-weighted (top row) and postcontrast T1-weighted (bottom row) spin-echo MRI images of brain performed at baseline, month 1, and month 2, in a patient with relapsing-remitting MS. Multiple hyperintense lesions, which suggest multifocal white-matter pathology, are visible on T2-weighted image at baseline. On postcontrast T1-weighted examination, some of these lesions are contrast-enhanced, which indicates local disruption of blood–brain barrier. New contrast-enhancing lesions can be observed at month 1 and month 2, which indicate dissemination of disease.
