Navigating Therapeutic Pathways and Transforming Care in ATTR-CM - Episode 11
Key Takeaways from AHA 2025 Scientific Sessions
The panel reviews key insights related to transthyretin amyloidosis therapies discussed at the AHA 2025 Scientific Sessions. They emphasize that the new data presented are largely “on the margins,” reinforcing findings already established in pivotal trials: the major disease-modifying therapies for ATTR-CM are effective and safe, and the most important mistake is not initiating any therapy once the diagnosis is confirmed. One topic highlighted from recent analyses is atrial arrhythmias in ATTR-CM. The panel notes that while patients with atrial arrhythmias often represent more advanced disease, the presence of arrhythmias does not diminish the efficacy of available treatments. The discussion also touches on renal function data, where improvements are believed to reflect better heart failure status and reduced diuretic need, rather than a direct renal effect of therapy. Overall, the panel emphasizes individualized management and careful clinical interpretation rather than one-size-fits-all assumptions.
The panel reviews key insights related to transthyretin amyloidosis therapies discussed at the AHA 2025 Scientific Sessions. They emphasize that the new data presented are largely “on the margins,” reinforcing findings already established in pivotal trials: the major disease-modifying therapies for ATTR-CM are effective and safe, and the most important mistake is not initiating any therapy once the diagnosis is confirmed. One topic highlighted from recent analyses is atrial arrhythmias in ATTR-CM. The panel notes that while patients with atrial arrhythmias often represent more advanced disease, the presence of arrhythmias does not diminish the efficacy of available treatments. The discussion also touches on renal function data, where improvements are believed to reflect better heart failure status and reduced diuretic need, rather than a direct renal effect of therapy. Overall, the panel emphasizes individualized management and careful clinical interpretation rather than one-size-fits-all assumptions.
