Patricia Fechner, MD, is the attending physician at Seattle Children’s Hospital and a professor of pediatrics at the University of Washington School of Medicine.

Crinecerfont Maintains Improvements in Pediatric CAH at 2 Years, With Patricia Fechner, MD

 treated with crinecerfont have shown lower glucocorticoid doses and reduced symptoms, according to 2-year data from the CAHtalyst Pediatric study.

“I think we are approaching a true tradeoff now,” Patricia Fechner, MD, attending physician at Seattle Children’s Hospital and a professor of pediatrics at the University of Washington School of Medicine, told 

 in an exclusive interview. “We no longer need to dose our glucocorticoids for treatment of CAH to suppress the adrenal androgens and to replace the adrenal insufficiency – we can separate those 2 mechanisms and just give the glucocorticoid dosing for adrenal insufficiency and then give the crinecerfont to maintain lower doses of adrenal androgens.”

The CAHtalyst Pediatric study is a randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of crinecerfont in children. It was conducted across 46 locations worldwide and included patients with a medically confirmed diagnosis of classic CAH due to 21-hydroxylase deficiency who were on a stable steroid regimen and had elevated androgen levels. Patients with any other forms of classic CAH, a history of bilateral adrenalectomy, hypopituitarism, or other conditions needed chronic glucocorticoid therapy, or a history of cancer, among other criteria, were excluded.

Patients were randomly assigned in a 2:1 ratio to receive either crinecerfont as a solution or capsule, administered orally twice daily for 28 weeks or matching placebo. A stable glucocorticoid dose was maintained for 4 weeks, followed by an adjustment to 8 to 10 mg per square meter of body surface area per day, so long as androstenedione levels were controlled. Following the initial 28-week period, the placebo patients crossed over to crinecerfont for ≥24 weeks.

The primary outcome was change from baseline in serum androstenedione at week 4, measured via blood serum samples. Secondary outcomes included change in serum 17-hydroxyprogesterone at week 4, percent change in glucocorticoid daily dose at week 28, and change from baseline in the ratio of bone age to chronological age at week 28.

A total of 103 patients were randomized – 69 were assigned to crinecerfont and 34 to placebo. Of these, 100 (97%) remained in the trial at 28 weeks. The mean glucocorticoid dose at baseline was 16.4 mg per square meter per day, and the mean androstenedione level was 15 nmol/L. By week 4, investigators noted substantially reduced androstenedione in the crinecerfont group (-6.9 nmol/L) and a concurrent increase in the placebo group (2.5 nmol/L). By week 28, mean glucocorticoid had decreased by 18% with crinecerfont but increased by 5.6% in the placebo arm.

The present 2-year data follow these trends, with patients continuing to experience significant reductions in adrenocorticotropic hormone and 17-hydroxyprogesterone while achieving lower glucocorticoid doses. The analysis included 86 patients who had completed 2 years of treatment in the open-label extension period. Meaningful reductions were observed across hormone control, excess androgens, and long-term supraphysiologic glucocorticoid exposure – in addition, treatment was well-tolerated, with >80% study retention by 2 years and no new safety signals.

“This is the first new medication in over 70 years,” Fechner said. “It has changed how we treat CAH, and I think families wanted to be in the study. It was well tolerated, and patients’ parents were able to see the results of improvement in growth, their management of CAH, and the decrease in hydrocortisone dosing that their children needed.”

Editors’ Note: Fechner reports disclosures with Neurocrine Biosciences, Spruce Biosciences, and Neurocrine Ltd.

Neurocrine Biosciences. Neurocrine Biosciences Presents New Two-Year CRENISSITY (crinecerfont) Data Demonstrating Durable Hormone Control, Reduced Glucocorticoid Exposure and Meaningful Clinical Improvements in Pediatric Patients with Classic Congenital Adrenal Hyperplasia. 

https://www.prnewswire.com/news-releases/neurocrine-biosciences-presents-new-two-year-crenessity-crinecerfont-data-demonstrating-durable-hormone-control-reduced-glucocorticoid-exposure-and-meaningful-clinical-improvements-in-pediatric-patients-with-classic-congenital-302759774.html

Neurocrine Biosciences. Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study). ClinicalTrials.gov Identifier: NCT04806451. Updated February 5, 2025. Accessed May 15, 2026. 

https://clinicaltrials.gov/study/NCT04806451

Sarafoglou K, Kim MS, Lodish M, et al. Phase 3 trial of Crinecerfont in pediatric congenital adrenal hyperplasia. New England Journal of Medicine. 2024;391(6):493-503. 

