Emerging Innovations in Post-Event Lipid Management for ASCVD

The panelists conclude by examining emerging innovations in post-event lipid management aimed at improving outcomes for patients with ASCVD. They highlight a shift toward earlier initiation of intensive LDL-C lowering—beginning during hospitalization or soon after discharge—to prevent recurrent events during the period of highest vulnerability. The experts discuss the growing use of siRNA-based therapies such as inclisiran and the development of next-generation PCSK9-targeting agents that combine potency with simplified dosing schedules to improve adherence. They also note increasing interest in combination approaches, including pairing statins with bempedoic acid or PCSK9-directed therapies for sustained LDL-C control. The conversation underscores the importance of integrating lipid management into hospital discharge planning and ensuring seamless transitions to outpatient care. The panelists express optimism that continued innovation—coupled with improved access and education—will help clinicians achieve earlier, more durable LDL-C reduction and ultimately reduce recurrent ASCVD events.

Videos

Experts discuss groundbreaking innovations in cardiovascular disease prevention, highlighting personalized medicine and new therapies for effective treatment.

Clinical

clinical page is a resource for content on every specialty, disease, and topic available on our medical news site.

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Sustaining Long-Term Adherence to PCSK9 Therapy in ASCVD

The panelists discuss strategies to improve long-term adherence to PCSK9-targeting therapies among patients with ASCVD. They note that while these agents are highly effective, adherence often declines after the first year due to cost, complex refill processes, and perceived lack of symptoms once LDL-C levels normalize. The experts emphasize that successful long-term use depends on simplifying care pathways, such as incorporating pharmacy-led coordination, automated refill reminders, and structured follow-up visits. They highlight the advantage of siRNA-based therapies like inclisiran, which require administration only twice per year, reducing the burden of self-injection and improving persistence. The panelists also stress the importance of patient education—helping individuals understand that LDL-C reduction is a lifelong goal, not a short-term fix. By combining streamlined delivery models, consistent communication, and shared accountability among the care team, clinicians can sustain adherence and maximize the benefits of PCSK9 therapy in ASCVD management.

Engaging patients in their treatment journey enhances adherence to therapies, ultimately improving health outcomes and managing cholesterol effectively.

Alex Hillenbrand is an assistant editor for 

. She earned her BA in English from Lafayette College in 2023 and went on to write for pop culture, entertainment, and sports media outlets before joining MJH Life Sciences in 2025. In her free time, Alex enjoys cooking, going on walks, and meeting new people. Contact her at mjhlifesciences.com.

 landscape was limited to immunosuppressive strategies and supportive care, such as blood pressure management and RAAS inhibition, leaving many patients to experience ongoing disease progression or recurrence after kidney transplantation. The scarcity of targeted therapies makes 2025 a landmark year for this rare kidney disease.

In March 2025, the US Food and Drug Administration (FDA) approved oral iptacopan (Fabhalta) for adults with C3G, demonstrating significant proteinuria reduction and kidney function stabilization in the phase 3 APPEAR-C3G trial. Later in July, the FDA approved pegcetacoplan (Empaveli) for adolescents and adults with C3G, including those with post-transplant recurrence. Phase 3 VALIANT trial data showed durable complement inhibition, proteinuria reduction, stabilization of estimated glomerular filtration rate (eGFR), and evidence of C3 deposit clearance.

These approvals signal the first disease-modifying therapies for C3G, moving management beyond nonspecific immunosuppression and supportive care and offering the potential to meaningfully alter disease trajectory in both native and post-transplant kidneys.

’s 2025 editorial coverage of the emerging treatment landscape for C3G and understand its implications for kidney care.

FDA Approves Oral Iptacopan (Fabhalta) as First C3 Glomerulopathy Therapy

Novartis announced FDA approval of oral iptacopan (Fabhalta) on March 20, 2025, for adults with C3G to reduce proteinuria. This first-ever approval for the ultra-rare disease was based on phase 3 APPEAR-C3G trial data, representing a milestone in targeted complement therapy and offering a new oral alternative for disease management.

FDA Approves Pegcetacoplan (Empaveli) for C3 Glomerulopathy, IC-MPGN

Apellis Pharmaceuticals’ pegcetacoplan (Empaveli) was approved for patients ≥12 years of age with C3G or primary immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN), including post-transplant disease recurrence. 

Announced on July 28, 2025, the approval was supported by positive 26-week results from the phase 3 VALIANT trial, the largest single study in these rare diseases. The FDA clearance provides clinicians with a targeted therapy stabilizing kidney function while addressing complement-mediated pathology across age groups and transplant settings.

