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Turning the Tide: Early PCSK9 Intervention Post-ACS - Episode 2

The Risk of a Recurrent Event After ACS

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Panelists discuss how patients with recent acute coronary syndrome (ACS) are at an elevated risk for recurrent cardiovascular events due to factors such as plaque instability, inflammation, endothelial dysfunction, and residual risk despite treatment, emphasizing the need for intensive secondary prevention strategies.

The discussion focuses on the critical difference between primary and secondary prevention in cardiovascular care, particularly for patients who have already experienced an acute coronary syndrome (ACS) event. Once a patient has had a cardiovascular event, their risk of experiencing another event is significantly higher. This is because the factors that contributed to the initial event—such as plaque rupture or thrombotic processes—do not disappear after treatment or hospitalization. These ongoing risk factors make the period immediately following an ACS event especially high risk.

The first year after an ACS event is particularly vulnerable for patients, and this time frame is crucial for preventing a recurrence. Research has shown that the risk of a second event is highest in the first 3 to 6 months following the initial incident. During this period, patients are still at risk from the underlying causes of their cardiovascular disease, meaning aggressive treatment and intervention are needed right away. Lowering LDL cholesterol, managing blood pressure, and addressing lifestyle factors like smoking cessation should be prioritized during this time.

One of the key takeaways from the discussion is the importance of early intervention in secondary prevention. For too long, there has been a focus on preventing the first event, but it’s become clear that addressing modifiable risk factors right after the initial event is equally critical in reducing the risk of further complications. By acting quickly and aggressively with treatment, we can significantly lower the chances of recurrent cardiovascular events. This requires a shift in how we approach care, especially in the immediate aftermath of an ACS event. It’s not just about treating the initial problem but about setting patients up for long-term success in managing their heart health.

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