Videos

Fechner discusses the 2-year data from an open-label extension of the CAHtalyst Pediatric study, maintaining substantial glucocorticoid dose lowering.

News

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This page also hosts content previously published by EndocrinologyNetwork. 


Hormonal Disorders

Welcome to The HCPFive, your go-to roundup for the latest healthcare news and breakthroughs, curated specifically for busy healthcare professionals.

Each week, we highlight 5 key developments or headlines from healthcare that you need to know — whether it's a cutting-edge treatment, regulatory updates, or innovations shaping the future of medicine. This week's top stories include FDA submissions for mitapivat in sickle cell disease and encaleret in autosomal dominant hypocalcemia type 1 (ADH1), the resignation of FDA Commissioner Marty Makary, MD, MPH, the FDA clearance of the EndoTool IV Cloud, and new American Heart Association guidelines for optimizing postpartum heart health in women.

With The HCPFive, you'll get the essential takeaways to stay informed and ahead of the curve. Here's your quick dive into the top stories for the week of May 10, 2026 — let's jump in!

Mitapivat sNDA Seeks FDA Accelerated Approval in Sickle Cell Disease

On May 12, 2026, Agios submitted a Supplemental New Drug Application (sNDA) to the FDA seeking accelerated approval of mitapivat for sickle cell disease. The filing, which was supported by data from the RISE UP phase 2 and phase 3 programs, places the oral pyruvate kinase activator under FDA review for a potential new hematology indication after prior approvals in other rare hemolytic anemias.

BridgeBio Submits NDA for Encaleret for Autosomal Dominant Hypocalcemia Type 1

On May 12, 2026, BridgeBio submitted a NDA for encaleret to the FDA for patients with ADH1. The submission follows positive results from the CALIBRATE phase 3 trial, in which encaleret achieved all pre-specified primary and key secondary efficacy endpoints. The company is currently enrolling patients in CALIBRATE-PEDS, a global registrational phase 2/3 study of encaleret in pediatric ADH1.

FDA Commissioner Marty Makary Resigns, Kyle Diamantas Steps In as Acting Head

On May 12, 2026, FDA Commissioner Marty Makary, MD, MPH, resigned from his position following weeks of reports that the Trump administration was planning his removal. Kyle Diamantas, JD, the Agency's Deputy Commissioner for Food, has been named acting commissioner while a permanent replacement is identified. The resignation marks one of the fastest commissioner departures in modern FDA history. Makary served in the role for just over a year, having been confirmed on March 25, 2025, by a bipartisan vote of the US Senate as the 27th Commissioner of Food and Drugs.

FDA Clears EndoTool IV Cloud for Inpatient IV Insulin Dosing Support

On May 14, 2026, the FDA cleared the EndoTool IV Cloud, a cloud-based version of parent company Glooko’s inpatient intravenous insulin dosing decision-support platform, through the 510(k) pathway. According to the company, the newly cleared product uses the same insulin-dosing algorithm as the existing EndoTool IV system and is expected to launch commercially in the US before the end of 2026.

New AHA Recommendations Encourage Improving Postpartum Cardiovascular Care

A recent publication from the American Heart Association has provided a set of guidelines and tools to optimize postpartum heart health for women. The recommendations aim to provide a pathway for evidence-based care implementation during the postpartum phase, which has been historically overlooked in its potential for cardiovascular risk.

The document is its second iteration following a secondary literature review and ongoing dialogue with clinical and community organizations. The recommendations are collected into 4 major points: standardizing postpartum systems, interdisciplinary care and engagement, advocacy and policy expansion, and risk factor identification and monitoring.

