A clip from the inaugural episode of ABCs in Dermatology exploring what drew our hosts to dermatology

ABCs in Dermatology: Our Hosts' Journeys to Dermatology

 introduces co-hosts Lindsay Ackerman, MD, and Chris Bunick, MD, PhD, through a discussion that reflects the diverse pathways that ultimately lead clinicians into the field. In the opening conversation, both hosts share how early academic exposure, clinical experiences, and mentorship shaped their decisions to pursue dermatology, offering insight into the intellectual and human elements that define the specialty.

Bunick describes how his background in molecular research, specifically in nucleotide excision repair and the role of the XPC protein in DNA damage, first connected him to dermatology through its relevance to skin cancer biology. Although his initial impressions of the field were not favorable, a later clinical rotation and the influence of a mentor specializing in cutaneous T-cell lymphoma reframed his perspective, highlighting the combination of scientific depth and patient impact that dermatology offers.

Ackerman’s path similarly began with early research exposure, working in a cutaneous oncology clinic studying melanoma susceptibility during her undergraduate years. Her experience in medical school further broadened her perspective, as she explored multiple specialties before recognizing dermatology’s ability to integrate elements of internal medicine, surgery, and longitudinal patient care. She emphasizes the specialty’s unique capacity to address a wide spectrum of disease while maintaining a strong connection with patients through visible and tangible manifestations of illness.

Together, their discussion underscores the role of mentorship, clinical exposure, and interdisciplinary interest in shaping careers in dermatology, while also highlighting the field’s balance of complexity, procedural skill, and patient-centered care.

Relevant disclosures for Bunick include AbbVie, South Beach Symposium, Almirall, Apogee Therapeutics, Arcutis Biotherapeutics, Daiichi Sankyo, Eli Lilly, LEO Pharma, US, Novan, Novartis, Ortho Dermatologics, Palvella Therapeutics, Pfizer Inc., Sanofi, Sun Pharmaceutical Industries Ltd., Timber Pharmaceuticals, and UCB. Relevant disclosures for Ackerman include AbbVie, Alumis, Amgen, Arcutis, Beiersdorf, Boehringer Ingelheim, Bristol Myers Squibb, Dermavant, Galderma, L'Oréal, Novartis, Sun Pharmaceutical, and UCB.

Videos

Hosts reveal how research, mentors, and clinic rotations spark a passion for skin disease and what makes dermatology unique.

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Balázs Szigeti, PhD, from the Translational Psychedelic Research Program at University of California San Francisco (UCSF)

 Psychedelics Expand Options, Not Efficacy, in Depression Care, With Balázs Szigeti, PhD

As interest in psychedelic-assisted therapy (PAT) continues to grow, new data suggest its role in 

 treatment may be more complementary than transformative.

, Balázs Szigeti, PhD, from the Translational Psychedelic Research Program at the University of California, San Francisco (UCSF), discussed how clinicians should interpret recent findings showing no significant difference in core depressive symptom improvement between PAT and traditional antidepressants under comparable unblinding conditions.

Rather than positioning PAT as a replacement for existing therapies, Szigeti framed it as an additional tool in the treatment armamentarium. Differences in adverse event profiles, treatment logistics, and patient preferences will likely shape its clinical role.

“It's just one more tool that the clinician can use to treat their patients,” he said.

In the meta-analysis of 24 studies, PAT and open-label antidepressants brought comparable reductions in depression scores, with an estimated difference of 0.3 points on the Hamilton Depression Rating Scale (HAM-D) (95% confidence interval [CI], −1.39 to 1.98; 

 =.73). These findings challenge earlier beliefs that psychedelics may provide substantially greater efficacy than standard antidepressants, which had fueled enthusiasm in the psychiatry field.

