Aleena Banerji, MD, professor at Harvard Medical School and director of clinical care at the Center for Drug and Vaccine Allergy at Massachusetts General Hospital.

Single-Dose Lonvo-z Cuts HAE Attacks by 87% in Phase 3 Trial, With Aleena Banerji, MD

A single dose of lonvoguran ziclumeran (lonvo-z) reduced 

 attack rates by 87% compared with placebo in the phase 3 HAELO trial, Intellia Therapeutics shared on April 27, 2026.

, lead investigator Aleena Banerji, MD, professor at Harvard Medical School and director of clinical care at the Center for Drug and Vaccine Allergy at Massachusetts General Hospital, highlighted the efficacy and safety of lonvoguran ziclumeran for HAE observed over 6 months. Lonvoguran ziclumeran, an in vivo CRISPR-based gene editing therapy, uses CRISPR/Cas9 technology to target and inactivate the KLKB1 gene in hepatocytes, reducing kallikrein production and downstream bradykinin generation.

Patients receiving lonvoguran ziclumeran achieved a mean monthly attack rate of 0.26 compared with 2.10 in the placebo arm (

 <.0001). Furthermore, a substantial proportion of patients became both attack-free and free from long-term prophylaxis (62% vs 11% on placebo; 

“The biggest benefit that we're seeing here is a one-time treatment that is leading to a significant reduction in attacks similar to the other long-term prophylactic treatments, except that this one does not require any ongoing long-term treatment,” Banerji said.

Safety findings to date have been consistent with earlier studies, with no serious adverse events reported during the primary observation period. Common adverse events, all mild to moderate, included infusion-related reactions, headache, and fatigue. Banerji addressed the need for continued follow-up to monitor for delayed risks associated with in vivo CRISPR gene editing.

The trial design required discontinuation of baseline prophylaxis before treatment, which Banerji described as a “higher bar to meet” to demonstrate efficacy. Despite this, lonvoguran ziclumeran achieved significant reductions in attack rates, supporting its potential effectiveness in real-world settings.

Banerji noted that all patients with HAE are candidates for prophylaxis, and shared decision-making will guide adoption if approved. She added that ongoing follow-up, including multi-year safety and efficacy data, will be critical in defining the therapy’s role.

“[Lonvoguran ziclumeran is a] really exciting advance for our patients with hereditary angioedema,” she said. “We have 11 available treatments in the United States, 6 of them for long-term prophylaxis, and so this certainly adds another novel treatment option for prevention of attacks. It moves the needle quite a bit for our patients with hereditary angioedema as a one-time treatment with a significantly high rate of efficacy and very good safety data.”

Intellia Therapeutics has begun a rolling biologics license application (BLA) submission, which is expected to be completed in the second half of 2026, with a potential US launch in 2027 if approval is granted.

Derman C. Single-Dose Lonvoguran Ziclumeran Cuts HAE Attacks by 87% in Phase 3 Trial. HCPLive. Published April 27, 2026. Accessed April 27, 2026. 

https://www.hcplive.com/view/single-dose-lonvoguran-ziclumeran-cuts-hae-attacks-87-phase-3-trial

Intellia Therapeutics. Intellia Therapeutics reports positive phase 3 results in hereditary angioedema, marking a global first for in vivo gene editing. April 27, 2026. 

https://ir.intelliatx.com/news-releases/news-release-details/intellia-therapeutics-reports-positive-phase-3-results

Intellia Therapeutics Initiates Rolling Submission of Biologics License Application to FDA for Lonvoguran Ziclumeran (lonvo-z) as a One-Time Treatment for Hereditary Angioedema - Intellia Therapeutics. Intellia Therapeutics. Published on April 27, 2026. Accessed April 27, 2026. 

https://ir.intelliatx.com/news-releases/news-release-details/intellia-therapeutics-initiates-rolling-submission-biologics

Videos

Phase 3 HAELO data show an 87% reduction in hereditary angioedema attack rates with a one-time CRISPR therapy. Banerji discusses efficacy, safety, and durability.

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Welcome to The HCPFive, your go-to roundup for the latest healthcare news and breakthroughs, curated specifically for busy healthcare professionals.

