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Genetic variants tied to CAR T toxicity and expansion could guide how researchers screen healthy donors for allogeneic CAR T products.

Selecting Donor T Cells for CAR T Therapy, With Mark B. Leick, MD

Germline STXBP2 variants may predict severe CAR T cell toxicity, Mark B. Leick, MD, and colleagues find

A Genetic Signature May Predict Who Gets Sick From CAR T Cell Therapy

New research links germline genetic variants to CAR T cell toxicity risk and expansion in lymphoma patients treated with axi-cel.

Germline Variants May Predict CAR T Cell Toxicity, With Mark Leick, MD

Hematology in July 2026: FDA priority review for Agios' mitapivat in sickle cell disease, plus Orca-T's approval for GVHD-free survival.

3 Hematology Headlines You Missed in July 2026

Stacey Rifkin-Zenenberg, DO, on gene therapy vs stem cell transplant and when to refer for sickle cell disease. 

With 2 Curative Pathways, Sickle Cell Intervention Can Start in Infancy

Stay updated with the latest healthcare breakthroughs, including phase 3 plozasiran data in hypertriglyceridemia and the FDA approval of Furoscix ReadyFlow.

The HCPFive: Top News for Healthcare Providers from the Week of 07/26

Stay updated with the latest healthcare breakthroughs, including phase 3 plozasiran data in hypertriglyceridemia, the FDA approval of Furoscix ReadyFlow, and more.

The HCPFive: Top News for Healthcare Providers from the Week of 07/19

Exa-cel requires careful counseling on treatment timelines, chemotherapy conditioning, fertility risks, and the gene therapy journey.

Counseling Patients On Exa-cel Gene Therapy Journey, With Haydar Frangoul, MD, MS

Agios ends tebapivat development in sickle cell disease after phase 2 results show no differentiated benefit.

Agios Ends Tebapivat Development in Sickle Cell Disease After Phase 2

Haydar Frangoul, MD, discusses how the expanded indication may allow earlier conversations about curative therapy and intervention before irreversible complications develop.

FDA Expands Exa-Cel (Casgevy) Approval, Bringing Gene Therapy to Younger Children

Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria Condition Center page, visitors can find resources on the topics of medical news and expert insight into PNH. Content includes articles, interviews, videos, podcasts, and breaking news on PNH research, treatment, and drug development.

Anemia

Sickle Cell

Sickle Cell condition center page, resources on the topics of medical news and expert insight into sickle cell disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on sickle cell research, treatment, and drug development.