According to Szigeti, the study also adds methodological clarity to a debate increasingly shaped by concerns over trial design, particularly functional unblinding. Earlier trials on MDMA-assisted therapy for PTSD largely overlooked this issue, but scrutiny intensified following the US Food & Drug Administration (FDA) decision. Szigeti noted that his team’s meta-analytic approach offers a way to address these biases without relying on elusive “active placebo” controls.

Beyond symptom reduction, Szigeti highlighted the need to expand how treatment success is measured. Functional outcomes, such as quality of life, daily functioning, and overall well-being, remain underrepresented in antidepressant trials.

“Psychedelic studies started to collect such data because, from anecdotal evidence, there are indications that psychedelics improve in those domains as well,” Szigeti said. “The issue is that, because they are not there with the traditional antidepressant trial[s], we just have no basis of comparison.”

Szigeti identified the gap between clinical trials and real-world use as a critical challenge. Antidepressant studies often assess outcomes at 8 weeks, despite long-term use in practice. He expects this disconnect to be even more pronounced with psychedelics, given the added psychotherapy component.

“It always struck me as something weird that we are putting millions and billions of dollars into clinical research, but very often how these medicines are used in real life has nothing to do with how we have tested them in clinical research,” Szigeti said. “The real question is how the efficacy is going to look once it is practiced in real life, not in the highly constrained clinical research environment.”

Williams ZJ, Barnett H, Szigeti B. Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions: A Systematic Review and Meta-Analysis. 

Findings suggest psychedelics match antidepressants for symptom relief, with future research needed on real-world use and functional outcomes.

Psychiatry

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Major Depressive Disorder

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Psychedelics Expand Options, Not Efficacy, in Depression Care, With Balázs Szigeti, PhD

Patrick Campbell is the editorial director of HCPLive. Patrick has spent years spearheading coverage surrounding cardiometabolic health and rheumatic disease for MJH Life Sciences. Before joining MJH Life Sciences in 2019, he spent time as a beat reporter and/or multimedia specialist with the Pocono Record, Star News Group, and NJ Advance Media. He is the executive producer for multiple HCPLive podcasts, including Diabetes Dialogue, Don't Miss a Beat, Kidney Compass, Medical Ethics Unpacked, The Medical Sisterhood, and Skin of Color Savvy. 


Follow him on Twitter @RealPatCampbell or reach him via email at PCampbell@mjhlifesciences.com.

Stopping GLP-1 receptor agonist therapy, even briefly, is associated with a measurable increase in risk of 

, according to a cohort study of more than 300,000 published in 

The findings add important clinical context to the widely documented problem of GLP-1 discontinuation and suggest the cardiovascular consequences of stopping treatment extend well beyond weight regain.¹

“There is enormous exuberance about starting GLP-1 drugs, but not nearly enough attention to what happens when people stop,” said lead investigator Ziyad Al-Aly, MD, a Washington University in St. Louis School of Medicine clinical epidemiologist and chief of the Research and Development Service at the VA Saint Louis Health Care System. “Many quit after a few months because of cost, side effects or shortages. When they stop, it’s not just weight that comes back; they experience a resurgence in inflammation, blood pressure, and cholesterol. Weight regain is visible; the metabolic reversal is not.”

Leveraging VA Data to Understand GLP-1 Benefits

The analysis used a target emulation trial design drawing on data from 333,687 US veterans with type 2 diabetes. Researchers compared 132,551 patients prescribed GLP-1 receptor agonists, including semaglutide and tirzepatide, with 201,136 patients prescribed sulfonylureas. Treatment status was evaluated every 6 months over a 3-year follow-up period. The primary outcome was a composite of major adverse cardiovascular events, including myocardial infarction, stroke, and death.¹

Continuous GLP-1 use over the full 3-year period was associated with the greatest cardiovascular benefit, corresponding to an 18% reduction in major adverse cardiovascular events compared with sulfonylurea use, or 4 fewer events per 100 patients over 3 years. Benefit was also observed among patients who used GLP-1s for 2 to 2.5 years before discontinuing (7% and 15% risk reduction, respectively). Patients who stopped within 18 months saw no significant risk reduction at the end of follow-up compared with the sulfonylurea group.¹

