Abigail Brooks is an assistant managing editor for 

She joined MJH Life Sciences in August 2023 shortly after graduating from Monmouth University where she earned her BA in Communication with a concentration in Public Relations/Journalism and later an MA in Interactive Digital Media. She enjoys traveling, running, and reading books. She can be reached at abrooks@mjhlifesciences.com.

 care has entered a new era defined by rapid therapeutic expansion and increasing clinical complexity. Patients are living longer, new pharmacologic and device-based therapies are reshaping prognosis, and once-fatal diagnoses are now managed with durable strategies.

However, with new medications comes an increased medication burden for patients. Quadruple therapy - including SGLT2 inhibitors, beta-blockers, MRAs, and ARNIs - has become a cornerstone of postoperative therapy, with the goal of reducing morbidity and mortality after hospital discharge. The sheer number of pills required for this therapy, as well as the need for increased clinician oversight, substantially increases the time and resources invested in care.

Notably, this progress has also introduced difficult decision-making, heavier medication burdens, and the need for highly coordinated subspecialty care. According to Manreet Kanwar, MD, a professor of medicine at the University of Chicago Medicine and director of the Heart Failure and Pulmonary Hypertension program, delivering optimal outcomes today requires more than access to advanced treatments. It demands an integrated system built specifically to manage the sickest patients.

Kanwar explains that the heart failure program at UChicago Medicine has evolved to meet that challenge, featuring a team of 12 dedicated heart failure physicians who treat patients across the full spectrum of disease, from early-stage heart failure to those requiring mechanical circulatory support or heart transplantation. She emphasizes that a major differentiator of the program is its concentration of advanced heart failure expertise, particularly for patients who have failed standard medical therapy and present in critical condition.

Many of these individuals require evaluation for left ventricular assist devices (LVADs), temporary mechanical support, or transplant. She notes that careful patient selection, multidisciplinary review, and timely escalation of care are essential for achieving favorable outcomes.

Kanwar also points to pulmonary hypertension as a growing focus. Under cardiology leadership, the relaunched program provides comprehensive inpatient and outpatient management.

“This is a very unique patient population, in some ways similar to heart failure, and in some ways not necessarily, because these patients almost always have problems or issues with the right side of the heart, unlike the traditional heart failure, where they have issues with the left side of the heart,” she said. “We see these patients in our clinic, we start them on medical therapy, we work closely with our pulmonary as well as lung transplantation colleagues, because many of these patients require those kinds of therapies.”

One of the most transformative areas, according to Kanwar, has been cardiac amyloidosis. Once associated with limited treatment options and poor survival, the condition now represents a rapidly advancing field. She describes how structured diagnostic pathways, subtype-specific management, and access to multiple clinical trials, particularly those targeting transthyretin, have changed the outlook for patients. The program now follows hundreds of individuals with cardiac amyloid, reflecting both increased awareness and improved detection.

Pharmacologic innovation has similarly reshaped the broader heart failure landscape. Kanwar explains that contemporary guideline-directed medical therapies reduce hospitalizations and prolong survival across multiple heart failure subtypes. However, she acknowledges that these benefits often come with increased pill burden, especially in patients with diabetes, kidney disease, and hypertension. Balancing medication complexity with measurable outcome gains is an ongoing challenge requiring individualized assessment and shared decision-making.

Beyond clinical interventions, Kanwar underscores the importance of psychosocial support. Recurrent hospitalizations and progressive symptoms can take a profound emotional toll. Integrated social work and behavioral health resources, she notes, are essential components of comprehensive heart failure care.

“[Heart failure] is a disease that often does not come in isolation. These patients have, for example, diabetes, high blood pressure, they're more likely to have other issues like kidney failure, sometimes stroke and anemia,” she explained. “These patients then end up back in the hospital often, and this interplays into the significant burden of depression… We try to support them, of course, through medical options, but also ably supported by our colleagues, including in social work and psychology, and also sometimes we refer them to psychiatry. We may not be best trained to suit those needs, but we recognize them and try to connect the dots for these patients.”

