Rethinking Treatment Goals in Psoriasis: Leveraging IL-17 Inhibitors to Move Beyond Skin Clearance Toward PsA Prevention - Episode 13
Redefining Treatment Success and Remission in Psoriasis Care
In this episode, the panelists discuss how the definition of treatment success and remission in psoriasis has evolved. Historically, achieving PASI 75 was considered adequate, but the experts explain that PASI 100, or complete skin clearance, is now the preferred benchmark. They reference the National Psoriasis Foundation’s 2025 consensus statement, which defines remission as maintaining ≤1% body surface area involvement for at least six months and a DLQI score of 0 or 1, indicating no impact on quality of life. The panelists emphasize that complete skin clearance reflects a deeper suppression of systemic inflammation and may reduce the risk of psoriatic arthritis. They also highlight that visible clearance serves as a practical measure in the absence of validated biomarkers. With current systemic therapies making PASI 100 an attainable goal, the experts agree that striving for sustained remission represents both clinical success and improved long-term outcomes.
In this episode, the panelists discuss how the definition of treatment success and remission in psoriasis has evolved. Historically, achieving PASI 75 was considered adequate, but the experts explain that PASI 100, or complete skin clearance, is now the preferred benchmark. They reference the National Psoriasis Foundation’s 2025 consensus statement, which defines remission as maintaining ≤1% body surface area involvement for at least six months and a DLQI score of 0 or 1, indicating no impact on quality of life. The panelists emphasize that complete skin clearance reflects a deeper suppression of systemic inflammation and may reduce the risk of psoriatic arthritis. They also highlight that visible clearance serves as a practical measure in the absence of validated biomarkers. With current systemic therapies making PASI 100 an attainable goal, the experts agree that striving for sustained remission represents both clinical success and improved long-term outcomes.