Interruptions followed by resumption of treatment also diminished benefit. Compared to continuous use, a gap of 6 months before restarting was associated with a 4% to 8% increase in cardiovascular risk relative to uninterrupted therapy. Discontinuation of 1 or 2 years without resumption corresponded to a 14% or 22% increased risk, respectively, compared to staying on the drug. Restarting treatment restored some protection, a finding the investigators characterized as evidence of a lasting effect from the period of discontinuation.¹

Over the course of the study, 26% of GLP-1 users stopped treatment entirely and approximately 23% experienced an interruption of 6 months or more before resuming.¹

Clinical Implications for Adherence and Access

The study is observational and subject to limitations inherent in real-world claims-based data, including potential confounding by indication and differences in baseline characteristics between GLP-1 and sulfonylurea users. The cohort was drawn exclusively from the VA population, which skews male and older, limiting generalizability. Additionally, the use of sulfonylureas as the comparator group, rather than placebo, shapes the magnitude of relative risk estimates.

The investigators called for health systems to treat GLP-1 adherence as a primary clinical outcome, including proactive side effect management, patient counseling about the long-term nature of treatment, and structural approaches to addressing the cost barriers that drive discontinuation.¹

“Health systems need plans in place to help people continue their medication indefinitely, recognizing that GLP-1s treat chronic conditions,” Al-Aly added. “That includes proactive management of side effects, candid conversations about the long-term nature of treatment, infrastructure to identify and support patients at risk of stopping and addressing the cost barriers that make GLP-1 therapy unsustainable for many.”

Xie Y, Choi T, Al-Aly Z. GLP-1RA discontinuation and risks of major adverse cardiovascular events in adults with type 2 diabetes: a target emulation trial. 

 2026;5(1):e002150. doi:10.1136/bmjmed-2025-002150

Washington University School of Medicine in St. Louis. Stopping GLP-1 drugs can quickly erase cardiovascular benefits. EurekAlert! Published March 18, 2026. Accessed March 20, 2026. 

https://www.eurekalert.org/news-releases/1120133

Articles

Stopping GLP-1 receptor agonists in adults with type 2 diabetes was associated with attenuation or loss of cardiovascular risk reduction, with even brief interruptions linked to measurable increases in major adverse cardiovascular events. In a VA-based target trial emulation comparing GLP-1RAs with sulfonylureas, continuous 3-year therapy conferred the largest benefit, while early discontinuation showed no significant advantage. Treatment gaps followed by resumption only partially restored protection, implying a durable adverse impact of interruption. Findings emphasize adherence, access, and long-term management.

GLP-1 discontinuation increases major adverse cardiovascular event risk in type 2 diabetes, highlighting the need for continuous therapy to sustain cardiometabolic benefit.

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

Atherosclerotic Cardiovascular Disease

GLP-1 Discontinuation Tied to Loss of Cardiovascular Protection  

Victoria Johnson joined MJH Life Sciences in 2020 and has written for NeurologyLive, CGTLive, and is now an assistant managing editor for HCPLive and RheumatologyLive. She doesn’t have enough time for her numerous hobbies. You can reach her at vjohnson@mjhlifesciences.com.

