L. Silvia Munoz-Price, MD, PhD
Living near a farm could increase the risk for Clostridioides difficile
Investigators, led by L. Silvia Munoz-Price, MD, PhD, Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, linked the location of a patient’s residence to asymptomatic carriage of toxigenic C. difficile
in a 3043-patient cohort study.
“Residential proximity to livestock farms were all significantly associated with a higher likelihood of a positive C. difficile
test result,” the authors wrote. “Residential proximity to livestock farms more than doubled the probability of C. difficile
colonization in patients admitted to non–hematology-oncology units.”
represents the most frequent health care-associated infection in the US, but it
can be acquired both in hospitals and community settings. About 65% of cases in the US and 74% of cases in Europe were associated with a health care setting, suggesting environmental factors could be significant causes of the infection.
According to the US Centers for Disease Control and Prevention (CDC) in 2015, there are approximately 453,000 cases of C. difficile
infections annually, with an associated annual mortality of 29,300 patients.
Livestock farms particularly carry an increased likelihood of infections due to exposure to higher loads of C. difficile
through water runoff and substances that disrupt the intestinal microbiome.
The retrospective cohort was conducted between May 2017 and June 2018 at Froedtert Memorial Lutheran Hospital, a 565-bed teaching-affiliated hospital in Wisconsin. All patients underwent C. difficile
screening using a nucleic acid amplification test at hospital admission. Stool samples were also collected for C. difficile
The investigators sought a positive result on the C. difficile
screening tests performed within 72 hours of hospital admission as the main outcome of the study.
The team also performed multivariable logistic analysis on a stratified sample of patients based on hematology-oncology admission status. Through this analysis, the investigators found that patients admitted to the hematology-oncology units were 35% more likely to be colonized with C. difficile
However, there were no significant association between the patients sociodemographic and economic characteristics or health care and environmental exposures with the likelihood of a positive C. difficile
Recent history of hospitalization—hospitalization within the preceding 6 months—increased the likelihood of colonization by 70% (OR, 1.66; 95% CI, 1.06-2.61).
Women also had 60% greater colonization than men (OR, 1.60; 95% CI, 1.03-2.46).
On the other hand, patients not admitted to a hematology-oncology unit with comorbidities had an increased likelihood for colonization by more than 4 times.
Overall, a shorter distance between a residence and a livestock farm is associated with an increased rate of C. difficile
colonization (OR, .68; 95% CI, .49-.90).
The investigators suggested future studies examine the link between C. difficile
and livestock farms in other geographic areas and the underlying mechanisms of the association.
The study, “Association Between Environmental Factors and Toxigenic Clostridioides difficile Carriage at Hospital Admission
,” was published online in Infectious Diseases