Additionally, psychosocial support has the capacity to increase adherence to practical preventive factors, such as the well-known Life’s Essential 8. According to data from the American Heart Association (AHA), factors such as smoking, obesity, physical activity, nutrition, and sleep contribute so strongly to cardiovascular disease prevention that adherence to the LE8 suggestions could prevent up to 40% of cardiovascular deaths annually.

As therapies grow more sophisticated, Kanwar believes the future of advanced heart failure depends on systems designed to manage complexity, clinically, technologically, and emotionally, while keeping patients at the center of every decision.

Editors’ Note: Kanwar reports relevant disclosures with Abiomed and Abbott.

Greene SJ, Xu H, Chiswell K, et al. One-year outcomes in patients hospitalized for heart failure with reduced ejection fraction prescribed quadruple medical therapy at discharge. JAMA Cardiology. Published online January 28, 2026. doi:10.1001/jamacardio.2025.5339

Palaniappan LP, Allen NB, Almarzooq ZI, et al. 2026 heart disease and stroke statistics: A report of US and Global Data from the American Heart Association. Circulation. Published online January 21, 2026. doi:10.1161/cir.0000000000001412

Articles

Advanced heart failure management is increasingly shaped by rapid therapeutic innovation alongside escalating clinical complexity. Guideline-directed quadruple therapy improves postdischarge outcomes but adds substantial pill burden and requires intensified monitoring. Optimal results increasingly depend on specialized, integrated programs capable of timely escalation to temporary support, LVAD, or transplantation. Pulmonary hypertension and cardiac amyloidosis are expanding priorities, supported by structured diagnostics and trial access, especially for transthyretin targets. Psychosocial comorbidity, depression, and adherence barriers necessitate embedded social work and behavioral health, reinforcing patient-centered shared decision-making.

Manreet Kanwar, MD, outlines advances in heart failure care, rising medication complexity, and the need for integrated, patient-centered systems.

News

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Clinical

clinical page is a resource for content on every specialty, disease, and topic available on our medical news site.

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

Heart Failure

The HCPLive heart failure page is a resource for medical news and expert insights on HF. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for heart disease, reduced and preserved ejection fraction, and more.

Comprehensive, Multidisciplinary Care for Complex Cardiac Disease

Digestive health is entering a period of rapid transformation, with scientific discovery, biologic therapies, precision diagnostics, and multidisciplinary care models redefining how clinicians manage complex gastrointestinal disease.

Conditions once associated with frequent hospitalizations and surgery are increasingly controlled with targeted medications and earlier intervention. At the same time, rising prevalence of 

, colorectal cancer, and other chronic GI disorders has heightened the need for coordinated specialty care.

According to David Rubin, MD, Joseph B. Kirsner Professor of Medicine, chief of Gastroenterology, Hepatology and Nutrition, and director of the Inflammatory Bowel Disease Center at University of Chicago Medicine, meeting this demand requires both clinical depth and a deliberate strategy to expand access without diluting expertise.

Rubin explains that the Inflammatory Bowel Disease Center at UChicago Medicine has long been recognized as a national leader in complex IBD care, treating patients with ulcerative colitis and Crohn’s disease across the full disease spectrum, including individuals referred for refractory symptoms or complications. He emphasizes that the growth of advanced biologics and small-molecule therapies has dramatically improved patient outcomes, allowing many to avoid surgery and maintain durable remission.

Recent regulatory developments of note in GI include the US Food and Drug Administration approval of mirikizumab-mrkz (Omvoh) as a single-injection once-monthly maintenance regimen for adult patients with ulcerative colitis, an updated indication statement allowing the use of upadacitinib (Rinvoq) for patients with moderately to severely active IBD after they have received ≥ 1 approved systemic therapy in the event TNF blockers are clinically inadvisable, and a subcutaneous induction regimen of guselkumab (Tremfya) for the treatment of adults with moderately to severely active ulcerative colitis.