 is, at its core, a story of expanding possibility — and expanding complexity. Beginning with omalizumab's approval in 2003 and accelerating dramatically over the past decade, the field has moved from a single IgE-targeting agent that required allergy consultation to a therapeutic landscape where pulmonologists now independently select among seven approved biologics spanning 5 distinct mechanisms. Mepolizumab established the IL-5 pathway as a durable target in 2015; dupilumab's dual IL-4/IL-13 blockade arrived for asthma in 2018 and redefined expectations for both lung function improvement and steroid sparing¹; and tezepelumab's 2021 approval for any eosinophil level began to challenge the biomarker-centric framework that had organized biologic prescribing since its inception.² Most recently, dupilumab's landmark 2023 FDA approval for COPD with type 2 inflammation — the first biologic ever cleared for that indication — and mepolizumab's subsequent chronic obstructive pulmonary disease (COPD) approval following the MATINEE trial³ have opened a new frontier, extending precision immunotherapy to a disease that clinicians had long assumed was beyond its reach. And with depemokimab's approval for severe eosinophilic asthma in late 2024,⁴ offering a 6-month dosing interval that reframes the adherence calculus entirely, the pace of development shows no sign of slowing.

Yet the expansion of the toolkit has not been matched by equivalent clarity about how to use it. Which biologic for which patient — and when, at what biomarker threshold, and in the face of which insurance barriers — are questions that clinical trial data can inform but cannot fully resolve. It is in that practical space that 

 convened a virtual expert forum moderated by MeiLan Han, MD MS, is a Professor of Medicine and Chief of the Division of Pulmonary and Critical Care at the University of Michigan Health. Together, they worked through the evidence base, traded candid assessments of which drugs they actually use and why, and confronted the practical obstacles that no trial protocol accounts for: J-code delays on newly approved agents, step therapy requirements that have pushed some panelists to stop prescribing certain biologics altogether, and the persistent challenge of patients who arrive having already accumulated a damaging history of repeat oral corticosteroid courses before a specialist ever sees them.

“I feel like the biggest issue for me, so we have 2 Urgent Cares right next to my office, and they're actually part of our healthcare system. And if patients can't get in to see me, they'll usually go see the Urgent Care, and Urgent Care hands out prednisone like candy. Like, you have a cough, here's prednisone. They have a lot much lower threshold to prescribe,” a panelist said.

Dupilumab dominated biologic selection preferences across both asthma and COPD — driven by ease of home administration, familiarity, and a perception among many panelists that it simply performs better in clinical practice than the IL-5 agents, particularly for patients with nasal polyp and eczema comorbidities. IL-5 agents retain a clear niche for very high eosinophil counts — several panelists named 600 to 800 cells/µL as the threshold where they lean toward rapid eosinophil depletion — with mepolizumab the preferred IL-5 among most, given recurring reports of end-of-cycle breakthrough symptoms with benralizumab that have led some panelists to dose it every six rather than eight weeks using office samples. Tezepelumab's positioning as a biomarker-agnostic agent has been complicated by step therapy insurance requirements and what one panelist called a "disingenuous" marketing pivot after its initial launch, though the moderator noted that 3–4 patients who failed dupilumab and benralizumab responded to tezepelumab — all non-TH2 asthma — and argued that broader familiarity with the drug is worth building. Depemokimab, meanwhile, remains more theoretical than clinical reality for most of the group, though panelists identified adherence-challenged populations — including patients who might receive a dose at hospital discharge — as compelling future use cases.

In COPD, the discussion reflected a field gaining momentum but constrained by patient expectations and payer realities. The GOLD 2025 guidelines have incorporated eosinophil counts and T2 biomarkers into the COPD escalation algorithm,⁵ and the BOREAS and NOTUS trials for dupilumab demonstrated not only exacerbation reduction but statistically significant FEV1 improvement — a finding the panel interrogated at length, with the leading hypothesis pointing to mucus plug clearance in distal airways as the likely mechanism, supported by VESTIGE trial data and an ongoing dedicated COPD mucus plug study.⁶ Mepolizumab's COPD data from MATINEE, by contrast, showed exacerbation reduction without meaningful lung function or symptom improvement,³ creating a practical differentiation that has pushed most panelists to default to dupilumab when insurance allows — and to mepolizumab only when dupilumab is denied. The core challenge in COPD that no trial has fully resolved: patients don't always feel better even when exacerbation rates decline, making biologics a harder sell than in asthma, where the "life-changing" patient report is common. Several panelists noted off-label success with dupilumab in bronchiectasis and ABPA by coding chronic obstruction and mucus plugging — and 1 panelist anecdote of a patient who came off daytime oxygen entirely after an inadvertent off-label start underscored both the drug's potential and the limits of what approved indications currently capture.

