Exploring Research Needs and Resources in HS Care

Critical research gaps in hidradenitis suppurativa (HS) include the need for pediatric studies, as current approval for adalimumab in patients aged 14 years and above relied on pharmacokinetic modeling rather than dedicated pediatric trials. Understanding disease progression and identifying predictive biomarkers could enable earlier intervention in patients at high risk for severe disease development, potentially altering the natural history through timely therapeutic intervention. Management of acute flares represents another pressing need, as current biologics reduce flare frequency but don’t eliminate them, leaving patients and providers without evidence-based rescue strategies.

Emerging research questions include whether early disease control can prevent the metabolic and inflammatory comorbidities commonly associated with HS or whether some comorbidities actually contribute to disease initiation and could be targeted for prevention. The relationship between HS and conditions like arthritis, inflammatory bowel disease, and metabolic syndrome requires deeper investigation to optimize holistic patient care. Additionally, addressing the cosmetic impact of residual scarring and hyperpigmentation after achieving inflammatory control represents an important quality of life consideration, with preliminary work exploring ablative lasers, fractional treatments, and microneedling approaches adapted from acne scar management.

Educational resources for clinicians continue expanding through multiple channels including the annual HiSTORIC conference, resident symposia that have evolved from niche events to high-demand educational opportunities, and online learning platforms. The HS Foundation website provides practical tools including prior authorization resources, wound care guidance, and educational modules for emergency department physicians and other nondermatology providers. Academic supplements, surgical video libraries, journal clubs, and basic science seminars through professional organizations offer ongoing learning opportunities at various career stages, supporting the growing community of practitioners committed to advancing HS care and improving patient outcomes.