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The 2016 CDC guidelines led to significant decreases in opioid prescriptions and an increase in pain-related healthcare utilization for people with sickle cell disease. 


CDC Opioid Guidelines Linked to Negative Consequences in Sickle Cell Disease

An ancillary study of the phase 2 HOPE-KIDS 1 trial revealed voxelotor is associated with reduced sickling and hemolysis in children with SCD. 

Voxelotor Benefits Red Blood Cell Functionality in Pediatric Sickle Cell Disease

A meta-analysis revealed a higher prevalence of abnormal ECG findings in individuals with SCD compared to those without the disease.

Abnormal ECG Findings Prevalent Among People with Sickle Cell Disease 

Voxelotor decreases oxygen extraction fraction and cerebral blood flow towards levels observed in healthy children.

Voxelotor Improves Cerebral Hemodynamic Parameters in Pediatric Sickle Cell Disease

No concerning patterns of long-term or increasing opioid use were observed within 3 years after first opioid prescription in opioid-naive children with SCD.

Children with Sickle Cell Disease Show No Alarming Trends After Opioid Use

Hearing loss was more prevalent among children and adults with sickle cell disease and its traits compared to matched controls with normal hemoglobin.

Hearing Loss Prevalence High in Children, Adults with Sickle Cell Disease  

Over the study period, pain screening procedures were integrated within routine clinical visits and providers’ workflow in sickle cell disease care. 

Clinical Pain Screening Proves Feasible in Pediatric Sickle Cell Disease 

A systematic review combined with a pair of case studies suggest men who discontinue the front-line treatment for conditions like polycythaemia vera may improve their fertility.

Hydroxyurea Discontinuation May Improve Sperm Levels in Hematologic Patients

Presented at ASH 2023, findings of a new study showed patients with sickle cell disease and venous thromboembolism have longitudinal worsening of left ventricular diastolic and right-sided cardiac function.

Sickle Cell Disease with Venous Thromboembolism Linked to Higher Mortality

Presented at ASH 2023, opioid use disorder in sickle cell disease patients with vaso-occlusive is associated with a longer hospital stay and greater cost.

Opioid Use Disorder in Sickle Cell Patients with Vaso-Occlusive Crisis Linked to Greater Cost

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