The forum closed with a look at a pipeline that promises to keep the field moving — IL-33 inhibitors with mixed trial results but ongoing third studies, tezepelumab in COPD, emerging bispecifics, brensocatib for bronchiectasis, and ensifentrine as an inhaled dual PDE3/4 inhibitor with variable but real bronchodilatory benefit — while acknowledging the fundamental gap that remains: no biomarker equivalent to the eosinophil has emerged for the neutrophilic COPD population that current biologics cannot reach. For the clinicians in this forum, that gap is not an abstraction. It is the patient on triple therapy who keeps exacerbating, whose eosinophils are normal, and for whom the next therapeutic option does not yet exist. Until it does, the panel's consensus was clear: move patients with T2 inflammation to biologics earlier, set realistic expectations in COPD, fight insurance denials aggressively, and resist the reflex to reach for prednisone when a more durable answer is increasingly within reach.

Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. 

. 2018;378(26):2486-2496. doi:10.1056/NEJMoa1804092

Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. 

. 2021;384(19):1800-1809. doi:10.1056/NEJMoa2034975

Eger K, Hashimoto S, Braunstahl GJ, et al. Mepolizumab for eosinophilic COPD with exacerbations (MATINEE). 

. 2024;391(1):21-31. doi:10.1056/NEJMoa2401300

Wechsler ME, Menzies-Gow A, Brightling CE, et al. Evaluation of the efficacy and safety of depemokimab in patients with severe asthma with an eosinophilic phenotype (SWIFT-1 and SWIFT-2). 

. 2024;404(10471):2373-2385. doi:10.1016/S0140-6736(24)02063-4

Global Initiative for Chronic Obstructive Lung Disease. 

Global Strategy for Prevention, Diagnosis and Management of COPD: 2025 Report

Bhatt SP, Rabe KF, Hanania NA, et al; BOREAS Investigators. Dupilumab for COPD with type 2 inflammation indicated by eosinophil counts. 

. 2023;389(3):205-214. doi:10.1056/NEJMoa2303951

Biologic therapy for airway disease has rapidly diversified from IgE targeting to seven agents across five mechanisms, now extending into COPD with type 2 inflammation. Clinical choice is increasingly shaped less by trial hierarchies than by real-world constraints: delayed billing codes, step therapy, and late referral after repeated oral corticosteroid exposure. Dupilumab is often favored for asthma and COPD given home administration, perceived superior effectiveness, and comorbidity synergy, while IL-5 agents remain preferred for very high eosinophils. Persistent unmet need remains for neutrophilic COPD.

Clinicians compare newest asthma/COPD biologics, highlighting dupilumab’s edge, biomarker shifts, and insurance barriers shaping real-world use.

COPD

COPD condition center page, resources on the topics of medical news and expert insight into chronic obstructive pulmonary disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on COPD research, treatment, and drug development.

Pulmonology

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COPD Biologics in Practice: Exacerbation Reduction is No Longer Enough

Linda Stein Gold, MD, is a dermatologist at Henry Ford Health. 

Key Points on Icotrokinra Following FDA Approval for Psoriasis, With Linda Stein Gold, MD

 editorial team about icotrokinra (Icotyde) and its recent approval by the US Food and Drug Administration (FDA) for moderate to severe plaque psoriasis in adult and adolescent patients aged 12 and older weighing at least 40 kg who are candidates for systemic therapy or phototherapy.

