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Turning the Tide: Early PCSK9 Intervention Post-ACS - Episode 10

Safety Data on PCSK9i Inclisiran

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Panelists discuss how inclisiran’s sustained LDL-lowering effect, safety profile, and ease of biannual administration position it as a transformative therapy for overcoming persistent gaps in post-ACS event care, as highlighted by real-world findings from the VICTORION-INCEPTION study.

The discussion underscores the persistent challenge of achieving optimal low-density lipoprotein (LDL) control in routine clinical practice, particularly after acute cardiovascular events. Despite established guidelines, many patients fail to reach target LDL levels due to systemic barriers in usual care settings. This reinforces the need for a paradigm shift in lipid management. Inclisiran, with its sustained LDL-lowering capability and infrequent dosing schedule, emerges as a promising upstream therapy that could reshape how clinicians approach high-risk patients during the most vulnerable period following an acute coronary syndrome (ACS) event.

The VICTORION-INCEPTION study offers real-world insight by comparing inclisiran plus usual care to usual care alone. In the usual care group, LDL levels often remained unchanged, reflecting the limitations of current strategies. In contrast, inclisiran delivered significant LDL reductions and maintained those levels over time. This shift in thinking—from reactive to proactive LDL management—could have profound implications for both patient outcomes and population health. It’s especially relevant for high-risk groups that typically struggle with adherence and continuity of care, making inclisiran’s biannual in-office administration a practical solution.

From a safety standpoint, inclisiran has demonstrated a strong profile across its clinical development program. Serious adverse events have been rare, with the most common being mild injection site reactions. Notably, long-term follow-up from the ORION trials (up to 7 years) has shown no increase in adverse events compared with control groups. This consistency supports inclisiran’s use in clinical practice and reassures health care providers about its safety, even while targeting PCSK9 at the genetic level. The evidence positions inclisiran as a transformative tool in cardiovascular risk reduction.

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