Phase 3 VALIANT Results for Pegcetacoplan In C3G, IC-MPGN, With Andrew Bomback, MD

VALIANT demonstrated a 68% reduction in proteinuria and stabilization of kidney function in adult and adolescent patients with C3G and IC-MPGN. Evidence of C3 deposit clearance, including in post-transplant recurrence, highlights pegcetacoplan’s ability to directly target pathogenic complement activity. These results signal a meaningful shift toward precision, mechanism-based therapy in a condition that previously relied on nonspecific immunosuppression.

APPEAR-C3G: Iptacopan Shows Proteinuria Reduction, eGFR Benefits in C3G

Phase 3 APPEAR-C3G data showed iptacopan produced rapid and sustained proteinuria reduction, stabilized eGFR, and decreased C3 deposits over 12 months in patients with biopsy-confirmed C3G.

 Iptacopan met the primary endpoint of reducing 24-hour urine protein-to-creatinine ratio (UPCR) by 35.1% (95% Confidence Interval [CI], 13.80 to 51.10; 

 = .0014), with sustained reductions at 12 months. The oral alternative complement pathway inhibitor’s efficacy reinforces the emergence of complement-targeted therapies as a new standard for ultra-rare glomerular diseases, potentially improving long-term renal outcomes.

C3G During Pregnancy Linked to Adverse Renal, Obstetric Outcomes

A retrospective analysis from the University of Iowa’s C3G Natural History Study found higher risks of preeclampsia, prematurity, and renal decline in pregnant patients with C3G compared with healthy controls.

“These data provide a preliminary maternal-risk profile for C3G patients who are considering pregnancy and allow for certain risk scenarios to be considered and managed prospectively,” Lauren Fergus, of the Molecular Otolaryngology and Renal Research Laboratories at the University of Iowa, wrote. “Ultimately, the elevated chances of adverse events support the need for multidisciplinary pre- and peri-pregnancy care involving obstetrics, nephrology, and pediatrics as a mechanism for improving outcomes of both mother and baby.”

The findings underscore the importance of coordinated, personalized care in C3G to mitigate both maternal and fetal risks.

C3G, IC-MPGN Report A Disruptive Burden Regardless of Slowed Disease Progression

A multinational, cross-sectional survey found patients and caregivers experience substantial clinical, economic, and quality-of-life impacts, even when disease progression is slow or stable. These results emphasize that, despite emerging therapies, ongoing support and management strategies remain critical to address the broader burden of ultra-rare glomerular diseases.

Pegcetacoplan's Approval & Shifting C3G Landscape, with Sayna Norouzi, MD

For a condition previously lacking approved therapies and relying on nonspecific immunosuppressants, the arrival of two targeted options in under a year marks a dramatic shift for patients and clinicians.

“This is really, really groundbreaking news for our patients and for us as nephrologists because for years and years, patients with C3G came to our clinics and we didn't have any specific FDA-approved medications for them,” said Sayna Norouzi, MD, assistant professor of medicine, clinical nephrologist, and founder and director of the Glomerular Disease and Polycystic Kidney Disease Clinics at Loma Linda University Medical Center.

The new approvals signal a turning point in C3G care, moving toward mechanism-based interventions with potential to improve long-term kidney outcomes and patient quality of life.

VALIANT: Pegcetacoplan Shows Sustained Efficacy in C3G and IC-MPGN, With Carla Nester, MD

Expert Perspectives: Iptacopan FDA Approval for C3 Glomerulopathy

For additional insight into the significance of the approval of iptacopan and its impact on C3G care, the editorial team of 

 spoke with Gerald Appel, MD, a professor of clinical medicine, director of clinical nephrology, and director of the Glomerular Disease Center at Columbia University; Andrew Bomback, MD, an assistant professor of medicine at Columbia University Medical Center; and Jared Hassler, MD, a pathologist at the Temple University Hospital.

Articles

The landscape of C3 glomerulopathy (C3G) treatment has evolved significantly with the FDA's approval of two targeted therapies in 2025. Oral iptacopan (Fabhalta) and pegcetacoplan (Empaveli) have shown promising results in reducing proteinuria and stabilizing kidney function, marking a shift from traditional immunosuppressive strategies. These approvals represent the first disease-modifying therapies for C3G, offering new hope for patients, including those with post-transplant recurrence. Despite these advancements, the disease continues to impose a substantial burden on patients' quality of life, necessitating ongoing support and management.

