In this episode, the panel discusses how Sjögren’s Disease (SjD) progresses over time and what factors may signal higher risk for severe outcomes, including lymphoma development. While many patients experience primarily glandular symptoms, others develop systemic involvement, driven by chronic immune activation. The panel highlights clinical and laboratory features associated with more aggressive disease, such as persistent parotid or salivary gland swelling, low complement levels, cryoglobulinemia, high IgG, and vasculitis. These markers reflect heightened B-cell activation, which is central to SjD pathogenesis and contributes to the increased risk of B-cell lymphoma seen in a subset of patients.

The conversation emphasizes the importance of longitudinal monitoring, as disease progression is often gradual and may evolve over years. Clinicians must look for early warning signs, particularly changes in glandular swelling, new systemic symptoms, or abnormal labs. Identifying patients at higher risk enables closer follow-up, timely intervention, and discussions regarding therapy aimed at modifying disease activity.