- Gradually reducing antipsychotic dosage in individuals with psychotic disorders, including schizophrenia, increases the risk of severe relapse. This finding suggests caution when considering dose reduction or discontinuation.
- Lowering antipsychotic medication dosage does not result in improved social functioning for patients with psychotic disorders, as assessed by the Social Functioning Scale. Therefore, clinicians should not expect social functioning benefits from dose reduction.
- Despite lower medication doses in the reduction group, adverse effects such as bodyweight changes and sexual dysfunction did not decrease significantly. Clinicians should be aware that dose reduction may not alleviate these side effects.
- The study revealed that there were more serious adverse effects and natural deaths in the reduction group compared to the maintenance group, emphasizing the potential safety risks associated with antipsychotic dose reduction.
- Patients in the reduction group had a higher risk of severe relapse compared to those on maintenance treatment. This finding underscores the importance of ongoing maintenance treatment in preventing relapse.