Articles

Regulatory activity included Agios’ sNDA seeking accelerated approval of the oral pyruvate kinase activator mitapivat for sickle cell disease, supported by RISE UP phase 2/3 data. BridgeBio filed an NDA for encaleret in autosomal dominant hypocalcemia type 1 after CALIBRATE met primary and key secondary endpoints, with CALIBRATE-PEDS enrolling. Leadership upheaval followed FDA Commissioner Marty Makary’s resignation; Kyle Diamantas became acting commissioner. The FDA also cleared Glooko’s EndoTool IV Cloud via 510(k). Updated AHA recommendations target standardized, interdisciplinary postpartum cardiovascular risk management.

Stay updated with the latest healthcare breakthroughs, including FDA submissions and new cardiology guidelines.

Hematology

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

The HCPFive: Top News for Healthcare Providers from the Week of 05/10

Barry A. Borlaug, MD is a cardiologist in Rochester, Minnesota, affiliated with the Mayo Clinic.

Updated HFmrEF Guidelines From HFSA Support Standard HFrEF Treatment

The Heart Failure Society of America (HFSA) has released a new scientific statement encouraging the acceptance of 

heart failure with mildly reduced ejection fraction (HFmrEF)

Prior to the statement’s release, HFmrEF has largely been considered a gray zone in between heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF), and as a result has been understudied. Initially identified by the European Society of Cardiology (ESC) in 2016 and termed heart failure with mid-range ejection fraction, clinical trials have historically overlooked this patient population, leading to limited available evidence.1,2

“There’s been a little confusion out there, especially in people who are outside of heart failure circles, as to who these patients are, whether they justify their own distinction, what we look for, how we treat them, et cetera,” Barry Borlaug, MD, associate professor of medicine at Mayo Clinic and co-author of the statement, told 

 in an exclusive interview. “That was really the basis for putting together this expert scientific statement.”

Borlaug and colleagues highlight shortcomings with current HF management and diagnosis, noting that although EF is typically used as a benchmark to differentiate between the major categories, it is an intrinsically imperfect measurement. EF is dependent on a variety of factors, including chamber size, which naturally decreases as chamber volume increases, as well as hemodynamic loading conditions.1

Given these limitations in standard disease identification, Borlaug and colleagues created a series of practical considerations for other clinicians, highlighting 5 major points in HFmrEF diagnosis, treatment, and management. These points include the following:

Recognition: Patients with symptoms of HF and EF 41-49% should be identified and followed

Classification: Careful imaging interpretation and consistent EF definitions are needed

Assessment: Evaluation should include structural abnormalities, ischemic burden, and comorbidities

Management: Utilize HFrEF guideline-directed therapies while acknowledging current evidence limitations

Follow-up: Periodic reassessment to account for gradual EF change2

Borlaug and colleagues also created a slide deck containing the top 10 take-home messages from the document, which were drafted as a quick reference guide.

HFmrEF is common - affecting 1 in 4 HF patients - and treatment should mirror GDMT for HFrEF

HFmrEF resembles HFrEF more closely than HFpEF, with high rates of ischemic heart disease, atrial fibrillation, and diabetes

Some studies show ejection fraction as dynamic, emphasizing the need for longitudinal monitoring

Patients with EF 41-49% and symptoms of HF should be followed as having HFmrEF

SGLT2 inhibitors demonstrate benefit across the EF spectrum, including HFmrEF, with a substantial reduction in HF hospitalization or cardiovascular death

GDMT for HFrEF is appropriate for HFmrEF, including beta-blockers, ARNI/ACEi/ARB, and MRAs

Ischemic heart disease is common and prognostically important in HFmrEF - evaluation for ischemia and revascularization consideration may alter EF trajectory outcomes

EF alone is an imperfect measure for myocardial function

Phenotype-specific approaches matter - obesity-related HFmrEF may benefit from GLP-1 RAs

HFmrEF is understudied and under-recognized - dedicated trials are needed to advance the evidence base

Current evidence, according to the team, indicates that HFmrEF is a heterogeneous group, including patients with clinical features indicating HFrEF and others more closely aligned with HFpEF. The most effective treatment options based on existing data are SGLT2 inhibitors, with MRAs, ARBs, beta-blockers, and combined ARB/neprilysin inhibitors showing evidence from subgroup analyses. Borlaug and colleagues determined that treatment with guideline-directed medical therapy for HFrEF is the most reasonable course of action.