Each week, we highlight 5 key developments or headlines from healthcare that you need to know — whether it's a cutting-edge treatment, regulatory updates, or innovations shaping the future of medicine. This week's top stories include a prespecified interim analysis of the phase 3 I-CAN trial showing ravulizumab reduced proteinuria in IgA nephropathy as early as week 10, 52-week REZOLVE-AA extension data demonstrating deepening hair regrowth responses with rezpegaldesleukin in severe alopecia areata, a third consecutive positive phase 3 readout for tozorakimab in COPD from the MIRANDA trial, topline results from the phase 3 HIBISCUS trial showing etavopivat met both co-primary endpoints in sickle cell disease, and FDA accelerated approval of lunsotogene parvec-cwha (Otarmeni) as the first gene therapy for OTOF-related genetic hearing loss.

With The HCPFive, you'll get the essential takeaways to stay informed and ahead of the curve. Here's your quick dive into the top stories for the week of April 19, 2026 — let's jump in!

Ravulizumab Reduces Proteinuria as Early as Week 10 in Phase 3 I-CAN Trial for IgAN

A prespecified interim analysis of the phase 3 I-CAN trial found that ravulizumab (Ultomiris), a long-acting C5 complement inhibitor administered intravenously every 8 weeks, met its primary endpoint of statistically significant and clinically meaningful proteinuria reduction based on 24-hour urine protein creatinine ratio at week 34, with rapid effects observed as early as week 10, in adults with IgA nephropathy at risk of progression. Alexion/AstraZeneca plans to seek accelerated approval in key markets while the trial continues to its week 106 eGFR endpoint, with full data to be presented at a forthcoming medical meeting.

REZOLVE-AA: 52-Week Data Highlight Positive Alopecia Areata Outcomes With Rezpegaldesleukin

New data from the blinded 16-week extension of the phase 2b REZOLVE-AA study, announced April 20, showed that 29% to 31% of patients in the low- and high-dose rezpegaldesleukin arms who had not yet reached a SALT ≤20 response by week 36 achieved new responses during the extension, with SALT ≤20 rates across the full study population reaching 25.8% and 27.6% in the low- and high-dose groups, respectively, versus 6.7% with placebo at 52 weeks. Rezpegaldesleukin, a first-in-class IL-2 pathway agonist designed to selectively expand regulatory T cells, was well tolerated through 52 weeks, with 94% of extension patients completing treatment and no discontinuations due to adverse events, supporting Nektar's plans to advance the drug into phase 3 development in severe alopecia areata.

Phase 3 MIRANDA: Tozorakimab Reduces COPD Exacerbations

AstraZeneca announced April 20 that tozorakimab met its primary endpoint in the phase 3 MIRANDA trial, demonstrating statistically significant and clinically meaningful reductions in moderate-to-severe COPD exacerbations compared with placebo in former smokers and in the overall population — including current smokers across all eosinophil levels and lung function severity stages — with patients receiving 300 mg every 2 weeks rather than the 4-week interval used in OBERON and TITANIA. The result marks the third consecutive positive phase 3 readout in the LUNA program, further establishing tozorakimab as a potential first-in-class IL-33–targeting biologic for COPD independent of eosinophil-driven disease subtypes; full numeric data remain pending presentation at a medical meeting.

Phase 3 HIBISCUS: Etavopivat Cuts VOC Events, Improves Hemoglobin in SCD

Topline results from the phase 3 HIBISCUS trial, announced April 20, showed that once-daily oral etavopivat 400 mg — an investigational pyruvate kinase-R activator — reduced vaso-occlusive crisis events by 27% and delayed time to first crisis to 38.4 weeks versus 20.9 weeks on placebo, while 48.7% of treated patients achieved a hemoglobin increase of more than 1 g/dL at week 24 compared with 7.2% on placebo. Etavopivat, which holds Fast Track, Rare Pediatric Disease, and Orphan Drug designations in the US, met both co-primary endpoints in 385 patients aged 12 years and older with sickle cell disease on background standard of care, and Novo Nordisk plans to file for initial regulatory approval in the second half of 2026.