Stein Gold addressed the gap this medication fills. Icotrokinra is the first oral targeted peptide to selectively block the interleukin (IL)-23 receptor, introducing a new mechanistic class to the psoriasis armamentarium. In her responses, Stein Gold framed the approval as addressing a longstanding unmet need in the oral treatment space.

“I think we've had a big unmet need for our moderate to severe plaque psoriasis patients,” Stein Gold explained. “We have great biologic agents, we have good topical agents, but the oral space really needed something that had very good efficacy, very good safety, and very good tolerability. So I think that this drug fills that need.”

While biologics and topical agents have served those living with moderate to severe psoriasis reasonably well, Stein Gold noted the oral category had been missing an option. In her view, the treatment delivers on all efficacy, safety, and tolerability, producing efficacy she described as comparable to a biologic agent while preserving the convenience and tolerability expected of an oral medication. That profile, she said, positions it well for any patient who needs systemic therapy.

She was also asked about the efficacy and safety picture for dermatologists weighing icotrokinra against agents they already know. In her response, Stein Gold pointed to the breadth and design of the ICONIC phase 3 program as the basis for confidence. The drug was studied not only against a placebo but also head-to-head against deucravacitinib, which she identified as having previously demonstrated the best efficacy record among oral medications in this space.

“What we see is the drug starts to kick in fairly rapidly,” Stein Gold said. “We see a nice steep slope, and there's good separation from the placebo, but also from deucravacitinib, as early as week four.”

This separation was described as continuing across the full 16-week primary endpoint period. Approximately 70% of those assessed attained clear or almost clear skin by the 16-week mark, with this level of response holding through long-term follow-up.

Stein Gold also described the adolescent data as good news, noting, for pediatric dermatologists managing patients right at the approved threshold of 12 years and 40 kg, icotrokinra actually performed better in adolescents than it did in adults. This was noted, while the drug maintained the same strong tolerability and safety profile seen across the broader trial population.

The once-daily oral dosing was also highlighted by Stein Gold as a practical advantage for this age cohort. She noted many adolescent patients had been and would be relieved not to require an injection.

Disclosures: Stein Gold has reported serving as an investigator, advisor, or speaker for AbbVie, Amgen, Arctis, Bristol Myers Squibb, Dermavant, Eli Lilly, Johnson & Johnson, Novartis, Pfizer, and UCB. AWA has served as a research investigator, scientific advisor, or speaker to AbbVie, Amgen, Arcutis, BMS, Boehringer Ingelheim, Dermavant Sciences, Eli Lilly, Galderma, Incyte, Johnson & Johnson, Leo Pharma, Novartis, Parexel, Pfizer, Regeneron, Sanofi, Takeda, and UCB. RB is an advisory board member, consultant, speaker, investigator for, or received honoraria or grants from AbbVie, Alumis, Amgen, AnaptysBio, Arcutis, BMS/Celgene, Eli Lilly, Johnson & Johnson, LEO Pharma, Organon, Nimbus, Takeda, UCB, VentyxBio, Vyne, Xencor, and Zurabio, and is also an employee and shareholder of Innovaderm Research.

Campbell P. Icotrokinra, an Oral Il-23 Inhibitor, Receives FDA Approval for Psoriasis. HCPLive. March 18, 2026. Accessed March 20, 2026. 

https://www.hcplive.com/view/icotrokinra-receives-fda-approval-for-psoriasis

Johnson and Johnson. FDA approves ICOTYDE (icotrokinra), the first and only targeted oral peptide IL-23 receptor antagonist, for the treatment of moderate-to-severe plaque psoriasis. Press release. Published March 18, 2026. Accessed March 20, 2026. 

https://www.jnj.com/media-center/press-releases

Linda Stein Gold, MD, shares her perspective on the clinical significance of icotrokinra's FDA approval and what dermatologists need to know.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

Meta-analysis shows psychedelic-assisted therapy offers similar symptom improvement to open-label antidepressants under equal unblinding conditions.