“The guidelines haven’t given class 1 indications because there haven’t been specific trials, but I think all of us really feel like these people should be treated just like HFrEF,” Borlaug said. “I think that would be the main takeaway – recognize that it is true, legitimate heart failure, and for the most part, treat these patients as though they have HFrEF, with the pillars that we use in that form of heart failure.”

Editors’ Note: Borlaug reports disclosures with AstraZeneca, Cytokinetics, Merck, Novo Nordisk, Tectronic Therapeutics, BridgeBio Pharmacy, and others.

WILCOX JE, LUND LH, COX ZL, et al. Heart failure with mildly reduced ejection fraction: A Heart Failure Society of America scientific statement. Journal of Cardiac Failure. Published online April 22, 2026. 

Heart Failure Society of America. New HFSA Scientific Statement Provides Practical Guidance for Managing Heart Failure with Mildly Reduced Ejection Fraction. April 22, 2026. Accessed May 15, 2026. 

https://hfsa.org/new-hfsa-scientific-statement-provides-practical-guidance-managing-heart-failure-mildly-reduced

Barry Borlaug, MD, discusses his recent publication collecting existing evidence on HFmrEF to reflect current data regarding treatment and management.

Heart Failure

The HCPLive heart failure page is a resource for medical news and expert insights on HF. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for heart disease, reduced and preserved ejection fraction, and more.

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

Approximately two-thirds of individuals with 

 and prurigo nodules (AD-PN) attained significant reduction in itch within 12 weeks of initiating upadacitinib in real-world clinical settings, recent data suggest.

This analysis was authored in Japan and led by such investigators as Hiroyuki Murota, MD, PhD, from the Nagasaki University Graduate School of Biomedical Sciences’ Department of Dermatology. Murota and colleagues’ research was previously released during the 2026 American Academy of Dermatology (AAD) Annual Meeting in Denver, Colorado.

“The efficacy and safety of [targeted immune modulators], including upadacitinib, have been demonstrated in patients with prurigo nodularis, but those in patients with AD-PN are limited,” Murota and coauthors noted.

AD-PN was described by the investigators as one of the most treatment-resistant types of atopic dermatitis, with patients often facing multiple, widespread nodular skin lesions leading to intense levels of pruritus or itch. Upadacitinib, an oral Janus-kinase (JAK)1 inhibitor, is already approved for moderate-to-severe disease, but its use in the specific AD-PN subtype was not well established in real-world clinical settings prior to this analysis.

The ADMIRE study was designed by Murota et al to address that gap in Japan. ADMIRE was a non-interventional, multi-center, prospective observational analysis involving the enrollment of 120 individuals with moderate-to-severe AD-PN. These patients, located across Japan, were recruited between December 2022 - November 2023. They were followed over 48 weeks.

Murota and coauthors’ main endpoint was at least a 4-point reduction in the Worst Pruritus Numerical Rating Scale (WP-NRS) at the 12-week mark. It was determined to be a meaningful threshold suggesting significant relief from pruritus. In terms of secondary endpoints, the investigative team tracked a broad range of clinical and patient-reported outcomes over the entire 48-week period.

The 119 individuals included in the safety analysis were noted to have an average age of about 33, and 57% were labeled as male. At the point of baseline, those assessed showed a high level of disease burden: an average WP-NRS itch scores of 7.2 out of 10, a 46.3% mean level of body surface area involvement, and a significant level of quality-of-life impairment. Approximately 40% had previously implemented systemic agents, including dupilumab, cyclosporine, and other JAK inhibitors.

