Mohannad Abou Saleh, MD: Examining Follow-Up After Pancreatic Cyst Removal

October 29, 2020
Kenny Walter

Kenny Walter is an editor with HCPLive. Prior to joining MJH Life Sciences in 2019, he worked as a digital reporter covering nanotechnology, life sciences, material science and more with R&D Magazine. He graduated with a degree in journalism from Temple University in 2008 and began his career as a local reporter for a chain of weekly newspapers based on the Jersey shore. When not working, he enjoys going to the beach and enjoying the shore in the summer and watching North Carolina Tar Heel basketball in the winter.

Experts recommend closer follow-up after the surgical removal of pancreatic cysts.

New research presented at the annual American College of Gastroenterology (ACG) 2020 conference recommend close follow-up and continued surveillance of pancreatic cysts following surgical excision.

A team of researchers from the Cleveland Clinic described the post-surgical course of pancreatic cyst patients, while evaluating the rates and predictors of recurrent cysts, high-risk, and malignant transformation over a 5 year review of existing data.

In the cohort, the investigators examined data from 104 patients who underwent surgical intervention for pancreatic cysts with 37 (37.4%) cases undergoing pancreaticoduodenectomy and 62 (62.6%) undergoing distal pancreatectomy.

In the study there were 63% IPMN (74.55% side-branch), 14% MCN, 8% serous cystadenoma, 6% neuroendocrine neoplasm, 6% pseudocyst and 3% solid-pseudopapillary neoplasm. For surgical pathology, 27% of patients had adenocarcinoma and 14% had high grade dysplasia.

At the one-year mark following surgery, 34.5% had recent cysts with 5.1% with high-risk transformation and 11.7% malignant transformation. By year 5, these rates increased to 64.8%, 13.7%, and 19%, respectively.

The overall mortality rate was 13.5%, with 5.8% related to pancreatic causes over the 5 year review period.

In an interview with HCPLive®, Mohannad Abou Saleh, MD, an internist with the Cleveland Clinic, explained how the study relates to existing gastroenterology guidelines and what he thinks the lasting impact of the study will be.