C3G treatment advances in 2025 with FDA approvals of iptacopan and pegcetacoplan, offering disease-modifying options


News

news page, resources on the topics of disease- and specialty-specific medical news and expert insight can be found. Content includes articles, interviews, videos, podcasts, and breaking news on health care research, treatment, and drug development.

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

C3 Glomerulopathy

The HCPLive C3 glomerulopathy page is a resource for medical news and expert insights on C3G. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in C3G, and more.

C3 Glomerulopathy in 2025: Year in Review

 has granted 510(k) clearance to Theracor, the first human umbilical cord–derived medical device offered in a sheet formulation, according to an announcement from StimLabs on December 29, 2025.

“Receiving 510(k) clearance for Theracor underscores our leadership and offers greater options to clinicians and patients who benefit from human tissue-based solutions for the management of acute and chronic wounds,” said John Daniel, founder and chief executive officer of StimLabs, in a statement.

The clearance is an expansion upon the FDA’s prior authorization of Corplex P, the first FDA 510(k) cleared human umbilical cord-derived medical device for wound management provided in a particulate format. Unlike particulate formulations, the sheet format is designed for clinicians who require a continuous wound coverage option with a comparable human tissue-based medical device. The sheet formulation offers an alternative delivery format for these clinicians, according to the statement from StimLabs.

Theracor is derived from human umbilical cord extracellular matrix (ECM) and is intended to cover and protect wounds while maintaining a moist wound environment. The device is indicated for the same wound types as Corplex P, including partial- and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled and undermined wounds, surgical wounds including donor sites, grafts, post-Mohs surgery, and wound dehiscence, trauma wounds, partial-thickness burns, skin tears, and draining wounds.

According to the company, the clearance reflects the continued expansion of FDA-cleared umbilical cord–derived medical devices intended for use in complex wound management settings.

“By expanding our product portfolio, we empower clinicians with choice and strengthen our commitment to innovating around unmet clinical needs while meeting the highest standards," stated John Daniel. "With Corplex P already FDA cleared and available nationwide, Theracor rounds out our offering, arming wound care providers with an expanded suite of human umbilical-cord derived devices."

StimLabs. StimLabs® Announces FDA Clearance of TheracorTM: The First Human Umbilical Cord-Derived Medical Device Sheet. Prnewswire.com. Published December 29, 2025. Accessed December 29, 2025. 

https://www.prnewswire.com/news-releases/stimlabs-announces-fda-clearance-of-theracor-the-first-human-umbilical-cord-derived-medical-device-sheet-302649759.html

FDA Clears Groundbreaking Corplex-PTM: The First Human Umbilical Cord-Derived Medical Device Corplex-P. StimLabs. 

https://stimlabs.com/Corplex-P_Press_Release/

The FDA has granted 510(k) clearance to Theracor, a human umbilical cord-derived medical device in sheet form, developed by StimLabs. This clearance expands upon the previous authorization of Corplex P, a particulate format device. Theracor provides continuous wound coverage and is intended for various wound types, including ulcers, burns, and surgical wounds. The clearance signifies the growing acceptance of umbilical cord-derived devices in complex wound management. StimLabs aims to offer clinicians more options and address unmet clinical needs with their expanded product portfolio.

FDA clears first human umbilical cord–derived sheet device, Theracor, for wound Care


FDA News

FDA Grants 510(k) Clearance to First Umbilical Cord–Derived Sheet Formulation for Wound Care