Overall, Murota and coauthors’ research achieved its primary endpoint, with 65.7% of those evaluated attaining a ≥4-point improvement in WP-NRS at the 12-week mark. Crucially, meaningful improvements were already visible as early as Week 4 across nearly all measures and continued to deepen through Week 48. The number of visible prurigo nodules dipped dramatically, from an average of 26 at the point of baseline to under 3 by the 48-week mark.

Skin clearance also improved substantially, with over 83% of those evaluated showing near-clear or clear nodule staging by Week 48. Additionally, skin pain scores similarly saw improvement, with the investigators highlighting the roughly 60% showing minimal or no pain at the 48-week mark. Quality of life, measured by the DLQI, also saw improvement, with about 39% of participants reporting no disease impact on daily life by Week 48.

Upadacitinib’s safety profile was consistent with what had been noted in prior phase 3 data. Murota et al noted 60% of those assessed experienced at least a single adverse event (AE), most commonly infections (37%), with nasopharyngitis, acne, and influenza being most frequent. Herpes zoster was seen in 5% of subjects. Notably, a lack of major cardiovascular events, venous thromboembolism, tuberculosis, or malignancy was observed.

ADMIRE provides real-world data suggesting upadacitinib may be an efficacious and well-tolerated oral agent among individuals dealing with the challenging AD-PN phenotype, with rapid and durable improvements in pruritus, skin clearance, and quality of life being highlighted primarily.

Notably, Murota et al found no “new safety signals were identified with the observed safety profile similar to that previously reported in phase 3 clinical trials and post-marketing clinical studies for upadacitinib.”

Editor’s note: These data were summarized with the help of AI tools.

Murota H, Hagino T, Tada Y, et al. A Prospective Study to Evaluate the Effectiveness of Upadacitinib in Moderate-to-Severe Atopic Dermatitis with Prurigo Nodules in the Real World in Japan: ADMIRE. Presented at the 2026 American Academy of Dermatology (AAD) Annual Meeting, March 27–31, 2026, Denver, CO, USA.


Upadacitinib demonstrated rapid, clinically meaningful pruritus control in moderate-to-severe atopic dermatitis with prurigo nodules in a Japanese prospective real-world cohort. In ADMIRE (n=120; 48-week follow-up), 65.7% achieved a ≥4-point WP-NRS reduction by Week 12, with improvements apparent by Week 4 and deepening through Week 48. Prurigo nodules markedly regressed (mean 26 to <3), skin clearance and pain improved, and DLQI gains were substantial. Safety was consistent with known profiles, dominated by infections.

Patients with atopic dermatitis and prurigo nodules (AD-PN) saw notable itch reduction in 12 weeks after initiating upadacitinib.

Atopic Dermatitis

Atopic Dermatitis condition center page, audiences can find a variety of coverage mediums for medical news and updates, including articles, video interviews, podcasts, and breaking news on dermatitis research, treatment, and drug development.

Dermatology

The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

ADMIRE: Upadacitinib Efficacious in Atopic Dermatitis with Prurigo Nodules

Marc Ruel, MD, MPH, is a professor and the endowed chair and director of minimally invasive cardiac research in the division of cardiac surgery at the University of Ottawa Heart Institute.

AHA Releases Updated Guidelines for Secondary Prevention Post-CABG

A new statement from the American Heart Association (AHA) has provided updated evidence and suggestions for coronary artery bypass grafting (CABG) and postoperative management in patients with 

The last guideline update published by the AHA on secondary prevention after CABG was in 2015. The document was constructed from 2 2011 AHA and American College of Cardiology Foundation (ACCF) documents, which summarized the use of medical therapy after coronary revascularization. The 2026 update follows over a decade of evidence collection and highlights significant progress in both pre- and postoperative disease management.

“Over the last 11 years, what we’ve seen is not only progress with regards to the type of surgery that we do, but how patients are cared for and the relative safety of the surgery,” Marc Ruel, MD, MPH, a professor and the endowed chair and director of minimally invasive cardiac research in the division of cardiac surgery at the University of Ottawa Heart Institute and co-author of the statement, told 

. “We know now that there are so many interacting factors that can make a patient derive a better outcome – not only with regards to preserving the patency of the grafts but also preventing more cardiometabolic disease or cerebral vascular disease or even coronary artery disease.”