However, Rubin notes that this therapeutic expansion has also introduced greater complexity. With multiple mechanisms of action now available, selecting the right therapy requires careful phenotyping, understanding prior treatment response, and monitoring for side effects.

“In addition to [the rising prevalence of IBD], there are multiple new therapies that are available, and for clinicians taking care of patients with IBD and patients who have these conditions, it is very confusing which treatments to use and how to know what's the best approach to management,” Rubin said, describing UChicago Medicine’s longstanding excellence in providing comprehensive IBD care.

Beyond medication, Rubin highlights the value of integrated, multidisciplinary care, describing how UChicago Medicine gastroenterologists work closely with colorectal surgeons, radiologists, pathologists, dietitians, and mental health professionals to address both intestinal and extraintestinal manifestations of disease. For patients facing surgery, he says, seamless coordination between medical and surgical teams improves both short- and long-term outcomes.

“Good medicine is a team sport. We have to work together, and we recognize that it takes a lot of people who understand the different aspects of what we're trying to provide to do it the right way,” he said.

Rubin additionally describes how research remains central to the program’s mission, citing active participation in clinical trials evaluating next-generation biologics, novel immune targets, and emerging therapeutic pathways. Access to investigational therapies, he notes, offers patients options beyond standard-of-care treatment and reinforces the institution’s role in shaping national practice guidelines.

As demand grows, Rubin also points to the importance of thoughtful geographic expansion. Extending subspecialty expertise into community settings increases access while maintaining centralized oversight for the most complex cases. He stresses that preserving program identity and clinical standards during expansion is essential to sustaining outcomes and reputation.

He describes education and patient engagement as being equally critical, emphasizing that empowering patients to understand their disease, adhere to therapy, and recognize early signs of flare can reduce hospitalizations and improve quality of life. Structured follow-up and long-term monitoring, he adds, are key components of chronic disease management.

Looking ahead, Rubin believes the future of GI care will center on precision medicine using biomarkers, genomics, and predictive modeling to match patients with the most effective therapy earlier in their disease course. Even as science advances, he maintains that success depends on maintaining a cohesive, multidisciplinary framework capable of delivering highly specialized care at scale.

Editors’ Note: Rubin reports relevant disclosures with AbbVie, Abivax, Bristol Myers Squibb, Celltrion, Eli Lilly, Genentech/Roche, Janssen Pharmaceuticals, Johnson & Johnson, Merck & Co., Pfizer, Sanofi, Spyre Therapeutics, Takeda, and others.

Livingston R. FDA Approves Single-Dose Formulation of Mirikizumab-mrkz for Ulcerative Colitis. HCPLive. October 27, 2025. Accessed February 17, 2026. 

https://www.hcplive.com/view/fda-approves-single-dose-formulation-of-mirikizumab-mrkz-for-ulcerative-colitis

Brooks A. FDA Approves Updated Indication for Upadacitinib (Rinvoq) in IBD. HCPLive. October 13, 2025. Accessed February 17, 2026. 

https://www.hcplive.com/view/fda-approves-updated-indication-for-upadacitinib-rinvoq-in-ibd

Brooks A. FDA Approves Guselkumab (Tremfya) Subcutaneous Induction Regimen for Ulcerative Colitis. HCPLive. September 19, 2025. Accessed February 17, 2026. 

https://www.hcplive.com/view/fda-approves-guselkumab-tremfya-subcutaneous-induction-regimen-for-ulcerative-colitis 

Digestive care is being reshaped by expanding biologic and small-molecule options, precision diagnostics, and integrated multidisciplinary models, particularly in inflammatory bowel disease. New FDA actions include once-monthly single-injection mirikizumab maintenance for ulcerative colitis, an updated upadacitinib indication after ≥1 systemic therapy when TNF blockers are inadvisable, and a subcutaneous guselkumab induction regimen for ulcerative colitis. Therapeutic breadth improves remission and surgery avoidance but increases decision complexity, heightening the need for careful phenotyping, longitudinal monitoring, research access, and scalable specialty-care expansion.

