Apremilast Shows Long-Term Benefit in Early Oligoarticular Psoriatic Arthritis

The FOREMOST trial showed large reductions in swollen joint count (SJC) and tender joint count (TJC) among patients with oligoarticular (oligo) psoriatic arthritis (PsA) taking apremilast vs placebo at week 16. Patients had sustained reductions through week 48, demonstrating the benefit of apremilast. The research was presented at the 2025 Society of Dermatology Physician Assistant (SDPA) annual summer meeting from June 25 – 29th in Washington, DC.

Oligo psoriatic arthritis, characterized by ≤ 4 active joints, can significantly impact quality of life and physical function. Investigators, led by Kristina Callis Duffin, MD, MS, a professor from the department of dermatology at the University of Utah, conducted FORMOST, a randomized, double-blind, placebo-controlled trial evaluating the effect of apremilast on weight-bearing joints in patients with early oligo PsA through week 48. Weight-bearing joints were defined as the hip, knee, ankles, midfoot, metatarsophalangeal, and proximal interphalangeal joints for the foot.

The team randomized patients 2:1 to apremilast or placebo for 24 weeks, with an option of an early escape at week 16. This was followed by an extension phase, where patients received apremilast through week 48.

It was previously reported that fewer patients receiving apremilast vs placebo progressed from ≤ 4 to > 4 active (swollen and/or tender) joints at week 16. A paper published in 2024 stated that more patients on apremilast (21.3%) than placebo (7.9%) achieved improvement on minimal disease activity joints, including sentinel joints (33.9% vs 16%) at week 16 (P = .0008).2

“FOREMOST is unique as a global randomized controlled trial exclusively studying early oligoarticular PsA,” investigators wrote in the paper. “We report the primary results of FOREMOST and show better disease control was achieved with apremilast, with greater MDA-Joints response compared with placebo at 16 weeks. These findings show apremilast treatment of early oligoarticular PsA improved clinical and patient-reported outcomes.”

During the post-hoc analysis, 187 patients with active weight-bearing joints at baseline received ≥ 1 dose of apremilast. Outcomes included the SJC, TJC, Health Assessment Questionnaire-Disability Index (HAQ-DI; range, 0 – 3; greater scores indicate worse function), 36-Item Short-Form Health Survey (SF-36 physical component score (PCS), and 12-item PsA Impact of Disease (PsAID-12) fatigue score.

A subgroup analysis examined the outcomes by baseline body mass index (BMI): < 25, 25 to < 30, and ≥ 30 kg/m2.

Compared with placebo at baseline (n = 62), the apremilast arm (n = 126) had a mean BMI of 30 kg/m2 (vs 31 kg/m2), a mean SJC of 1.5 (vs 1.2), a mean TJC of 1.9 (vs 1.8), mean active joint count of 2.1 (vs 1.9), and a mean HAQ-DI of 1.26 (vs 1.24).

Participants on apremilast had greater reductions in SJC and TJC by week 16 compared with placebo. Furthermore, patients with active-weight-bearing joints reported greater improvements in HAQ-DI for apremilast compared with placebo at week 16, with improvements sustained through week 48. Those on apremilast vs placebo also reported larger improvements in SF-36 and PsAID-12 fatigue score at week 16, regardless of BMI, and improvements sustained through week 48.

“Patients reported greater improvements in physical function with apremilast vs placebo at Week 16, with consistent results across most BMI categories,” wrote investigators.

References

1. Duffin K, Mrowietz U, Merola J, et al. Apremilast Efficacy in Patients with Early Oligoarticular Psoriatic Arthritis (PsA) Affecting Weight-bearing Joints by Body Mass Index (BMI): Results from the Randomized, Double-blind, Placebo-controlled FOREMOST Study. Presented at SDPA 2025 in Washington, DC.

2. Gossec L, Coates LC, Gladman DD, et al. Treatment of early oligoarticular psoriatic arthritis with apremilast: primary outcomes at week 16 from the FOREMOST randomised controlled trial. Ann Rheum Dis. 2024;83(11):1480-1488. Published 2024 Oct 21. doi:10.1136/ard-2024-225833