The present document highlights several major areas of focus in postoperative CAD treatment, given that the disease continues to progress after CABG. Among these are lipid management, antithrombotic therapy, and antihypertensive therapy, as well as disease management for patients with diabetes.

 profiles, including high low-density lipoprotein cholesterol (LDL-C), low high-density lipoprotein cholesterol (HDL-C), or high triglyceride levels. Despite the use of high-intensity statins, many patients fail to attain lipid targets; additionally, LDL-C levels at 1 year following CABG are associated with long-term major adverse cardiovascular events (MACEs).

To address this, the document recommends an LDL-C threshold target of 55 mg/dL, with levels no higher than 70 mg/dL. Additionally, the authors suggest high-intensity or maximally tolerated statin therapy as a first-line therapy, with ezetimibe recommended for second-line and PCSK9 inhibitors or icosapent ethyl as third-line therapies.

Ruel and colleagues note that dual antiplatelet therapy (DAPT) and the addition of oral anticoagulants to antiplatelet therapy frequently increase bleeding risk following CABG. To this end, the document suggests initiating low-dose aspirin within 6 hours of CABG conclusion – this treatment effectively improves graft patency and reduces future cardiovascular events. However, higher doses can potentially increase gastrointestinal bleeding risk. Additionally, the authors suggest DAPT for 1 year following CABG in patients with acute coronary syndrome (ACS), given its association with a lower risk of death and cardiac events. While routine DAPT is not indicated in patients with chronic coronary disease, DAPT with aspirin and clopidogrel or ticagrelor can be considered to prevent graft failure in patients who are not at a high risk of bleeding.

The document implores clinicians to work for extremely strict blood pressure goals, given the activation of several neurohumoral and endogenous vasodilator systems early after CABG – in particular, Ruel and colleagues suggest a target of <130/<80 mmHg. Additionally, the document points out that ACE inhibitors and ARBs are indicated for patients with a clinical indication beyond CABG, including previous MI, diabetes, 

, reduced left ventricular ejection fraction, and 

. Calcium channel blockers are also recommended for the first postoperative year, along with dihydropyridines to help limit radial artery graft spasm.

Following CABG, the guidelines recommend that clinicians prioritize SGLT2 inhibitors for patients with diabetes regardless of baseline HbA1c, primarily for use in reducing MACEs and providing renal protection. Additionally, SGLT2 inhibitors should be utilized in patients with heart failure irrespective of diabetes status or ejection fraction. GLP-1 RAs are also flagged for prioritization in patients with diabetes or a body mass index (BMI) >27 kg/m2 to reduce MACEs.

Ultimately, these guidelines reflect 11 years of evidence collection in both CABG and follow-up therapy, bringing the field substantially further from the 2015 guidelines. However, Ruel and colleagues also acknowledge that further research must be conducted to optimize treatment for all patients both before and after the operation.

“Going forward, I think we can only go up from where we are,” Ruel said. “The 2015 statement helped achieve some strides in various jurisdictions. We’re not there yet, but we are making progress, and hopefully this statement helps.”

Editors’ Note: Ruel reports no relevant disclosures.

Ruel M, Sandner S, Ponnambalam M, et al. Secondary prevention after coronary artery bypass graft surgery: 2026 update: A scientific statement from the American Heart Association. Circulation. Published online May 13, 2026. 

Kulik A, Ruel M, Jneid H, et al. Secondary prevention after coronary artery bypass graft surgery. Circulation. 2015;131(10):927-964. 

Marc Ruel, MD, MPH, discusses the progress made since in the 11 years since the last guidelines, both in treatment and therapy.

Arrhythmia

Dyslipidemia

Venous Thromboembolism

The HCPLive venous thromboembolism page is a resource for medical news and expert insights on VTE. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for thrombotic disease, and more.

Hypertension

The HCPLive hypertension page is a resource for medical news and expert insights on high blood pressure. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for hypertension, and more.

Chelsie Derman is an associate editor for 

who covers allergy and  psychiatry. She joined MJH Life Sciences in September 2023 after graduating from The College of New Jersey with a bachelor’s degree in journalism and professional writing. In her free time, she enjoys creative writing and reading.