David Rubin, MD, discusses rapid advances in IBD care, new therapies, multidisciplinary models, and the push toward precision GI medicine.

Gastroenterology

Gastroenterology condition center page is a comprehensive resource for clinical news and insights on digestive and GI conditions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for 

, IBS and IBD, Crohn's disease, and more.

Hepatology

Inflammatory Bowel Disease

On the HCPLive inflammatory bowel disease page, resources on the topics of medical news and expert insight into IBD can be found. Content includes articles, interviews, videos, podcasts, and breaking news on IBD and more.

Expanding Clinical Reach in GI and Hepatology While Preserving Standards of Care

Gregg Pressman, MD, is a professor of medicine in the division of cardiology, Jefferson Einstein Philadelphia Hospital, Thomas Jefferson University.

Low-Grade Diastolic Dysfunction Still Harms Left Ventricle Function, With Gregg Pressman, MD

Right ventricular end-diastolic volume and right ventricular ejection fraction (RVEF) have been heavily associated with left ventricular diastolic function, with even grade 1 

 associated with a substantial drop in RVEF.

Left heart failure (HF) has long been known to be a common cause of right HF. Increases in left atrial pressure result in reduced pulmonary artery compliance and increased right ventricular afterload, and left ventricular diastolic function is a critical determinant of left atrial pressure. Given this connection, DD was widely expected to affect right ventricle size and function.

“We know that, when the left ventricle becomes stiff and a patient develops heart failure, the pressure of the heart rises, the pressure in the lungs rise, and the right ventricle can be enlarged and weakened,” Gregg Pressman, MD, professor of medicine in the division of cardiology, Jefferson Einstein Philadelphia Hospital, Thomas Jefferson University, told 

 in an exclusive interview. “What is less clear, and what we studied, is whether stiffening of the left side of the heart by itself causes abnormal function on the right half of the heart, even if the patient doesn’t have clinical signs and symptoms of heart failure.”

Pressman and colleagues enrolled 370 patients in the trial, all of whom were undergoing clinically indicated echocardiograms and had a 3D assessment of the right ventricle. Inpatients and outpatients were included; patients were excluded if they were younger than 18 years, had nongroup 2 

 by World Health Organization classification, nonsinus rhythm at the time of echocardiography, or suboptimal 3D echocardiographic images.

After imaging, patients were separated into groups based on diastolic function grade. The final data were based on the 2025 ASE algorithm, categorizing patients as having normal diastolic function or grades 1, 2, or 3 DD. Investigators compared 3D-derived right ventricle end-diastolic volume (RVEDV) and indexed RVEDV (RVEDVi) across diastolic grades, followed by comparing linear measurements of the right ventricle and the ratios of basal right ventricle diastolic dimension, mid-right ventricle diastolic dimension, and right ventricle diastolic longitudinal dimension.

A regression analysis was then conducted to determine whether diastolic grade was an independent predictor of RVEDV and RVEF, controlling for age, sex, race, body surface area, and estimated systolic pulmonary artery pressure.

Ultimately, for 21 subjects, the auto right ventricle software could not provide volumetric measurements. For another 22, it could not provide TAPSE or right ventricle linear dimensions. For the remainder, RVEDV and RVEDVi were similar between patients with normal diastolic function and grade 1 DD. However, grades 2 and 3 showed substantial increases in both measures of right ventricle diastolic size. Similarly, basal and midcavity dimensions were similar between normal and grade 1 DD, but increased for grade 2 and 3. However, longitudinal dimension showed no significant relationship with diastolic function grade.

