The HCPFive: Top News for Healthcare Providers from the Week of 01/25

Welcome to The HCPFive, your go-to roundup for the latest healthcare news and breakthroughs, curated specifically for busy healthcare professionals.

Each week, we highlight 5 key developments or headlines from healthcare that you need to know—whether it's a cutting-edge treatment, regulatory updates, or innovations shaping the future of medicine. This week's top stories include new phase 2 data on CT-388 for obesity, the US Food and Drug Administration (FDA) approval of a labeling supplement permitting repeat administration of travoprost intracameral implant (iDose TR) in open-angle glaucoma or ocular hypertension, new American Society of Hematology (ASH) guidelines on light chain (AL) amyloidosis, the FDA approval of carbachol and brimonidine tartrate ophthalmic solution 2.75%/0.1% (Yuvezzi) for presbyopia, and the US Centers for Medicare & Medicaid Services selection of 15 high-cost drugs for the third cycle of the Medicare Drug Price Negotiation Program, including the first-ever Part B drugs.

With The HCPFive, you'll get the essential takeaways to stay informed and ahead of the curve. Here’s your quick dive into the top stories for the week of January 25, 2026—let’s jump in!

Genentech Reports Positive Results from Phase 2 Trial of CT-388 in Obesity

On January 27, 2026, Genentech, a member of the Roche Group, announced positive topline results from CT388-103, a phase 2 clinical trial of CT-388, an investigational dual GLP-1/GIP receptor agonist being developed for the treatment of obesity.

Results showed once-weekly subcutaneous injections of CT-388 titrated up to 24 mg resulted in significant and clinically meaningful placebo-adjusted weight loss of 22.5% (efficacy estimand) without reaching a weight loss plateau at 48 weeks. A clear dose-response relationship on the weight loss was also observed.

FDA Approves Labeling Update for iDose TR for Open-Angle Glaucoma and Ocular Hypertension

On January 28, 2026, the FDA approved a labeling supplement permitting repeat administration of travoprost intracameral implant (iDose TR) for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension. The update modifies prior labeling that limited use to a single administration and is based on accumulated clinical safety data, including corneal endothelial outcomes, submitted by the manufacturer.

ASH Releases New Clinical Practice Guidelines for Diagnosing AL Amyloidosis

On January 28, 2026, ASH published new clinical practice guidelines aimed at improving the early, timely, and accurate diagnosis of AL amyloidosis. The document, published in Blood Advances, outlines best practices to support clinicians in recognizing and diagnosing AL amyloidosis, a disease frequently missed or diagnosed late due to its heterogeneous presentation.

FDA Approves First Dual-Agent Eye Drop for Near Vision Loss

On January 28, 2026, the FDA approved Tenpoint Therapeutics’ carbachol and brimonidine tartrate ophthalmic solution 2.75%/0.1% (Yuvezzi) for the treatment of presbyopia in adults, representing the first regulatory authorization of a fixed-dose, dual-agent topical therapy for age-related near vision degradation.

CMS Selects 15 Drugs for Third Cycle of Medicare Drug Price Negotiation Program

On January 27, 2026, the US Centers for Medicare & Medicaid Services (CMS) announced the selection of 15 high-cost prescription drugs covered under Medicare Part D and, for the first time, drugs payable under Medicare Part B for the third cycle of the Medicare Drug Price Negotiation Program. CMS additionally selected 1 previously negotiated drug, linagliptin (Tradjenta), for the program’s first renegotiations. Negotiations with participating drug companies will occur in 2026 and any negotiated and renegotiated prices will become effective January 1, 2028.