Investigators Link Farm Proximity Residence to C. Difficile

January 15, 2020
Kenny Walter

Kenny Walter is an editor with HCPLive. Prior to joining MJH Life Sciences in 2019, he worked as a digital reporter covering nanotechnology, life sciences, material science and more with R&D Magazine. He graduated with a degree in journalism from Temple University in 2008 and began his career as a local reporter for a chain of weekly newspapers based on the Jersey shore. When not working, he enjoys going to the beach and enjoying the shore in the summer and watching North Carolina Tar Heel basketball in the winter.

A new study finds women and patients with a recent history of hospitalization were more likely to be colonized with C. difficile.

L. Silvia Munoz-Price, MD, PhD

Living near a farm could increase the risk for Clostridioides difficile infections.

Investigators, led by L. Silvia Munoz-Price, MD, PhD, Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, linked the location of a patient’s residence to asymptomatic carriage of toxigenic C. difficile in a 3043-patient cohort study.

“Residential proximity to livestock farms were all significantly associated with a higher likelihood of a positive C. difficile test result,” the authors wrote. “Residential proximity to livestock farms more than doubled the probability of C. difficile colonization in patients admitted to non—hematology-oncology units.”

C. difficile represents the most frequent health care-associated infection in the US, but it can be acquired both in hospitals and community settings. About 65% of cases in the US and 74% of cases in Europe were associated with a health care setting, suggesting environmental factors could be significant causes of the infection.

According to the US Centers for Disease Control and Prevention (CDC) in 2015, there are approximately 453,000 cases of C. difficile infections annually, with an associated annual mortality of 29,300 patients.

Livestock farms particularly carry an increased likelihood of infections due to exposure to higher loads of C. difficile through water runoff and substances that disrupt the intestinal microbiome.

The retrospective cohort was conducted between May 2017 and June 2018 at Froedtert Memorial Lutheran Hospital, a 565-bed teaching-affiliated hospital in Wisconsin. All patients underwent C. difficile screening using a nucleic acid amplification test at hospital admission. Stool samples were also collected for C. difficile testing.

The investigators sought a positive result on the C. difficile screening tests performed within 72 hours of hospital admission as the main outcome of the study.

The team also performed multivariable logistic analysis on a stratified sample of patients based on hematology-oncology admission status. Through this analysis, the investigators found that patients admitted to the hematology-oncology units were 35% more likely to be colonized with C. difficile.

However, there were no significant association between the patients sociodemographic and economic characteristics or health care and environmental exposures with the likelihood of a positive C. difficile test result.

Recent history of hospitalization—hospitalization within the preceding 6 months—increased the likelihood of colonization by 70% (OR, 1.66; 95% CI, 1.06-2.61).

Women also had 60% greater colonization than men (OR, 1.60; 95% CI, 1.03-2.46).

On the other hand, patients not admitted to a hematology-oncology unit with comorbidities had an increased likelihood for colonization by more than 4 times.

Overall, a shorter distance between a residence and a livestock farm is associated with an increased rate of C. difficile colonization (OR, .68; 95% CI, .49-.90).

The investigators suggested future studies examine the link between C. difficile and livestock farms in other geographic areas and the underlying mechanisms of the association.

The study, “Association Between Environmental Factors and Toxigenic Clostridioides difficile Carriage at Hospital Admission,” was published online in Infectious Diseases.