HCPLive 5 Stories in Under 5: Week of 05/04

Welcome to HCPLive's 5 Stories in Under 5—your quick, must-know recap of the top 5 healthcare stories from the past week, all in under 5 minutes. Stay informed, stay ahead, and let’s dive into the latest updates impacting clinicians and healthcare providers like you!

Interested in a more traditional, text rundown? Check out the HCPFive!

Top 5 Healthcare Headlines for April 28-May 4, 2025:

Obicetrapib Achieves Robust LDL-C Reductions in Phase 3 ASCVD Trials

Obicetrapib significantly reduced LDL-C as monotherapy and in combination with ezetimibe in ASCVD patients inadequately controlled by statins, according to Phase 3 data presented at EAS 2025.

MAR001 Cuts Remnant Cholesterol, Triglycerides by 50% in Phase 2a Trial

MAR001, a novel ANGPTL4-targeting monoclonal antibody, reduced remnant cholesterol and triglycerides by over 50% in high-risk patients, suggesting a promising new cardiovascular intervention strategy.

Oral Zervimesine Reduces Geographic Atrophy Lesion Growth in Phase 2 Trial

Zervimesine (CT1812) slowed lesion progression in geographic atrophy secondary to AMD in Phase 2 MAGNIFY trial results, offering a potential oral treatment option.

UBX1325 Matches Aflibercept in Vision Gains for DME at 36 Weeks

UBX1325 demonstrated noninferiority to aflibercept in visual acuity gains in patients with diabetic macular edema over 36 weeks in the Phase 2b ASPIRE study.

Roflumilast Foam 0.3% for Scalp, Body Psoriasis Effective, Safe for Patients

Roflumilast foam 0.3% achieved significant efficacy and rapid symptom control in scalp and body psoriasis, with an FDA decision expected by late May 2025.