FDA Approves Lunsotogene Parvec for OTOF-Related Genetic Hearing Loss

The FDA granted accelerated approval on April 23 to lunsotogene parvec-cwha (Otarmeni; Regeneron), the first gene therapy for OTOF-related hearing loss and the first approved gene therapy to restore a neurosensory function, based on phase 1/2 CHORD trial data in which 80% of 20 evaluable pediatric patients achieved a primary hearing threshold endpoint at 24 weeks, with 42% reaching normal hearing thresholds at 48 weeks. The single-dose AAV vector therapy is delivered via intracochlear infusion under general anesthesia and indicated for patients with molecularly confirmed biallelic OTOF variants, preserved outer hair cell function, and no prior cochlear implant in the treated ear; Regeneron announced the drug will be provided at no cost to eligible US patients, though procedure-related costs may still apply.

Articles

Five late-stage updates span complement inhibition, immune modulation, cytokine blockade, erythrocyte metabolism, and inner-ear gene replacement. Ravulizumab achieved rapid, clinically meaningful proteinuria reduction in IgA nephropathy, enabling accelerated-approval plans ahead of eGFR readout. Rezpegaldesleukin produced deepening SALT ≤20 responses through 52 weeks with favorable tolerability, supporting phase 3. Tozorakimab reduced COPD exacerbations across smoking status and eosinophil strata. Etavopivat lowered VOC burden and improved hemoglobin in sickle cell disease. FDA accelerated approval granted to lunsotogene parvec for OTOF-related pediatric deafness.

Stay updated with the latest healthcare breakthroughs, including FDA actions and new topline clinical trial data, in this week’s essential news roundup.

Hematology

Sickle Cell

Sickle Cell condition center page, resources on the topics of medical news and expert insight into sickle cell disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on sickle cell research, treatment, and drug development.

COPD

COPD condition center page, resources on the topics of medical news and expert insight into chronic obstructive pulmonary disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on COPD research, treatment, and drug development.

Alopecia

Dermatology

The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

IgA Nephropathy

The HCPLive Berger disease page is a resource for medical news and expert insights on IgA nephropathy. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in Berger disease, and more.

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

The HCPFive: Top News for Healthcare Providers from the Week of 04/19

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

Credit: Yale University School of Medicine

Oruka Therapeutics has announced encouraging interim findings from the EVERLAST-A phase 2a trial assessing ORKA-001 in individuals with 

, with clearance rates favorably comparable to currently available agents.

This study evaluating ORKA-001, an investigational half-life extended IL-23p19 monoclonal antibody, looket at patients with plaque psoriasis, a chronic, common, inflammatory skin condition often characterized by significant itch and lesions described as sharply scaly, demarcated, and erythematous plaques.

Patients with the disease were assessed in EVERLAST-A, a randomized, double-blind, placebo-controlled study.

“These data with ORKA-001 are highly compelling,” Bruce Strober, MD, PhD, clinical professor of dermatology at Yale University School of Medicine and lead investigator for EVERLAST-A, said in a statement.

 “If this type of efficacy and safety profile could be available with dosing once to twice per year, it would represent a major step forward for the field. I could envision this being the preferred product for any patient with moderate-to-severe psoriasis.”

The study was conducted within both the US and Canada across 26 sites. There were 84 total patients enrolled and randomized 3:1 to be treated with 600 mg of ORKA-001 at the 0 and 4-week marks, or with a matching placebo. Baseline characteristics were noted by Strober and coauthors as broadly consistent with those seen in recent moderate-to-severe psoriasis research.

At Week 16, they found 63.5% of ORKA-001-treated individuals attained the study’s primary endpoint of 100% in their Psoriasis Area and Severity Index (PASI) score, representing complete skin clearance.

 Additionally, the team identified identical data for Investigator's Global Assessment (IGA) scores of 0 0. Among key secondary endpoints, the investigators noted attainment among 83% of participants of PASI 90 IGA 0/1 among 84% at Week 16.

Among those in the placebo arm, 1 of 21 subjects met those thresholds, in line with historical placebo response rates.

 All of the study’s figures were calculated using non-responder imputation. Oruka noted these clearance rates were numerically superior to those reported for other interleukin (IL)-23p19 inhibitors in cross-trial comparisons. They also described such findings as comparable to the highest rates on record across any mechanism of action in the plaque psoriasis space.