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

Skin of Color Savvy: The Art and Science of Treating Patients of Color

The Skin of Color Savvy podcast, presented by Skin of Color Society (SOCS) leaders and produced by HCPLive, presents a special year-end highlights reel to close out 2025, featuring moments from every 'Savvy Conversations' episode released throughout 2025. The compilation reflects the breadth of topics, voices, and lived experiences that shaped the podcast’s inaugural year, underscoring its commitment to advancing clinically rigorous, culturally responsive dermatologic care for patients of color.  Throughout the season, expert dermatologists explored conditions that disproportionately affect patients with skin of color, including atopic dermatitis, prurigo nodularis, vitiligo, pigmentary disorders, hidradenitis suppurativa, scarring alopecia, and curly hair–specific concerns. In conversations featuring Andrew Alexis, MD, MPH, and Shawn Kwatra, MD, the discussion centered on the biologic and social drivers of itch and inflammatory skin disease, highlighting how environmental exposures and health disparities intersect with cutaneous health.  Pigmentary disorders were a recurring theme, with episodes featuring Nada Elbuluk, MD, MSc, Michelle Rodrigues, MBBS, Esther Freeman, MD, PhD, and Karolyn Wanat, MD, emphasizing the diagnostic complexity of hyperpigmentation, hypopigmentation, and depigmentation across diverse skin types. These conversations reinforced the importance of nuanced clinical evaluation and patient-centered decision-making, particularly when conditions such as vitiligo are incorrectly dismissed as cosmetic.  Hair and scalp disorders were another focal point of the season. Episodes with Crystal Aguh, MD, John Harris, MD, PhD, Loren Krueger, MD, Victoria Barbosa, MD, MPH, MBA, Janiene Luke, MD, Amy McMichael, MD, and Kayla Taylor, MD, addressed scarring and non-scarring alopecias, the role of hair-care practices, and the cultural significance of curly and textured hair. Panelists stressed that hair loss often requires time-intensive visits, longitudinal care, and open conversations about styling, identity, and patient expectations.  Patient perspective was powerfully incorporated during the episode featuring Tiffany Mayo, MD, Steven Daveluy, MD, and patient advocate Jasmine Ivanna Espy, who shared her lived experience with hidradenitis suppurativa. Her story highlighted the diagnostic delays, emotional burden, and quality-of-life impact of chronic inflammatory disease, reinforcing the importance of listening to patients as partners in care.  Additional episodes tackled sunscreen counseling, winter skin care, and the need for diversity in clinical trials, with insights from Rebecca Vasquez, MD, Adewole Adamson, MD, MPP, Raj Chovatiya, MD, PhD, and Tasneem Mohammad, MD, alongside discussions on global dermatologic equity and the expanding role of organizations like the Skin of Color Society.  Together, the year-end reel captures the essence of Skin of Color Savvy: a platform grounded in evidence-based medicine, cultural humility, and inclusive dialogue. As the podcast looks ahead to the coming year, the highlights serve as a reminder of the progress made, and the work still needed, to improve dermatologic care for all patients.  To learn more about SOCS’s mentorship programs and initiatives, visit Skin of Color Society.  Editor’s note: This summary was edited with the help of artificial intelligence tools.

, presents a special year-end highlights reel to close out 2025, featuring moments from every 'Savvy Conversations' episode released throughout 2025. The compilation reflects the breadth of topics, voices, and lived experiences that shaped the podcast’s inaugural year, underscoring its commitment to advancing clinically rigorous, culturally responsive dermatologic care for patients of color.

Throughout the season, expert dermatologists explored conditions that disproportionately affect patients with skin of color, including atopic dermatitis, prurigo nodularis, vitiligo, pigmentary disorders, hidradenitis suppurativa, scarring alopecia, and curly hair–specific concerns. In conversations featuring Andrew Alexis, MD, MPH, and Shawn Kwatra, MD, the discussion centered on the biologic and social drivers of itch and inflammatory skin disease, highlighting how environmental exposures and health disparities intersect with cutaneous health.

Pigmentary disorders were a recurring theme, with episodes featuring Nada Elbuluk, MD, MSc, Michelle Rodrigues, MBBS, Esther Freeman, MD, PhD, and Karolyn Wanat, MD, emphasizing the diagnostic complexity of hyperpigmentation, hypopigmentation, and depigmentation across diverse skin types. These conversations reinforced the importance of nuanced clinical evaluation and patient-centered decision-making, particularly when conditions such as vitiligo are incorrectly dismissed as cosmetic.

Hair and scalp disorders were another focal point of the season. Episodes with Crystal Aguh, MD, John Harris, MD, PhD, Loren Krueger, MD, Victoria Barbosa, MD, MPH, MBA, Janiene Luke, MD, Amy McMichael, MD, and Kayla Taylor, MD, addressed scarring and non-scarring alopecias, the role of hair-care practices, and the cultural significance of curly and textured hair. Panelists stressed that hair loss often requires time-intensive visits, longitudinal care, and open conversations about styling, identity, and patient expectations.

Patient perspective was powerfully incorporated during the episode featuring Tiffany Mayo, MD, Steven Daveluy, MD, and patient advocate Jasmine Ivanna Espy, who shared her lived experience with hidradenitis suppurativa. Her story highlighted the diagnostic delays, emotional burden, and quality-of-life impact of chronic inflammatory disease, reinforcing the importance of listening to patients as partners in care.

Additional episodes tackled sunscreen counseling, winter skin care, and the need for diversity in clinical trials, with insights from Rebecca Vasquez, MD, Adewole Adamson, MD, MPP, Raj Chovatiya, MD, PhD, and Tasneem Mohammad, MD, alongside discussions on global dermatologic equity and the expanding role of organizations like the Skin of Color Society.

