Knowledge Gap Remains for Epinephrine Use in Emergency Departments

February 26, 2022
Kenny Walter

Kenny Walter is an editor with HCPLive. Prior to joining MJH Life Sciences in 2019, he worked as a digital reporter covering nanotechnology, life sciences, material science and more with R&D Magazine. He graduated with a degree in journalism from Temple University in 2008 and began his career as a local reporter for a chain of weekly newspapers based on the Jersey shore. When not working, he enjoys going to the beach and enjoying the shore in the summer and watching North Carolina Tar Heel basketball in the winter.

In data presented at AAAAI 2022, investigators examined anaphylaxis rates in Brooklyn between 2016-2019.

While many are concerned over anaphylaxis rates increasing among the pediatric population, there remains a knowledge gap among clinicians in the use of epinephrine on pediatric patients, according to data presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting (AAAAI) 2022.

A team, led by Mansi Kothari, MD, SUNY Downstate Medical Center, identified demographic and clinical characteristics of anaphylactic patients from an emergency department in Brooklyn over a 4-year period.

The Data

In the retrospective chart review, the investigators examined data on pediatric patients treated at the University Hospital of Brooklyn emergency department for anaphylaxis allergic reactions not otherwise specified, allergic urticaria, and angioedema between 2016-2019.

The investigators assessed each patient’s chart to determine whether they met the clinical criteria for anaphylaxis.

Emergency Department Visits

Overall, they identified 97 cases that met the clinical criteria for anaphylaxis during the study period, representing 0.2% of the total emergency department visits to the hospital between 2016-2019. The mean age of patients presenting with anaphylaxis was 9.7 years, which is older than other pediatric emergency department allergy visits with a mean age of 8.1 years (P = 0.03).

In addition, the investigators found 52.5% (n = 51) cases were individuals younger than 10 years, with 23.5% (n = 12) of cases presented in individuals aged 1-2 years.

Cases were also for individuals who were most likely male (57%; n = 56 vs 43%; n = 41 female) and African American (87.6%; n = 85).

The investigators also found 28.8% (n = 28) of patients had underlying asthma, 7.2% (n = 7) had atopic dermatitis, and 53.6% (n = 52) had a history of food allergies.

However, only 28.7% (n = 27) of the patient population received epinephrine in the emergency department, while EpiPen was prescribed to 70% (n = 64) of patients at discharge.

Overall, 11% (n = 11) of the patient population was hospitalized.

For hospitalizations, 71.7% (n = 33) of food-induced individuals received an EpiPen prescription, while 73.8% (n = 31) of idiopathic, 100% (n = 1) of drug-induced, and 0% of venom-induced anaphylaxis received EpiPen prescriptions (P = 0.04).

Finally, 30% (n = 27) of patients were referred to an allergist at discharge.

“There is a knowledge gap in pediatricians’ use of epinephrine for management of anaphylaxis in both [emergency department] and outpatient care,” the authors wrote.

The study, “Clinical Characteristics of Anaphylaxis Cases in an Inner-City Pediatric Emergency Department (E.D.) in Brooklyn Over a 4 Year Period,” was published online in the Journal of Allergy and Clinical Immunology.


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