ORKA-001’s safety profile was also found to be favorable, with no serious treatment-emergent adverse events (TEAEs) observed by Strober et al.

 They also found the single severe TEAE recorded in the study was seen in the placebo arm. Overall TEAE rates were similar between cohorts, with 51% in the ORKA-001 cohort versus 57% on placebo. The investigators noted upper respiratory tract infection the only event seen in 5% or more of those assessed in either group. No injection site reactions were found.

The phase 1 trial’s updated pharmacokinetic and pharmacodynamic data continue to support the potential for an annual dosing regimen, with ORKA-001 concentrations remaining above effective trough levels for a full year following a single 600 mg dose and sustained IL-23 pathway inhibition identified by the investigative team throughout.

In the company’s release, they noted plans to present longer-term EVERLAST-A data, including 28-week efficacy results for the full cohort and 52-week follow-up for a patient subset, in the second half of 2026. The phase 2b EVERLAST-B findings are anticipated for release in 2027.

Oruka Therapeutics Announces Positive Week 16 Data for ORKA-001 from the Ongoing EVERLAST-A Phase 2a Trial in Moderate-to-Severe Plaque Psoriasis. Oruka Therapeutics, Inc. April 27, 2026. 

https://ir.orukatx.com/news-releases/news-release-details/oruka-therapeutics-announces-positive-week-16-data-orka-001

Kimmel GW, Lebwohl M. Psoriasis: Overview and Diagnosis. Evidence-Based Psoriasis. 2018 Jul 1:1–16. 

Interim Week 16 results from EVERLAST-A suggest ORKA-001, a half-life–extended IL-23p19 monoclonal antibody, delivers high levels of skin clearance in moderate-to-severe plaque psoriasis with a favorable tolerability profile. In 84 randomized patients, two 600 mg doses at Weeks 0 and 4 produced PASI 100 in 63.5% and strong PASI 90/IGA responses versus minimal placebo activity using non-responder imputation. Pharmacokinetic/pharmacodynamic readouts support potential once-annual dosing, with longer-term data expected in 2026–2027.

These Week 16, phase 2a findings from the EVERLAST-A study assessing ORKA-001 highlight the treatment's potential in those with plaque psoriasis.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

EVERLAST-A: Positive Phase 2a Data Observed for ORKA-001 in Psoriasis at Week 16

Diana Isaacs, PharmD, is an endocrine clinical pharmacist, director of Education and Training in Diabetes Technology, and codirector of Endocrine Disorders in Pregnancy at the Cleveland Clinic.

Diabetes Dialogue: Technology, Therapeutics, & Real-World Perspectives!

Diabetes Dialogue: Expanding GLP-1 Usage Into Type 1 Diabetes With Viral Shah, MD

In this episode of Diabetes Dialogue, recorded on-site at the American Association of Clinical Endocrinology (AACE) Annual Meeting 2026 in Las Vegas, Nevada, cohosts Diana Isaacs, PharmD, and Natalie Bellini, DNP, welcome Viral Shah, MD, professor of endocrinology at Indiana University, for a discussion centered on the evolving role of GLP-1 receptor agonists and broader diabetes classification in type 1 diabetes care. Shah challenges the traditional distinction between type 1 and type 2 diabetes, emphasizing that type 2 diabetes lacks a definitive diagnostic test and is instead a diagnosis of exclusion based on phenotypic characteristics. He explains that patients with type 1 diabetes can also exhibit features of type 2 diabetes, making these categories non–mutually exclusive and supporting the rationale for dual diagnoses when clinically appropriate.

The group explores how this framework informs the use of GLP-1 receptor agonists in type 1 diabetes, particularly for patients with obesity, cardiovascular disease, heart failure, or chronic kidney disease. Shah notes that while obesity provides a clear indication for GLP-1 therapy, he is also comfortable using these agents in patients with lower BMI when cardiovascular or renal protection is the primary goal, with careful attention to dose adjustment and avoidance of excessive weight loss or muscle mass reduction. He adds that SGLT2 inhibitors may be preferable in some leaner patients, particularly when renal indications predominate, and highlights recent clarification that SGLT2 inhibitor use for CKD in type 1 diabetes is not considered off-label when prescribed for kidney protection rather than glycemic control.