Together, the year-end reel captures the essence of 

: a platform grounded in evidence-based medicine, cultural humility, and inclusive dialogue. As the podcast looks ahead to the coming year, the highlights serve as a reminder of the progress made, and the work still needed, to improve dermatologic care for all patients.

To learn more about SOCS’s mentorship programs and initiatives, visit 

Editor’s note: This summary was edited with the help of artificial intelligence tools.

In this end-of-year reel, HCPLive has showcased several key highlights from the Skin of Color Savvy podcast in 2025.

Hosted by Skin of Color Society and produced by HCPLive, 

 delves into the latest research, clinical insights, and culturally intelligent care practices in dermatology with leading experts. 

Whether it’s groundbreaking research, practice-changing insights, or highlights from the SOCS community, this twice-monthly program provides dermatologists and care providers with expert perspectives on treating patients with skin of color.

Podcasts

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The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

Skin of Color Savvy: Highlights from 2025

The FDA grants breakthrough therapy designation for ulizacaltamine for the treatment of essential tremor. 


Parkinson Disease

The HCPLive Parkinson's disease page is a comprehensive resource for clinical news and insights on PD. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for movement disorders, and more.

FDA Grants Breakthrough Therapy Designation for Ulizacaltamine in Essential Tremor 

Chelsie Derman is an associate editor for 

who covers psychiatry, sleep medicine, geriatrics, migraine, and allergy. She joined MJH Life Sciences in September 2023 after graduating from The College of New Jersey with a bachelor’s degree in journalism and professional writing. In her free time, she enjoys creative writing and reading.

In 2025, psychiatry saw major FDA approvals, novel treatments, and pivotal clinical updates that are transforming care for depression, ADHD, schizophrenia, and anxiety.

Psychiatry

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Major Depressive Disorder

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​​Psychiatry in 2025: Year in Review

Abigail Brooks is an assistant managing editor for 

She joined MJH Life Sciences in August 2023 shortly after graduating from Monmouth University where she earned her BA in Communication with a concentration in Public Relations/Journalism and later an MA in Interactive Digital Media. She enjoys traveling, running, and reading books. She can be reached at abrooks@mjhlifesciences.com.

The gastroenterology year in review covers FDA approvals, IBD breakthroughs, IL-23 therapies, new guidelines, and advances in GI care.

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, IBS and IBD, Crohn's disease, and more.

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Gastroenterology in 2025: Year in Review

Ryan Livingston joined the MJH Life Sciences team in March of 2025, shortly after graduating from TCNJ with a bachelor’s degree in English. He enjoys creative writing, reading, and scuba diving. He can be reached at rlivingston@mjhlifesciences.com.

Catch up on the most impactful headlines in HF from all of 2025 with our Year in Review.

Cardiology

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Heart Failure in 2025: Year in Review

Victoria Johnson joined the MJH Life Sciences in 2020 and has written for NeurologyLive, CGTLive, and now HCPLive. You can reach her at vjohnson@mjhlifesciences.com

The asthma year in review highlights FDA approvals, data, and advances in 2025.

Psoriatic Arthritis

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Psoriatic Arthritis in 2025: Year in Review

IgA nephropathy advanced in 2025 with FDA approvals, positive phase 3 trials, and growing disease-modifying therapies


IgA Nephropathy

The HCPLive Berger disease page is a resource for medical news and expert insights on IgA nephropathy. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in Berger disease, and more.

IgA Nephropathy in 2025: Year in Review

New CDC recommendations on hepatitis B vaccination raise concerns over increased infections and healthcare costs, complicating public health efforts.

Infectious Disease

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This Year In Medicine

New Hepatitis B Vaccine Recommendation Serves as a Blueprint for Federal Vaccine Policy Going Forward 

Catch up on news headlines highlighted in the dermatology space by HCPLive in 2025 with this Year in Review.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

Atopic Dermatitis

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Dermatology in 2025: Year in Review

Allergy

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Food Allergy

Seasonal Allergy

Anaphylaxis

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​​Allergy in 2025: Year in Review

The hepatology year in review highlights FDA approvals, MASH therapies, viral hepatitis advances, cholestatic disease shifts, and evolving clinical guidance.

Hepatology

MASH / MASLD

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Latest News

Emerging Innovations in Post-Event Lipid Management for ASCVD

Sustaining Long-Term Adherence to PCSK9 Therapy in ASCVD

C3 Glomerulopathy in 2025: Year in Review

FDA Grants 510(k) Clearance to First Umbilical Cord–Derived Sheet Formulation for Wound Care

Skin of Color Savvy: Highlights from 2025