RVEF also showed a substantial decrease across diastolic function groups, irrespective of age, sex, race, body surface area, and systolic pulmonary arterial pressure. Notably, even grade 1 DD showed a significant decrease in RVEF compared to normal; indexed left and right atrial volumes were similar, but reservoir strain of each atrium was decreased in patients with grade 1 DD.

Ultimately, Pressman and colleagues determined that left ventricular DD can produce right ventricular enlargement and cause right heart dysfunction. They attribute this in part to the backward effects of elevated left arterial pressure on the pulmonary vasculature, which are transmitted to the right heart. The trial also highlights the risk of even lesser degrees of left ventricular DD to the right heart.

“Right now, we’re at an interesting time in cardiology – this type of heart failure, which is due to stiffening, finally has some effective treatments,” Pressman said. “For years, we did not have such treatments, and it’s an open question whether applying those treatments to patients who have stiffening but have not yet developed clinical heart failure might prevent enlargement and weakening of the right half of the heart.”

Editor’s Note: Pressman reports no relevant disclosures.

Almani MU, Romero AJ, Akuna E, et al. Impact of left ventricular diastolic function on right ventricular size and function. 

Thomas L, Marwick TH, Popescu BA, Donal E, Badano LP. Left Atrial Structure and Function, and Left Ventricular Diastolic Dysfunction: JACC State-of-the-Art Review. 

Videos

Pressman discusses his recent study highlighting the interplay between right ventricular end-diastolic volume and ejection fraction and the left ventricle’s health.

Structural Heart Disease

Strategic Alliance Partnership

Fernando Magro, MD, PhD, is head of clinical pharmacology at University Hospital São João.

From Induction to Year 4: Mirikizumab’s Lasting Impact in Ulcerative Colitis

Long-term findings from the LUCENT clinical program continue to strengthen the case for mirikizumab (Omvoh) as a potential disease-modifying therapy in moderately-to-severely active ulcerative colitis (UC).

Data presented at the 21st Congress of European Crohn’s and Colitis Congress (ECCO) demonstrate the p19-directed interleukin (IL)-23 monoclonal antibody’s sustained efficacy and safety through 212 weeks of continuous treatment across the LUCENT-1 (induction), LUCENT-2 (maintenance), and LUCENT-3 (open-label extension) trials.

Mirikizumab was approved for the treatment of UC in 2023 based on LUCENT program data from a pair of trials, UC-1 , a 12-week induction study, and UC-2, a 40-week maintenance study. Most recently, the US Food and Drug Administration approved a single-injection, once-monthly maintenance regimen (200 mg/2 mL) of mirikizumab for subcutaneous use in adults with UC after demonstrating bioequivalence to the previously approved 2-injection regimen.

Study investigator Fernando Magro, MD, PhD, head of clinical pharmacology at University Hospital São João, noted that the LUCENT program’s design mirrors the real-world management of UC, allowing investigators to evaluate not only early response but durability and impact on hard clinical outcomes.

Preventing UC-related hospitalizations and surgeries is a key goal outlined in SPIRIT consensus recommendations for disease-modification trials. During LUCENT-1, patients randomized to intravenous mirikizumab 300 mg every 4 weeks demonstrated lower rates of UC-related hospitalizations and surgeries compared with placebo. Those who achieved clinical response at week 12 and continued on subcutaneous mirikizumab 200 mg every 4 weeks in LUCENT-2 maintained those reductions, with no UC-related hospitalizations or surgeries reported in the mirikizumab-treated group during maintenance.

Of note, the durability of benefit extended into LUCENT-3. Among 316 patients entering the open-label extension, representing 835 patient-years of exposure, a single UC-related hospitalization was reported over 3 years, corresponding to an exposure-adjusted incidence rate of 0.1 per 100 patient-years. No UC-related surgeries were observed. Taken together, Magro says these results suggest sustained suppression of disease activity over 4 years of continuous treatment.