Psychedelic Therapy Matches Efficacy of Antidepressants in MDD, With Balázs Szigeti, PhD

Abigail Brooks is an assistant managing editor for 

She joined MJH Life Sciences in August 2023 shortly after graduating from Monmouth University where she earned her BA in Communication with a concentration in Public Relations/Journalism and later an MA in Interactive Digital Media. She enjoys traveling, running, and reading books. She can be reached at abrooks@mjhlifesciences.com.

The approval is based on results from the STEP UP trial program showing substantial weight loss in adults with obesity. 

FDA News

Obesity Management

Obesity Management condition center page, resources on the topics of medical news and expert insight into clinical weight management can be found. Content includes articles, interviews, videos, podcasts, and breaking news on obesity research, treatment, and drug development.

FDA Approves Higher Dose Semaglutide (Wegovy HD) Injection 7.2 mg for Obesity

Doug Simonetto, MD, is a Mayo Clinic transplant hepatologist.

AI-enabled ECG may help detect liver disease earlier, offering a new path to close diagnostic gaps and shift toward preventive hepatology in clinical practice.

Hepatology

Improving Early Liver Disease Diagnosis With AI ECG, With Doug Simonetto, MD

Allergist-immunologist at Yale New Haven Hospital

Su described how NNAALs drive management decisions in pregnancy and post partum care.

Conference

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Allergy

Allergy condition center page is a comprehensive resource for clinical news and insights on allergic and inflammatory diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for food and seasonal allergies, as well as allergic asthma and related conditions.

Non-Narcotic Analgesic Allergy Labels in Pregnancy Drive Suboptimal Care and Adverse Outcomes, With Chang Su, MD

The first-in-class GIP, GLP-1 and glucagon triple hormone receptor agonist delivered superior A1C reduction and weight loss at 40 weeks in people with type 2 diabetes.

Endocrinology

The HCPLive endocrinology page is a comprehensive resource for clinical news and insights on endocrine system conditions. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for diabetes, hormonal disease, and more.

Type 2 Diabetes

Retatrutide Delivers A1C Reduction, Weight Loss in Phase 3 TRANSCEND-T2D-1 Trial

Maya Clark Cutaia, PhD, RN, is the inaugural Evelyn Lauder Associate Dean for Nurse Practitioner Programs and Professor at the Hunter-Bellevue School of Nursing at Hunter College.

An expert breaks down how poverty, limited healthcare access, and geographic barriers delay CKD diagnosis, reduce transplant access, and widen health disparities, and what clinicians can do about it.


Neighborhood Disadvantage and Its Downstream Effects on Equitable Kidney Care, With Maya Clark Cutaia, PhD, RN

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

This preview highlights key data to watch out for during the 2026 American Academy of Dermatology (AAD) meeting in Denver, Colorado.

AAD 2026 Preview: Late Breaking Data to Watch

Experts examine how the guidelines represent the evidence base for each step-up agent and address the limited role of laboratory testing in driving treatment decisions.

Interpreting the Treatment Algorithm: Evidence Levels, Diagnostic Workup, and the Stepwise Framework 

Accelerated 5×5 rTMS delivers comparable outcomes to standard protocols, offering faster treatment with key tradeoffs in cost, access, and response timing.

Accelerated rTMS Matches Conventional Protocol in TRD, With Andrew Leuchter, MD

Experts discuss how clinicians can use patient preferences, comorbidities, route of administration, and access considerations to guide decisions.

Latest News

ABCs in Dermatology: Our Hosts' Journeys to Dermatology

Psychedelics Expand Options, Not Efficacy, in Depression Care, With Balázs Szigeti, PhD

GLP-1 Discontinuation Tied to Loss of Cardiovascular Protection

COPD Biologics in Practice: Exacerbation Reduction is No Longer Enough

Key Points on Icotrokinra Following FDA Approval for Psoriasis, With Linda Stein Gold, MD