- The autoimmune aspect of psoriatic disease, including the presence of autoreactive T cells, has been suggested, but its association with autoimmune diseases has not been consistently reported in previous studies.
- Patients with psoriatic disease had a significantly higher risk of developing various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, Crohn's disease, ulcerative colitis, alopecia areata, and type 1 diabetes.
- The risk of developing these autoimmune diseases remained significantly higher in patients with psoriatic disease after adjusting for comorbidities, insurance type, and other factors.
- Disease severity also played a role, with patients having moderate-to-severe psoriatic disease facing a higher risk of certain autoimmune diseases like type 1 diabetes, rheumatoid arthritis, and ankylosing spondylitis.
- The study indicates a potential shared autoimmune-related pathomechanism between psoriatic disease and autoimmune diseases, highlighting the need for further research and understanding in this area.