Lance L. Stein, MD

In this episode, “Key Symptoms of PBC: Fatigue, Pruritus, and Bone Health,” the expert hepatologists explore extrahepatic symptoms associated with this disease. 

Segment 2- Key Symptoms of PBC- Fatigue, Pruritus, and Bone Health

In this episode, “Key Symptoms of PBC: Fatigue, Pruritus, and Bone Health,” the expert hepatologists explore extrahepatic symptoms associated with this disease.

Led by the moderator, the panelists examine the following critical questions:

What do we know about the underlying causes of these extrahepatic symptoms of primary biliary cholangitis?

Another common complication associated with PBC is bone disease; about 30% of patients with PBC also have osteoporosis. How often do you see bone complications in clinic, and how does it impact a patient’s quality of life?

Throughout the conversation, the experts provide a comprehensive reflection on the field and the factors that may shape how clinicians approach care moving forward.

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Explore the complex relationship between pruritus, fatigue, and bone health in patients with primary biliary cholangitis (PBC).

In this episode titled, “An Overview of PBC Pathophysiology, Severity, and Burden,” Aparna Goel, Lance L. Stein, A. Sidney Barritt IV, and Frances Lee highlight the key symptoms and burdens associated with primary biliary cholangitis (PBC)

Segment 1- An Overview of PBC Pathophysiology, Severity, and Burden

Led by the moderator, the expert hepatologists examine the following critical questions:

Please provide an overview of primary biliary cholangitisand signs and symptoms of PBC (hepatic/extrahepatic).


What are the known risk factors for primary biliary cholangitis (such as female sex and age)? What do we know about the underlying reasons for these risks?

What is our understanding of underlying causes leading to a manifestation of primary biliary cholangitis?

How do you assess the severity of primary biliary cholangitis in a patient and their risk of progression?

Please discuss the burden of primary biliary cholangitis and how symptoms like fatigue and pruritus are distinct and can dramatically impact patient quality of life.

Explore expert insights on primary biliary cholangitis, focusing on symptoms, treatment innovations, and emerging clinical data for effective patient management.

Lance L. Stein, MD

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