The conversation then shifts to Shah’s broader view that type 1 and type 2 diabetes differ more in pathophysiology than in long-term disease course. He argues that both conditions share progressive beta cell dysfunction and overlapping complication risks, suggesting the field should move away from rigid separation and toward a more unified understanding of diabetes progression.

This perspective leads into a discussion of “prediabetes,” a term Shah critiques as outdated and insufficient. He reviews its historical origins as a label for intermediate hyperglycemia and argues that it has unintentionally minimized urgency by framing the condition as merely a risk factor rather than part of the disease continuum. Citing evidence of significantly elevated cardiovascular, kidney, and mortality risk in people with prediabetes, he advocates for staging type 2 diabetes similarly to type 1 diabetes, rather than maintaining an artificial threshold between “no disease” and diabetes. He notes that while therapies such as metformin, semaglutide, and tirzepatide have demonstrated benefit in delaying progression, regulatory limitations persist because prediabetes is not formally recognized as a disease state.

The episode concludes with a discussion of autoantibody screening in adults labeled with prediabetes. Shah supports broader antibody testing, particularly in younger adults, to identify individuals with early-stage type 1 diabetes who may otherwise be misclassified and present later with DKA. He emphasizes that accessible antibody testing and therapies such as teplizumab make earlier identification increasingly meaningful, while also acknowledging the importance of patient preference and individualized decision-making. Across the discussion, Shah calls for greater flexibility in diabetes classification, earlier intervention across the disease spectrum, and a more proactive approach to preventing complications rather than waiting for traditional diagnostic thresholds to be crossed.

Editors’ Note: Isaacs reports disclosures with Dexcom, Abbott, Lilly, Novo Nordisk, Medtronic, Insulet, and others. Bellini reports disclosures with Abbott Diabetes Care, MannKind, Povention Bio, and others. Shah reports disclosures with Sanofi, Novo Nordisk, Lilly, Dexcom, Insulet, Tandem Diabetes Care, and others.

Shah V. Beyond Type 2: Evaluating GLP-1 Use in Type 1 Diabetes and Obesity. Presented at the American Association of Clinical Endocrinology Annual Meeting 2026 in Las Vegas, NV. April 22-24, 2026.

Podcasts

Viral Shah, MD, joins the show to break down his AACE 2026 presentation on the benefits of using GLP-1 RAs in patients with T1D.

Endocrinology

The HCPLive endocrinology page is a comprehensive resource for clinical news and insights on endocrine system conditions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for diabetes, hormonal disease, and more.

Type 1 Diabetes

Type 2 Diabetes

Obesity Management

Obesity Management condition center page, resources on the topics of medical news and expert insight into clinical weight management can be found. Content includes articles, interviews, videos, podcasts, and breaking news on obesity research, treatment, and drug development.

podcasts page features a feed of medical news and interview podcast series, including DocTalk, Lungcast, Derm Discussions, and Heart Trials.

Diabetes Dialogue

Diabetes Dialogue: Technology, Therapeutics, & Real-World Perspectives is a monthly podcast hosted by Diana Isaacs, PharmD, and Natalie Bellini, DNP, aimed at providing a regular roundup of the latest clinically applicable insights across diabetes and metabolic diseases, with a focus on leveraging technology to improve care.

Conference

 conference coverage page features articles, videos, and expert-led live coverage from major medical meetings throughout the year.

Strategic Alliance Partnership

David Kass, MD, is the Abraham and Virginia Weiss Professor of Cardiology at the Johns Hopkins University School of Medicine.

HFpEF Myocardial Dysfunction May Be Reversible With Weight Loss

Findings from a Johns Hopkins investigation suggest that cardiomyocyte dysfunction seen in heart failure with preserved ejection fraction (HFpEF) and severe obesity may not be permanent, with weight loss associated with measurable recovery in contractile function at the cellular level.

HCPLive spoke to senior study investigator, David Kass, MD, the Abraham and Virginia Weiss Professor of Cardiology at the Johns Hopkins University School of Medicine.

 to learn more about the findings of severe obesity linked to distinct myocardial dysfunction in HFpEF.

