Advances in Primary Biliary Cholangitis: Expert Insights on Emerging Data and Key Treatment Innovations - Episode 2

Segment 2- Key Symptoms of PBC- Fatigue, Pruritus, and Bone Health

Published on: January 26, 2026

Frances Lee, MD, Aparna Goel, MD, A. Sidney Barritt IV, MD, MSCR, Lance L. Stein, MD

Explore the complex relationship between pruritus, fatigue, and bone health in patients with primary biliary cholangitis (PBC).

EP. 1: Segment 1- An Overview of PBC Pathophysiology, Severity, and Burden

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EP. 2: Segment 2- Key Symptoms of PBC- Fatigue, Pruritus, and Bone Health

In this episode, “Key Symptoms of PBC: Fatigue, Pruritus, and Bone Health,” the expert hepatologists explore extrahepatic symptoms associated with this disease.

Led by the moderator, the panelists examine the following critical questions:

What do we know about the underlying causes of these extrahepatic symptoms of primary biliary cholangitis?

Another common complication associated with PBC is bone disease; about 30% of patients with PBC also have osteoporosis. How often do you see bone complications in clinic, and how does it impact a patient’s quality of life?

Throughout the conversation, the experts provide a comprehensive reflection on the field and the factors that may shape how clinicians approach care moving forward.