Kenny Walter is an editor with HCPLive. Prior to joining MJH Life Sciences in 2019, he worked as a digital reporter covering nanotechnology, life sciences, material science and more with R&D Magazine. He graduated with a degree in journalism from Temple University in 2008 and began his career as a local reporter for a chain of weekly newspapers based on the Jersey shore. When not working, he enjoys going to the beach and enjoying the shore in the summer and watching North Carolina Tar Heel basketball in the winter.
In a presentation at AHA, T. Jared Bunch, MD, discusses how early detection of AF could yield positive results down the line for patients.
T. Jared Bunch, MD
While there is a clear link between atrial fibrillation (AF) and dementia risk, an early diagnosis could give clinicians enough time to reduce that risk.
T. Jared Bunch, MD, cardiologist, Intermountain Medical Center, explained during the American Heart Association (AHA) 2019 Scientific Sessions in Philadelphia, that the risk of developing dementia is almost doubled for patients also suffering from AF.
“I think is critical as we examine that association between atrial fibrillation and brain injuries that we start to include cognitive scoring and subclinical stroke into all of our prospective studies,” he said. “We are missing the broad spectrum of the disease when we only focus on clinical disabling stroke.
“And I think one of the critical issues is that the entry to the brain happens very early, and we only take people that present to our clinic and have the atrial fibrillation diagnosis, looking at markers that are neuron specific.”
Bunch said the specific neurons suggest a disruption right at the brain-blood barrier in people with no history of brain injuries or cognitive dysfunction. All of the markers increase during a first-time diagnosis of atrial fibrillation in these patients.
The treatment strategy should begin very early as the biomarkers attached to the brain injury are seen very early.
“And if you look at the antibodies that are that are linked to disruption of the right blood brain barrier, they're higher in patients with atrial fibrillation and higher even further in patients that go on to develop cognitive dysfunction,” Bunch said, adding that the markers can at least suggest an entry pattern before the disease is detected clinically.”
Bunch explained that anticoagulants could be the answer in treating the disease early and preventing dementia from occurring.
One of the interesting parts of the study, according to Bunch, is that while in the general population women have a higher risk than men in developing dementia, the risk is similar for patients who are already diagnosed with AF.
Looking at patients with AF further, Bunch said the risk association was higher in the younger group of patients.
“Whenever we started [warfarin] within 30 days of clinical diagnosis dementia rates were very small,” Bunch said. “Whenever we started within 30 days of clinical diagnosis dementia rates were very small, and after 3 years we saw very little benefit. We saw a similar trend with the anti-platelet therapy, but not to the extent of warfarin over time.”
Novel therapies could be beneficial in reducing the risk of dementia in AF patients.
Bunch said dementia risk was almost 4 times lower when treated with a therapy like rivaroxaban than it was when treated with warfarin.
Other ways to reduce the symptoms of dementia in this patient group is by utilizing adaptive physiology and restoring sinus rhythm, which can impact short-term memory and cognitive function.
Bunch said between 33-50% of people in the UK will ultimately develop dementia or have a stroke.
“So, dementia is an epidemic to our health care system, and trying to understand its risk factors and prevent it maybe 20 years to 30 years before is critical,” Bunch said.
Some of the risk factors commonly associated with AF included hypertension, obesity, sleep apnea, diabetes, and metabolic syndrome.