“It is amazing that we are changing the outcome and the natural history of ulcerative colitis with mirikizumab,” he said.

Magro additionally emphasized that early achievement of endoscopic and histo-endoscopic mucosal improvement after induction was closely linked to improved 1-year outcomes. Patients who reached remission at 1 year experienced stability over time, with no reported hospitalizations or surgeries through 4 years. Such durability, Magro noted, signals more than short-term symptom control—it suggests modification of the disease course itself.

The concept of “disease clearance,” encompassing endoscopic remission, histologic remission, and absence of symptoms, further underscores this shift, with roughly 60% of patients achieving this deep remission at 1 year and many maintaining it long term.

Given the significant morbidity associated with colectomy and the profound impact hospitalizations and surgery have on quality of life, Magro says sustained reductions in these outcomes represent a meaningful advance.

Editors’ note: Magro reports relevant disclosures with Abbvie, Arena, Biogen, Bristol-Myers Squibb, Falk, Ferring, Hospira, Janssen, Laboratórios Vitoria, Pfizer, Lilly, Merck Sharp & Dohme, Sandoz, Takeda, UCB, and Vifor.

Magro F, Ananthakrishnan A, Kobayashi T, et al. Mirikizumab treatment decreases Ulcerative Colitis-related surgery and hospitalisation rates: 4-year LUCENT studies results. Presented at 21st Congress of European Crohn’s and Colitis Congress (ECCO), February 18–21, 2026, Stockholm, Sweden.

Campbell P. FDA Approves Mirikizumab (Omvoh) for Ulcerative Colitis. HCPLive. October 26, 2023. Accessed February 26, 2026. 

https://www.hcplive.com/view/fda-approves-mirikizumab-omvoh-for-ulcerative-colitis

Livingston R. FDA Approves Single-Dose Formulation of Mirikizumab-mrkz for Ulcerative Colitis. HCPLive. October 27, 2025. Accessed February 26, 2026. 

4-year LUCENT data show mirikizumab reduces UC-related hospitalizations and surgeries, supporting durable remission and potential disease modification.

Ulcerative Colitis

Ulcerative Colitis condition center page, resources on the topics of medical news and expert insight into colitis can be found. Content includes articles, interviews, videos, podcasts, and breaking news on UC research, treatment, and drug development.

LUCENT: Durable UC Control With Mirikizumab Through 4 Years, With Fernando Magro, MD, PhD

Discussing Promising New Findings on GLP-1 Use in Psoriasis Management

Discussing Promising New Findings on GLP-1 Use in Psoriasis Management, With Neal Bhatia, MD

 and obesity or overweight saw significant improvements in both conditions after using combined ixekizumab (Taltz) and tirzepatide (Zepbound) when compared to those using ixekizumab alone, according to recent data.

release of these data by Eli Lilly and Company

, resulting from the phase 3b TOGETHER-PsO trial (NCT06588283), the 

 editorial team interviewed Neal Bhatia, MD, the director of Clinical Dermatology at Therapeutics Clinical Research, to discuss these new data and their significance for weight loss and psoriasis.

“Mechanistically, it makes a lot of sense when you see what GLP-1 agonists do under the hood, with the immune mechanisms,” Bhatia said. “There's a lot of impact on [nuclear factor kappa B] as a neurotransmitter. Both interleukin 1 and interleukin 17 pathways are actually inhibited, or at least modulated, by their impact. Tumor necrosis factor…is suppressed just by trazepatide alone. Then you add just the active ingredient of what ixekizumab does as an IL-17 inhibitor.”

Bhatia touched on both the impacts of these 2 drugs in the open-label TOGETHER-PsO trial, highlighting their combined effects on skin clearance and weight loss in patients with psoriasis and elevated body mass index (BMI). He explained the synergistic impact of GLP-1 agonists on immune pathways, including NF-κB, interleukin (IL)-1, and tumor necrosis factor.

