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Carbon Monoxide Not Linked to Pollution-Driven Pediatric Pneumonia

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Investigators assessing the link from CO to pneumonia risk—and the benefit of biomass-fueled cookstoves in reducing them—find it is not very distinct.

Kevin Mortimer, PhD

Carbon monoxide (CO) may not be the most accurate gauge for indoor air pollution exposure in certain settings, according to a new study which assessed its association with pediatric pneumonia.

In a new interventional trial conducted by an international team of investigators in rural Malawi, Kevin Mortimer, PhD, and colleagues sought to understand the link between household air pollution and pneumonia in children aged ≤5 years old, as well as the effects of a biomass-fueled cookstove on personal indoor air pollution exposure.

Fuel efficient biomass cookstoves have been shown to potentially reduce CO emissions common in cooking, though quantification is limited by the diverse production of such items.

Mortimer, of the Liverpool School of Tropical Medicine, and team noted that indoor air pollution exposure has been proven to link with increased pediatric pneumonia risk in low- and middle-income countries—but exposure-response data remains limited. The role of biomass-fueled cookstoves in reducing exposure, they added, is also unmeasured.

Participating children were cluster-randomized as part of the biomass-fueled cookstove intervention. Investigators assessed personal exposures to CO over a continuous 48-hour measurement, as well as a transcutaneous carboxyhemoglobin (COHb) measurement six-monthly. Analyses to interpret exposure response and multi-variable factors were conducted.

Mortimer and colleagues had recruited 1805 children randomized to either intervention (n = 928) or control (n = 877). Mean participant age was 25.6 months, with an almost even ratio of females (50.6%).

There was no observed association between neither CO (IRR = 1.0; 95% CI, 0.97-1.01; P = .53) nor COHb (IRR = 1.0; 95% CI, 0.99-1.00; P = .41) in children who experienced pneumonia versus those who did not.

In assessing the biomass-fuel cookstove intervention, the team observed an approximate 8% reduction in mean CO exposure among intervention (0.34 ppm; IQR, 0.15-0.81) and control (0.37 ppm; IQR, 0.15-0.97) groups. Group difference in means was 0.46 (95% CI, -0.95 to .012; P = .06).

Investigators concluded the children were exposed to low rates of CO, with no shown association between CI and pneumonia incidence, and no effect of the biomass-fueled cookstove intervention on their initial exposure.

“These findings suggest that CO may not be an appropriate measure of household air pollution exposure in settings like rural Malawi and that there is a need to develop ways to directly measure particulate matter exposures in young children instead,” they wrote.

The study, “Pneumonia and exposure to household air pollution in children under the age of 5 in rural Malawi: findings from the Cooking And Pneumonia Study (CAPS),” was published online in CHEST Journal.


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