Jason Gallagher, PharmD: Treating C Difficile Infections

August 5, 2021
Kenny Walter

Kenny Walter is an editor with HCPLive. Prior to joining MJH Life Sciences in 2019, he worked as a digital reporter covering nanotechnology, life sciences, material science and more with R&D Magazine. He graduated with a degree in journalism from Temple University in 2008 and began his career as a local reporter for a chain of weekly newspapers based on the Jersey shore. When not working, he enjoys going to the beach and enjoying the shore in the summer and watching North Carolina Tar Heel basketball in the winter.

Fecal microbiota transplantation could be crucial in the coming years in treating C difficile infections.

Fidaxomicin and vancomycin are 2 of the most commonly used and effective treatments for Clostridioides difficile infections (CDI), but cost can be a major factor in preventing more widescale use.

In an interview with ContagionLive®, Jason Gallagher, PharmD, FCCP, FIDP, FIDSA, BCPS Clinical Professor at Temple University School of Pharmacy and Clinical Pharmacy Specialist in Infectious Diseases at Temple University Hospital, said fidaxomicin was the top of the line option for patients with CDI because it results in less relapse.

“Fidaxomicin is more expensive, vancomycin costs have come down with different formulations,” Gallagher said. “But truthfully I don’t think there is any debate over what the best drug is and that is fidaxomicin.”

Gallagher, who is the Editor-in-Chief of Contagion, also said fecal microbiota transplantation could be a highly utilized procedure for C difficile patients.

This treatment is mainly effective because patients with recurrent CDI generally have less biodiversity in their colons than healthy individuals. However, the transplantation takes advantage of this fact to better increase the biodiversity in the gut.

Gallagher said there is some unknown for this therapy and investigators and stakeholders are beginning to explore just how fecal microbiota transplantation should be standardized and utilized for patients with CDI.