Transcranial magnetic stimulation for major depressive disorder is shifting toward accelerated (5x5 and SWIFT protocol) and at-home models (ProlivRx).

Psychiatry

Psychiatry condition center page is a comprehensive resource for clinical news and insights on mental illnesses. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for depression, schizophrenia, bipolar disorder, anxiety, and more.

Major Depressive Disorder

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TMS for MDD Reimagined: Faster, Fewer Visits, and Now at Home

On IgAN Awareness Day, clinicians highlight earlier diagnosis, dynamic risk stratification, and emerging targeted therapies reshaping care.

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

IgA Nephropathy

The HCPLive Berger disease page is a resource for medical news and expert insights on IgA nephropathy. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in Berger disease, and more.

Strategic Alliance Partnership

IgAN Enters “Mechanism-First Era” Reframing Diagnosis, Treatment, and Remission

Podcasts

In this May episode of The Medical Sisterhood podcast, the show features guest Lisa Swanson, MD, discussing the emotional realities of pediatric dermatology.

podcasts page features a feed of medical news and interview podcast series, including DocTalk, Lungcast, Derm Discussions, and Heart Trials.

The Medical Sisterhood, with Mona Shahriari, MD

The Medical Sisterhood, hosted by Mona Shahriari, MD, is a podcast dedicated to empowering female physicians by providing a platform for shared experiences, mentorship, and support. 

Each episode delves into the unique challenges women in medicine face, including work-life balance, leadership roles, and overcoming gender biases. Shahriari aims to inspire women to lead fulfilling professional and personal lives on their own terms through candid discussions and expert interviews. 

e as we foster a community where women can uplift and support each other in achieving their goals!

The Medical Sisterhood: The Hidden Cost of Being the Compassionate Doctor, With Lisa Swanson MD

See how coronary calcium images and risk graphs boost engagement, drive LDL-lowering choices, and help more patients reach cholesterol goals.

Optimizing ASCVD Prevention Through Combination Therapy and Managing Statin Intolerance

Bruce Strober, MD, PhD, introduces a practical framework for determining when differences in efficacy between psoriasis treatments are clinically meaningful.

Risankizumab vs Icotrokinra for Psoriasis 

Bruce Strober, MD, PhD, compares agents within the IL-23 inhibitor class on dosing schedule and joint outcome data, and explains why long-term drug survival has become a central consideration in biologic selection for psoriasis.

Comparing IL-23 Inhibitors — Dosing Intervals, Radiographic Data, and Long-Term Drug Survival

Driving Patient Engagement in ASCVD

Treatment-associated phenotype switching between psoriasis and atopic dermatitis was noted to be reproducible and bidirectional in real-world clinical settings.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

Psoriasis-Atopic Dermatitis Phenotype Switching: New Real-World Data

Payam Dehghani, MD, is an associate professor of cardiology at the University of Saskatchewan and co-founder of Prairie Vascular Research, Inc.

Payam Dehghani, MD, discusses his sub-study of the NACMI registry, following patients with COVID-19 and STEMI who survived to hospital discharge.

COVID-19 Amplifies 1-Year STEMI Mortality Following Hospitalization

Physician and CEO, Chicago Allergy Center, and board director at American Lung Association

Drs. Vin Gupta and Juanita Mora discuss the recent report and how it should inform clinician actions.

Pulmonology

Infectious Disease condition center page is a comprehensive resource for clinical news and insights on respiratory health. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for asthma, COPD, interstitial lung disease, COVID-19, and more.

Latest News

Crinecerfont Maintains Improvements in Pediatric CAH at 2 Years, With Patricia Fechner, MD

The HCPFive: Top News for Healthcare Providers from the Week of 05/10

Updated HFmrEF Guidelines From HFSA Support Standard HFrEF Treatment

ADMIRE: Upadacitinib Efficacious in Atopic Dermatitis with Prurigo Nodules

AHA Releases Updated Guidelines for Secondary Prevention Post-CABG