The investigators for TOGETHER-PsO had highlighted 27.1% of patients on the combination therapy achieved both PASI 100 and a minimum of 10% reduction in their weight, as opposed to only 5.8% of individuals treated with ixekizumab alone (

 Additionally, they had highlighted 40.6% of those in the combination arm achieved PASI 100 versus 29.0% in the monotherapy arm (

“[There are] a lot of opportunities to improve these patients along,” Bhatia explained. “Now, these are at 36 weeks, so this is a marathon, not a sprint, even though these drugs all work very fast.”

Bhatia noted future research on tirzepatide alone and its potential benefits in other diseases like hidradenitis suppurativa could be worth exploring. He also stressed the value of dermatologists and other clinicians integrating metabolic management into their practice to improve patient outcomes.

The quotes used in this summary were edited for the purposes of clarity.

Bhatia has reported serving as an advisor, consultant, and investigator for AbbVie, Almirall, Arcutis Biotherapeutics, Beiersdorf, Biofrontera, Boehringer Ingelheim, Bristol Myers Squibb, Cara Therapeutics, Dermavant Sciences, EPI Health, Ferndale, Galderma, Incyte, ISDIN, Johnson & Johnson, La Roche-Posay, LEO Pharma, Lilly, Ortho Dermatologics, Pfizer, Regeneron Pharmaceuticals, Sanofi, Sun Pharma, and Verrica Pharmaceuticals.

Lilly's Taltz (ixekizumab) and Zepbound (tirzepatide) used together delivered superior efficacy in first-of-its-kind Phase 3b trial for adults with psoriasis and obesity or overweight. Eli Lilly. February 18, 2026. Accessed February 26, 2026. 

https://investor.lilly.com/news-releases/news-release-details/lillys-taltz-ixekizumab-and-zepbound-tirzepatide-used-together-0

Smith T. Ixekizumab, Tirzepatide Effective Together for Psoriasis and Obesity or Overweight. HCPLive. February 18, 2026. Accessed February 26, 2026. 

https://www.hcplive.com/view/ixekizumab-tirzepatide-effective-together-psoriasis-obesity-overweight

In this interview, Neal Bhatia, MD, highlights several key points about treating psoriasis and obesity via ixekizumab and tirzepatide.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

Ryan Livingston joined the MJH Life Sciences team in March of 2025, shortly after graduating from TCNJ with a bachelor’s degree in English. He enjoys creative writing, reading, and scuba diving. He can be reached at rlivingston@mjhlifesciences.com.

Parent company Eli Lilly has released full data from ACHIEVE-3, indicating superior weight loss and A1C reductions with orforglipron 12 mg and 36 mg.

Endocrinology

The HCPLive endocrinology page is a comprehensive resource for clinical news and insights on endocrine system conditions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for diabetes, hormonal disease, and more.

Type 2 Diabetes

ACHIEVE-3: Orforglipron Achieves Superiority to Oral Semaglutide in Poorly Controlled T2D

The supplemental New Drug Application submission comes as a result of positive phase 3 data from the CORE and CORE2 trials or olezarsen in 2025.

Dyslipidemia

FDA News

FDA Accepts Olezarsen’s sNDA for Severe Hypertriglyceridemia, Grants Priority Review

Muthiah Vaduganathan, MD, MPH, is a cardiologist specializing in cardiorenal metabolism at Brigham and Women's Hospital in Boston, MA. Vaduganathan is a member of Practical Cardiology's advisory board and co-host of Don't Miss a Beat, a podcast presented by Inside Cardiology.

Why CKD screening lags despite aligned KDIGO, ADA and hypertension guidance—use eGFR plus UACR staging and EHR prompts to act earlier.

Video Series

Understanding the Link Between Early CKD Diagnosis and Cardiovascular Outcomes

CKD guidelines agree: use eGFR plus UACR for KDIGO staging, but screening lags—see how teams and EHRs close the gap.