Weight loss linked to improved cardiomyocyte function

To determine whether obesity-associated myocardial dysfunction is fixed or modifiable, investigators examined cardiomyocyte function in a subgroup of patients with HFpEF who underwent weight loss therapy, primarily using GLP-1 receptor agonists, over a median of 1.5 years.

In 16 patients with a baseline BMI of approximately 39 kg/m², reductions in body weight were associated with improved cardiomyocyte contractile performance. Those who lost at least 10% of body weight demonstrated near-normal peak force generation in isolated myocardial cells.

Kass said the improvement was consistent at the cellular level.

“In a subgroup of patients who underwent weight loss, those changes in muscle contraction improved, suggesting that this may be reversible with weight reduction,” Kass explained.

These findings suggest that at least some of the contractile impairment observed in HFpEF with obesity is not fixed structural damage but may reflect dynamic, modifiable signaling changes within cardiomyocytes.

Mechanistic basis: phosphorylation of sarcomeric proteins

To understand the biological basis for reversibility, investigators focused on the sarcomere, the contractile unit of the cardiomyocyte responsible for generating force through coordinated actin–myosin interactions.

Rather than differences in protein abundance, the key distinction between groups appeared to involve post-translational modification—specifically phosphorylation, a process in which phosphate groups modify protein function by altering charge and protein–protein interactions.

Kass described phosphorylation as a key regulator of normal muscle function. Phosphorylation is a common modification where a phosphate group is added to a protein, altering its charge and, in turn, can affect how the protein function

In HFpEF patients with severe obesity, investigators identified increased phosphorylation of cardiac troponin I at a site not typically phosphorylated under normal conditions. Importantly, this modification increased progressively with BMI and was not present in non-failing controls or less-obese HFpEF patients.

“A molecule called troponin I—stands for inhibitory troponin—showed up, and it had a phosphorylation at a particular site that is normally not there,” Kass noted. “The higher the body mass index, the more of this phosphorylation.”

Functionally, experimental modeling showed that mimicking this phosphorylation state reduced cardiomyocyte contractility, while enzymatic removal of phosphate groups improved force generation, supporting a potentially reversible signaling mechanism.

A reversible signaling pathway rather than fixed structural damage

These findings suggest that at least part of the myocardial dysfunction in HFpEF with obesity may be driven by dynamic biochemical signaling rather than irreversible structural remodeling.

In this framework, weight loss may improve cardiomyocyte function by altering upstream metabolic and inflammatory pathways that regulate sarcomeric phosphorylation states, rather than directly modifying contractile proteins themselves.

Kass emphasized that identifying the upstream kinase responsible for troponin I phosphorylation is a key next step, noting that such enzymes are often druggable targets.

Implications for HFpEF treatment in obesity

The data raise the possibility that HFpEF associated with severe obesity may represent a partially reversible cardiomyopathy at the cellular level, with improvements in body weight translating into measurable improvements in myocardial contractile function.

While mechanistic uncertainty remains, the authors suggest that therapies targeting weight reduction—and potentially the signaling pathways regulating sarcomeric phosphorylation—may represent a future avenue for treatment in this HFpEF phenotype.

Editor’s Note: Kass reports no relevant disclosures.

Scientists find people with severe obesity and heart failure have weakened heart muscle contractions. Weight loss may reverse this condition. EurekAlert! Published April 23, 2026. Accessed April 24, 2026. 

https://www.eurekalert.org/news-releases/1124709

Jani VP, Rhodehamel M, Fenwick AJ, et al. Severe obesity in human HFpEF alters contractile protein function and organization. 

Kass explains recent findings from a study that suggest myocardial dysfunction in HFpEF may be reversible with weight loss. 

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

Heart Failure

The HCPLive heart failure page is a resource for medical news and expert insights on HF. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for heart disease, reduced and preserved ejection fraction, and more.

HFpEF Myocardial Dysfunction May Be Reversible With Weight Loss, With David Kass, MD

Eingun James Song, MD, is the director of clinical research for Frontier Dermatology. 

Atopic Dermatitis

Atopic Dermatitis condition center page, audiences can find a variety of coverage mediums for medical news and updates, including articles, video interviews, podcasts, and breaking news on dermatitis research, treatment, and drug development.

