Advances in Primary Biliary Cholangitis: Expert Insights on Emerging Data and Key Treatment Innovations - Episode 4

Diagnostic Criteria in PBC: What Clinicians are Looking For

Published on: February 2, 2026

Frances Lee, MD, Aparna Goel, MD, A. Sidney Barritt IV, MD, MSCR, Lance L. Stein, MD

Learn how to diagnose Primary Biliary Cholangitis (PBC) through key criteria and the importance of specific autoantibodies in patient evaluation.

EP. 1: An Overview of PBC Pathophysiology, Severity, and Burden

EP. 2: Key Symptoms of PBC- Fatigue, Pruritus, and Bone Health

EP. 3: Assessing Disease Severity and Progression Risk in PBC

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EP. 4: Diagnostic Criteria in PBC: What Clinicians are Looking For

EP. 5: Experts Review the First- and Second-Line Treatment Options for PBC

EP. 6: How Special Populations and Disease Risk Impact Treatment Assessment in PBC

EP. 7: The Efficacy of PPAR Agonists in PBC: Signals of Extrahepatic Improvements

EP. 8: The Safety of PPAR Agonists in PBC: Reviewing Recent Trial Data

This episode, titled “Diagnostic Criteria in PBC: What Clinicians are Looking For” features panelists discussing the key three criteria that clinicians use to inform a primary biliary cholangitis diagnosis.

Led by the moderator, the experts examine the following critical questions:

What specific criteria inform the diagnosis of primary biliary cholangitis?

Can you discuss the complexities of interpreting results from an antimitochondrial antibody (AMA) tests?

When is it necessary to perform a biopsy to confirm a diagnosis of primary biliary cholangitis?

Throughout the conversation, the experts provide a comprehensive reflection on the field and the factors that may shape how clinicians approach care moving forward.

In the next episode, “Experts Review the First- and Second-Line Treatment Options for PBC” panelists will continue their discussion on PBC and highlight the current treatment landscape and when they typically reassess patients for disease improvements.