Quality of Life Impact of Delayed CKD 

Timothy E. Dribin, from the division of emergency medicine, at Cincinnati Children’s Hospital Medical Center.

Expert panel identifies high agreement for multi-organ involvement, but uncertainty remains in moderate isolated skin or mucosal symptoms.

Anaphylaxis

The HCPLive anaphylaxis page is a comprehensive resource for clinical news and insights on acute allergic reactions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for preventing anaphylaxis, and more.

Allergy

Allergy condition center page is a comprehensive resource for clinical news and insights on allergic and inflammatory diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for food and seasonal allergies, as well as allergic asthma and related conditions.

International Consensus on Epinephrine Use, With Timothy E. Dribin, MD

Victoria Johnson joined the MJH Life Sciences in 2020 and has written for NeurologyLive, CGTLive, and now HCPLive. You can reach her at vjohnson@mjhlifesciences.com

Claims study suggests dry powder and soft mist COPD inhalers cut exacerbations versus MDIs, offering greener care without added safety risks.

COPD

COPD condition center page, resources on the topics of medical news and expert insight into chronic obstructive pulmonary disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on COPD research, treatment, and drug development.

Pulmonology

Infectious Disease condition center page is a comprehensive resource for clinical news and insights on respiratory health. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for asthma, COPD, interstitial lung disease, COVID-19, and more.

Lower-Carbon LAMA–LABA Inhalers Linked to Modest Reductions in COPD Exacerbation Risk

Joshua Rothman, MD, MS, is a clinical assistant professor in the department of pediatrics and Medical Director of Informatics Academic Pediatrics at the University of California San Diego.

New data show a >10% drop in newborn hepatitis B vaccination, raising concern for rising chronic infection and future liver cancer risk.

Hepatitis C

Hepatitis C page, resources on the topics of medical news and expert insight into HCV can be found. Content includes articles, interviews, videos, podcasts, and breaking news on hepatitis C virus research, treatment, and drug development.

Declining Hepatitis B Birth Dose Rates and the Risk to Long-Term Liver Health, With Joshua Rothman, MD, MS

This February episode of The Medical Sisterhood highlights key points on juggling work as a clinician and work as a mother.

The Medical Sisterhood, with Mona Shahriari, MD

The Medical Sisterhood, hosted by Mona Shahriari, MD, is a podcast dedicated to empowering female physicians by providing a platform for shared experiences, mentorship, and support. 

Each episode delves into the unique challenges women in medicine face, including work-life balance, leadership roles, and overcoming gender biases. Shahriari aims to inspire women to lead fulfilling professional and personal lives on their own terms through candid discussions and expert interviews. 

e as we foster a community where women can uplift and support each other in achieving their goals!

Dermatology

The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

The Medical Sisterhood: Physician Mom Burnout & Mental Health Strategies, With Jennifer Hsiao, MD

The FDA has approved proprietary desmopressin oral solution formulation ET-600 for the treatment of central diabetes insipidus in children.

FDA Approves ET-600 Desmopressin Acetate (Desmoda) for Central Diabetes Insipidus

Mary K Roberts, PhD is a Post Doctoral Researcher at the Leverhulme Centre for Demographic Science at the University of Oxford.

Willingness to pursue living kidney donation is shaped by relationships, health, and a multidisciplinary approach, not just finances.

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

Latest News

Comprehensive, Multidisciplinary Care for Complex Cardiac Disease

Expanding Clinical Reach in GI and Hepatology While Preserving Standards of Care

Low-Grade Diastolic Dysfunction Still Harms Left Ventricle Function, With Gregg Pressman, MD

LUCENT: Durable UC Control With Mirikizumab Through 4 Years, With Fernando Magro, MD, PhD

Discussing Promising New Findings on GLP-1 Use in Psoriasis Management, With Neal Bhatia, MD