OX40 for Atopic Dermatitis: A Target at a Crossroads

Kass explains 2 distinct biological subgroups discovered in HFpEF and how they relate to a paradigm shift. 

Severe Obesity Linked to Distinct Myocardial Dysfunction in HFpEF

Elizabeth Bauer, MD, joins the show to discuss her AACE 2026 presentation on key updates in obesity management and nutrition.

Diabetes Dialogue: Nutrition, Medication, and Treatment in Obesity With Elizabeth Bauer, MD

Auchus discusses the 2-year results from CAHtalyst Adult, highlighting the substantial retention rates over the open-label extension period.

Crinecerfont Reduces Glucocorticoid Doses in CAH, With Richard Auchus, MD, PhD

Jagbir Gill, MD, MPH, is an Associate Professor of Medicine in the Division of Nephrology at the University of British Columbia and Medical Director of the Kidney Transplant Program at St. Paul’s Hospital in Vancouver. He also serves as Medical Director of Data and Quality for BC Transplant, President of the Canadian Organ Replacement Register Board of Directors, and as Treasurer for the Canadian Society of Transplantation.

Gill describes how storytelling and patient representation can build trust and education in Indigenous populations regarding transplantation. 


Chronic Kidney Disease

Transplant Care Strategies to Target Mistrust, Close Gaps in Indigenous Communities

Scott Isaacs, MD, is an Adjunct Assistant Professor of Medicine at Emory University. He currently serves as Immediate Past President of the American Association of Clinical Endocrinology (AACE).

Isaacs explains how prediabetes care is shifting toward early intervention, risk stratification, and prevention of cardiometabolic disease, not just progression to diabetes.

Breaking the ‘Watch and Wait’ Model in Prediabetes Care, With Scott Isaacs, MD

Oksana Hamidi, DO, is an associate professor in the division of endocrinology and metabolism at the University of Texas Southwestern Medical Center.

Hamidi reviews 2-year CAHtalyst data showing crinecerfont enabled sustained glucocorticoid reductions to physiologic range in adults with classic congenital adrenal hyperplasia.

CAHtalyst Adult: Sustained GC Reduction With Crinecerfont in CAH, With Oksana Hamidi, DO

Chelsie Derman is an associate editor for 

who covers allergy and  psychiatry. She joined MJH Life Sciences in September 2023 after graduating from The College of New Jersey with a bachelor’s degree in journalism and professional writing. In her free time, she enjoys creative writing and reading.

Twin phase 3 trials show triple therapy with budesonide–glycopyrronium–formoterol improves FEV1 and lowers severe exacerbation rates in patients with uncontrolled asthma on ICS–LABA


Pulmonology

Infectious Disease condition center page is a comprehensive resource for clinical news and insights on respiratory health. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for asthma, COPD, interstitial lung disease, COVID-19, and more.

Asthma

The HCPLive asthma page is a comprehensive resource for clinical news and insights on asthmatic disease. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for allergic and severe asthma, and more.

BGF Triple Therapy Improves Lung Function in Phase 3 Uncontrolled Asthma Controls

Christopher G. Bunick, MD, PhD, is an associate professor of dermatology at Yale University School of Medicine.

Christopher Bunick, MD, PhD, and colleagues conducted a review bispecific and trispecific antibodies in atopic dermatitis.

Bispecific and Trispecific Antibodies in Atopic Dermatitis, With Christopher Bunick, MD, PhD

Linda DiMeglio, MD, MPH, joins the show to discuss the growing movement towards screening and testing for T1D at an early stage.

Latest News

Single-Dose Lonvo-z Cuts HAE Attacks by 87% in Phase 3 Trial, With Aleena Banerji, MD

The HCPFive: Top News for Healthcare Providers from the Week of 04/19

EVERLAST-A: Positive Phase 2a Data Observed for ORKA-001 in Psoriasis at Week 16

Diabetes Dialogue: Expanding GLP-1 Usage Into Type 1 Diabetes With Viral Shah, MD

HFpEF Myocardial Dysfunction May Be Reversible With Weight Loss, With David Kass, MD