Advances in Primary Biliary Cholangitis: Expert Insights on Emerging Data and Key Treatment Innovations - Episode 1

Segment 1- An Overview of PBC Pathophysiology, Severity, and Burden

Published on: January 26, 2026

Aparna Goel, MD, A. Sidney Barritt IV, MD, MSCR, Lance L. Stein, MD, Frances Lee, MD

Explore expert insights on primary biliary cholangitis, focusing on symptoms, treatment innovations, and emerging clinical data for effective patient management.

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EP. 1: Segment 1- An Overview of PBC Pathophysiology, Severity, and Burden

EP. 2: Segment 2- Key Symptoms of PBC- Fatigue, Pruritus, and Bone Health

In this episode titled, “An Overview of PBC Pathophysiology, Severity, and Burden,” Aparna Goel, Lance L. Stein, A. Sidney Barritt IV, and Frances Lee highlight the key symptoms and burdens associated with primary biliary cholangitis (PBC)

Led by the moderator, the expert hepatologists examine the following critical questions:

Please provide an overview of primary biliary cholangitisand signs and symptoms of PBC (hepatic/extrahepatic).

What are the known risk factors for primary biliary cholangitis (such as female sex and age)? What do we know about the underlying reasons for these risks?

What is our understanding of underlying causes leading to a manifestation of primary biliary cholangitis?

How do you assess the severity of primary biliary cholangitis in a patient and their risk of progression?

Please discuss the burden of primary biliary cholangitis and how symptoms like fatigue and pruritus are distinct and can dramatically impact patient quality of life.

Throughout the conversation, the experts provide a comprehensive reflection on the field and the factors that may shape how clinicians approach care moving forward.